Indian Journal of Urology
ORIGINAL ARTICLE
Year
: 2012  |  Volume : 28  |  Issue : 4  |  Page : 424--426

Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer: The likelihood of initiation and completion


Ahmed Eldefrawy1, Mark S Soloway1, Devendar Katkoori1, Rakesh Singal2, David Pan1, Murugesan Manoharan1 
1 Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA
2 Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA

Correspondence Address:
Murugesan Manoharan
Department of Urology, University of Miami Miller School of Medicine, P.O. Box 016960 (M814), Miami, FL
USA

Introduction: Chemotherapy was shown to improve survival in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The initiation and completion rates for perioperative chemotherapy are variable. Our aim is to compare the likelihood of initiating and completing neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients who underwent of RC for MIBC. Materials and Methods: We performed a retrospective analysis of patients who underwent RC between 1992 and 2011. NAC was advised for patients with clinical stage ≥T2, hydronephrosis, extensive lymphovascular invasion (LVI), or prostatic stromal invasion. Patients with ≥pT3 or lymph node metastases were considered for AC. Results: A total of 363 patients were considered for perioperative chemotherapy. Among the 141 patients who were offered NAC, 125 (88.6%) initiated NAC. A total of 222 were considered for AC, and 151 (68.0%) initiated AC (P < 0.001). In the NAC group, 118 (83.5%) completed planned number of cycles of chemotherapy and 7 (5.6%) did not complete the planned chemotherapy. In the AC group, 79 (35.5%) completed at least four cycles and 72 (47.3%) could not complete the planned cycles (P < 0.001). Conclusions: Patients with MIBC are more likely to initiate and complete NAC than AC.


How to cite this article:
Eldefrawy A, Soloway MS, Katkoori D, Singal R, Pan D, Manoharan M. Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer: The likelihood of initiation and completion.Indian J Urol 2012;28:424-426


How to cite this URL:
Eldefrawy A, Soloway MS, Katkoori D, Singal R, Pan D, Manoharan M. Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer: The likelihood of initiation and completion. Indian J Urol [serial online] 2012 [cited 2022 Sep 30 ];28:424-426
Available from: https://www.indianjurol.com/article.asp?issn=0970-1591;year=2012;volume=28;issue=4;spage=424;epage=426;aulast=Eldefrawy;type=0