Indian Journal of Urology
: 2004  |  Volume : 20  |  Issue : 2  |  Page : 53--54

Squamous cell carcinoma of prostate - a case report

L Sudhakar, C Anand, G Sivasankar, N Muthulatha, MG Rajamanickam 
 Chennai, India

Correspondence Address:
L Sudhakar
C/o.Dr.M.G.Rajamanickam, No.7, Anandan Street, T.Nagar, Chennai - 600 017

How to cite this article:
Sudhakar L, Anand C, Sivasankar G, Muthulatha N, Rajamanickam M G. Squamous cell carcinoma of prostate - a case report.Indian J Urol 2004;20:53-54

How to cite this URL:
Sudhakar L, Anand C, Sivasankar G, Muthulatha N, Rajamanickam M G. Squamous cell carcinoma of prostate - a case report. Indian J Urol [serial online] 2004 [cited 2022 May 20 ];20:53-54
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 Case Report

A 29 year old male presented with dysuria, constipation and loss of weight of 6 months duration. The patient was anaemic and emaciated. Examination of abdomen and genitalia was normal. Rectal examination revealed a large, hard, tender irregular prostatic mass almost occluding the rectum. On evaluation haemoglobin was 8.0gms% and renal parameters were normal. Serum PSA was 4ng/mL. X­ray KUB and X-ray Chest were normal.

Ultrasonogram showed a 6.5 x 6.4 x 6.4 cm hypoechoeic prostate with internal echoes. Contrast CT scan revealed a mixed dense mass in the region of prostate displacing the bladder and rectum and heterogenous enhancement with contrast without any nodal enlargement [Figure 1]. Transrectal biopsy showed features of well differentiated squamous cell carcinoma of prostate [Figure 2].

Cystoscopy showed a bulge in the posterior wall of the bladder. Further workup for any occult primary was normal. A final diagnosis of primary squamous cell carcinoma of prostate with T4N0 M0 was made. Eventhough the ideal treatment is surgery, due to the local invasion and poor general condition primary radiotherapy was given.


Primary squamous cell carcinoma of prostate is rare accounting for 0.5% of all prostate carcinomas, and it is difficult to differentiate from disease arising from bladder and urethra [1] . It occurs denovo or more commonly as squamous differentiation from adenocarcinoma after hormonal or radiotherapy. Keratinisation and intercellular bridging are present in the histology with a lack of glandular differentiation [2] . Serum PSA levels are not elevated and patients develop osteolytic metastasis [3] . It is more aggressive than adenocarcinoma and refractory to androgen blockade, hence a poor survival rate.


1Mott LJ, Squamous cell carcinoma of prostate; Report of two cases and review of the Literature. J Urol. 1979; 121 : 833.
2Vincent T Devita, Samuel Hellman, Steven A. Rosenberg : Cancer Principles and Practice of oncology, 6th Edition. Philadelphia; Lippincott Williams& Wilkins Publishers. 2001 :1422.
3Little NA, Wiener JS, Walther PJ, et al : Squamous cell carcinoma of the prostate - 2 cases of a rare malignancy and reviewofthe literature. J Urol. 1993; 149:137- 139.