Indian J Med Microbiol Close
 

Figure 1: Chromosomal and protein domains of the Vitamin D receptor. The human VDR gene located on chromosome 12q, is composed of nontranslated exons (A-F) and exons 2-9, which encode 6 domains (A-F) of the full-length VDR protein. VDR associates with RXR through the dimerization domains (yellow). The 1α,25(OH)2D3-VDR-RXR complex binds to VDREs through the DNA-binding domain in the regulatory region of target genes. FokI, BsmI, ApaI, TaqI and Tru9I (SNPs) have been identified in VDR

Figure 1: Chromosomal and protein domains of the Vitamin D receptor. The human VDR gene located on chromosome 12q, is composed of nontranslated exons (A-F) and exons 2-9, which encode 6 domains (A-F) of the full-length VDR protein. VDR associates with RXR through the dimerization domains (yellow). The 1α,25(OH)2D3-VDR-RXR complex binds to VDREs through the DNA-binding domain in the regulatory region of target genes. FokI, BsmI, ApaI, TaqI and Tru9I (SNPs) have been identified in VDR