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Figure 2: The Hypothalamus-Pituitary-Gonadal Axis. Gonadotropin releasing hormone is produced in the hypothalamus which in turn stimulates the anterior pituitary gland to produce luteinizing hormone/follicle stimulating hormone and adrenocorticotropic hormone. LH and FSH travel in the systemic circulation to the testes where they are involved in the production of testosterone and spermatogenesis by stimulation of Leydig and Sertolicells respectively. ACTH on the other hand travels to the adrenal gland where it stimulates the production of corticosteroids. Re-used from Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgen-deprivation therapy on the immune system: Implications for combination therapy of prostate cancer. Front Biosci 2007;12:4957-71 with permission from frontiers in bioscience

Figure 2: The Hypothalamus-Pituitary-Gonadal Axis. Gonadotropin releasing hormone is produced in the hypothalamus which in turn stimulates the anterior pituitary gland to produce luteinizing hormone/follicle stimulating hormone and adrenocorticotropic hormone. LH and FSH travel in the systemic circulation to the testes where they are involved in the production of testosterone and spermatogenesis by stimulation of Leydig and Sertolicells respectively. ACTH on the other hand travels to the adrenal gland where it stimulates the production of corticosteroids. Re-used from Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgen-deprivation therapy on the immune system: Implications for combination therapy of prostate cancer. Front Biosci 2007;12:4957-71 with permission from frontiers in bioscience