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Year : 2022  |  Volume : 38  |  Issue : 4  |  Page : 323-324
 

Triple therapy for metastatic castration sensitive prostate cancer: PEACE-1 trial


Department of Urology, AIIMS, Bhubaneswar, Odisha, India

Date of Submission14-Jun-2022
Date of Decision09-Aug-2022
Date of Acceptance05-Sep-2022
Date of Web Publication1-Oct-2022

Correspondence Address:
Kirti Singh
Department of Urology, AIIMS, Bhubaneswar, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/iju.iju_200_22

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How to cite this article:
Singh K. Triple therapy for metastatic castration sensitive prostate cancer: PEACE-1 trial. Indian J Urol 2022;38:323-4

How to cite this URL:
Singh K. Triple therapy for metastatic castration sensitive prostate cancer: PEACE-1 trial. Indian J Urol [serial online] 2022 [cited 2022 Dec 1];38:323-4. Available from: https://www.indianjurol.com/text.asp?2022/38/4/323/357722





   Summary Top


PEACE-1[1] was a multicenter, open-label, phase-3 randomized controlled trial (RCT) undertaken by the PEACE European consortium. It enrolled 1173 men from seven countries with synchronous (de novo) metastatic hormone sensitive prostate cancer (mCSPC), who were randomly assigned in a 1:1:1:1 ratio to receive SOC (standard of care, i.e., ADT with docetaxel), SOC + RT, SOC + abiraterone (AP), or SOC + RT + AP (i.e., abiraterone + prednisolone). A randomized 2 × 2 factorial design was used to compare radiotherapy (RT) to primary tumor against AP + RT. The co-primary endpoints were overall survival (OS) and radiographic progression-free survival (RPFS). Adjusted cox regression modeling revealed no interaction between AP and RT; this allowed the pooled analysis of AP efficacy.

Notable findings of PEACE-1 include the following - Trial showed an advantage of two and half years (2 years with SOC vs. 4.5 years with the addition of AP) for RPFS. OS was improved with a 25% reduction in risk of death, even when 84% of mCSPC men in the control group receive at least one life-prolonging treatment. The incidence of grade 3–5 neutropenia and febrile neutropenia was comparable between the two groups, at 10% versus 9% and 5% versus 5%, respectively, but the rates of hypertension and transaminase elevations were higher, at 22% versus 13% and 6% versus 1%, respectively.

This RCT concluded that combining SOC with AP improved both co-primary endpoints of OS (hazard ratio [HR] = 0.82) only in high-volume disease and RPFS (HR = 0.54).


   Comments Top


The focus of recent advances in carcinoma prostate has now shifted from the management of castrate resistant to castrate-sensitive patients. The ideal combination of various agents in setting of mCSPC has still not been assessed. for high-volume mCSPC, the addition of AP (+prednisolone) to SOC makes sense. Till date, PEACE-1 is the only phase 3 trial to show that a triple systemic therapy, combining ADT, docetaxel, and AP improves both OS and RPFS in patients with de novo mCSPC without significantly increasing toxicity.

The current SOC is ADT + Docetaxel.[2] It is based on the results of a systematic review and meta-analysis by Sathianathen et al., in 2018[3] which included STAMPEDE, GETUG, and CHAARTED trials. STOPCAP systemic review and meta-analysis[4] showed that AP has the highest probability of success. Based on the above two meta-analyses, the addition of AP to ADT + Doctaxel is a good proposition as done in PEACE-1.

PEACE-1 trial showed survival advantage as AP improves OS, while docetaxel (D) retains some efficacy even after AP failure also concomitant administration (AP + D) did not lead to an increase in side effects or hematological toxicity.

A similar ongoing phase 3 trial ARASENS[5] is assessing efficacy of darolutamide with ADT and docetaxel.

PEACE-1 had a complicated design that was made even more complicated by its modifications. The trial is still ongoing and the results of secondary endpoints are not reported yet, and the efficacy of RT remains unanalyzed. Formal analysis of quality of life data is still pending which will tell the impact of toxicity on participants and we eagerly wait for the final results of this trial as it will be helpful to obtain a piece of concrete evidence for hormonal therapy in mCSPC and further enhance the level of evidence what is present.

The crucial questions that remained to be answered are - If there is a subset of individuals who do not require such an aggressive treatment regimen and if de-escalation after a good response with the prescribed treatment regimen could have any bearing on the survival outcomes. These will necessitate well-designed clinical trials in future.

This trial points toward the need to escalate treatment in patients with high-volume mCSPC. AP is available commonly even in developing countries. The addition of AP to SOC can be vastly beneficial, especially in developing countries like ours where the majority of the patients present with high-volume disease. However, the application of this regimen in various subsets such as metachronous metastasis or long-term benefit in high- versus low-volume disease still remains to be seen. Furthermore, many a times, SOC to start with is ADT + AP. Hence, based on the study design, this trial would not be able to answer the triplet therapy by adding docetaxel to ADT + AP. Biomarkers which can identify patients at the highest risk of disease progression to mCRPC may further help in recommending triplet therapy in mCSPC patients.

Future superiority trials may add evidence regarding the true value of triplet therapy. With longer follow-up data, triplet therapy may soon become the treatment of choice for mCSPC.

Financial support and sponsorship: Nil.

Conflicts of interest: There are no conflicts of interest.



 
   References Top

1.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, et al. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): A multicentre, open-label, randomised, phase 3 study with a 2×2 factorial design. Lancet 2022;399:1695-707.  Back to cited text no. 1
    
2.
EAU Guidelines 2022: Prostate Cancer. Uroweb. Available from: https://uroweb.org/guidelines/prostate-cancer. [Last accessed on 2022 Jun 22].  Back to cited text no. 2
    
3.
Sathianathen NJ, Philippou YA, Kuntz GM, Konety BR, Gupta S, Lamb AD, et al. Taxane-based chemohormonal therapy for metastatic hormone-sensitive prostate cancer. Cochrane Database Syst Rev 2018;10:CD012816.  Back to cited text no. 3
    
4.
Vale CL, Fisher DJ, White IR, Carpenter JR, Burdett S, Clarke NW, et al. What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis. Ann Oncol 2018;29:1249-57.  Back to cited text no. 4
    
5.
Smith MR, Hussain M, Saad F, Fizazi K, Sternberg CN, Crawford ED, et al. Darolutamide and survival in metastatic, hormone-sensitive prostate cancer. N Engl J Med 2022;386:1132-42.  Back to cited text no. 5
    




 

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