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Year : 2013  |  Volume : 29  |  Issue : 1  |  Page : 2-11

The use of botulinum toxin for the treatment of overactive bladder syndrome

Departments of Urology and Obstetrics and Gynecology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA

Correspondence Address:
Bogdan Orasanu
Department of Urology, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.109975

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Over the last 50 years, botulinum toxin has been transformed from a cause of life-threatening disease to an effective medical therapy. It has been used in a variety of specialties for different indications, significantly improving patient quality of life. A recent growing body of evidence suggests that intra-detrusor injection of botulinum toxin may have beneficial effects in patients with medication refractory detrusor overactivity and may offer a new minimally invasive alternative to patients with severe overactive bladder symptoms. To review current data regarding the effects of botulinum toxin in patients with overactive bladder, a MEDLINE® /PubMed® literature search was carried out. The mechanism of action, clinical usage, adverse effects, and treatment efficacy were reviewed and the results are presented in this paper.

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