Indian Journal of Urology
LETTER TO EDITOR
Year
: 2022  |  Volume : 38  |  Issue : 4  |  Page : 330-

Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210


Prashant Kumar Sharma, Sridhar Panaiyadiyan, Santosh Kurra, Raman Kumar, Brusabhanu Nayak, Seema Kaushal, Alpana Sharma, Rajeev Kumar, Amlesh Seth, Prabhjot Singh 
 Department of Urology, Biochemistry and Pathology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Prabhjot Singh
Department of Urology, Biochemistry and Pathology, All India Institute of Medical Sciences, New Delhi
India




How to cite this article:
Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, Sharma A, Kumar R, Seth A, Singh P. Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210.Indian J Urol 2022;38:330-330


How to cite this URL:
Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, Sharma A, Kumar R, Seth A, Singh P. Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210. Indian J Urol [serial online] 2022 [cited 2023 Jan 29 ];38:330-330
Available from: https://www.indianjurol.com/text.asp?2022/38/4/330/357733


Full Text



We appreciate the author's interest in our recently published article on penile carcinoma (PeCa).[1] Regarding the query on telomerase activity in the control group, we did not find any difference in the telomerase activity between high-risk human papillomavirus (HPV)-infected and uninfected controls. Our study findings of higher telomerase activity in PeCa cases, which is insignificant with HPV-positivity status signals, telomerase activity is unaffected by HPV infection once the carcinogenesis sets in. However, the telomerase activity in HPV-affected cancers increases with the severity of the disease.[2] This was evident in the present study as the mean telomerase activity increased with the worsening of the tumor grade.

We also agree with the authors that further studies are warranted focussing on epigenetic alterations such as histone modifications, DNA methylation, and nonencoding RNAs after stratifying to different subtypes of PeCa for a better understanding of the role of HPV in PeCa.

Financial support and sponsorship: Nil.

Conflicts of interest: There are no conflicts of interest.

References

1Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210.
2Katzenellenbogen R. Telomerase induction in HPV infection and oncogenesis. Viruses 2017;9:180.