Year : 2009 | Volume
: 25 | Issue : 2 | Page : 207--210
Impact of age and gender on the clinicopathological characteristics of bladder cancer
Parag Gupta, Manoj Jain, Rakesh Kapoor, K Muruganandham, Aneesh Srivastava, Anil Mandhani
Department of Urology, Renal Transplantation, SGPGIMS, Lucknow, India
Purpose: To determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India.
Materials and Methods: From January 2001 to June 2008, records of patients with bladder cancer were evaluated for age and gender at presentation, clinical symptoms, cystoscopic finding, history of smoking, and histopathological characteristics. A total of 561 patients were identified from the computer-based hospital information system and the case files of patients.
Results: A total of 97% of the patients presented with painless hematuria. The mean age was 60.2 ± 4.4 years old (range: 18-90 years old) and the male to female ratio was 8.6:1. Transitional cell carcinoma (TCC) was the most common histological variety, which was present in 97.71% (470 of 481) of the patients. A total of 26% of the patients had muscle invasive disease at the time of presentation. However, 34.5% (166 of 481) of the patients did not show any evidence of detrusor muscle in their biopsy specimen. In patients with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1. Overall, 44.7% (215 of 481) of the patients had low-grade disease. Among patients younger than 60 years old, low-grade (51.0% vs. 38.1%; P = 0.006) and low-stage (77.1% vs. 70.8%; P = 0.119) disease were more prevalent than in patients older than 60 years old. The incidence of smoking was much higher among males compared with females (74% vs. 22%).
Conclusion: TCC is the predominant cancer, with significant male preponderance among Indian patients. Younger-aged patients have low-grade disease. Hematuria is the most common presentation and greater awareness is needed not to overlook bladder cancer.
Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow-226 014
|How to cite this article:|
Gupta P, Jain M, Kapoor R, Muruganandham K, Srivastava A, Mandhani A. Impact of age and gender on the clinicopathological characteristics of bladder cancer.Indian J Urol 2009;25:207-210
|How to cite this URL:|
Gupta P, Jain M, Kapoor R, Muruganandham K, Srivastava A, Mandhani A. Impact of age and gender on the clinicopathological characteristics of bladder cancer. Indian J Urol [serial online] 2009 [cited 2021 Apr 12 ];25:207-210
Available from: https://www.indianjurol.com/article.asp?issn=0970-1591;year=2009;volume=25;issue=2;spage=207;epage=210;aulast=Gupta;type=0