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Figure 1: (a) Photomicrograph reveals numerous crowded, back-to-back glands infiltrating the surrounding stroma. Lining epithelium shows nuclear enlargement, prominent nucleoli and abundant cytoplasm. Stroma shows tumor composed of spindle to polygonal cells having atypical nuclei and increased mitotic activity. Occasional tumor giant cells are also seen. (b, d) Sarcomatous element was positive for vimentin and negative for pancytokeratin. (c) AMACR-negative prostatic adenocarcinoma

Figure 1: (a) Photomicrograph reveals numerous crowded, back-to-back glands infiltrating the surrounding stroma. Lining epithelium shows nuclear enlargement, prominent nucleoli and abundant cytoplasm. Stroma shows tumor composed of spindle to polygonal cells having atypical nuclei and increased mitotic activity. Occasional tumor giant cells are also seen. (b, d) Sarcomatous element was positive for vimentin and negative for pancytokeratin. (c) AMACR-negative prostatic adenocarcinoma