Indian Journal of Urology
ORIGINAL ARTICLE
Year
: 2002  |  Volume : 19  |  Issue : 1  |  Page : 63--67

Renal functional reserve in live related kidney donors


Monish Aron, SN Mehta, SC Tiwari, MG Karmarkar, Sandeep Guleria, Rekha Sharma 
 Departments of Urology, Surgical Disciplines, Nephrology & Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Sandeep Guleria
Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi - 110 029
India

Objectives: To determine the renal functional reserve in live related donors and compare it with that of normal controls. Patients and Methods: The study group consisted of 12 subjects who underwent donor nephrectomy at our cen­tre, more than 6 months prior to this study. The control group consisted of 12 healthy, age and sex-matched vol­unteers who had no previous history of renal disease. The test for renal, functional reserve consisted of a 2 hour base­line creatinine clearance followed by ingestion of 1.2 grains of protein per kg body weight, in the form of cooked red meat, over one hour: A subsequent 2-hour creatinine clearance starting one hour after the completion of pro­tein load was done. Urine collections were meticulously supervised and serum creatinine levels were obtained at the midpoint of each urine collection. Results: The rise in serum creatinine and creatinine clear­ance after protein loading was statistically significant in both donors and controls. The test used for estimation for renal, functional reserve was the percent change in creati­nine clearance after an acute protein load. This was 26.9 % in the donor population and 29.6 % in the controls. The difference between the 2 groups, therefore, was not statisti­cally significant. Conclusions: The preservation of renal functional re­serve implies that kidney donors are at no significant dis­advantage compared to normal healthy people, by virtue of their kidney donation.


How to cite this article:
Aron M, Mehta S N, Tiwari S C, Karmarkar M G, Guleria S, Sharma R. Renal functional reserve in live related kidney donors.Indian J Urol 2002;19:63-67


How to cite this URL:
Aron M, Mehta S N, Tiwari S C, Karmarkar M G, Guleria S, Sharma R. Renal functional reserve in live related kidney donors. Indian J Urol [serial online] 2002 [cited 2021 Dec 6 ];19:63-67
Available from: https://www.indianjurol.com/article.asp?issn=0970-1591;year=2002;volume=19;issue=1;spage=63;epage=67;aulast=Aron;type=0