Indian Journal of Urology Users online:2030  
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size

  Table of Contents 
Year : 2012  |  Volume : 28  |  Issue : 4  |  Page : 430-433

Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature

1 Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication10-Jan-2013

Correspondence Address:
Kirti Gupta
Associate Professor, Department of Histopathology, PGIMER, Chandigarh-160012
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.105760

Rights and Permissions


The sarcomatous differentiation occurring in spermatocytic seminoma (SS) renders an aggressive behavior with metastatic potential to this relatively indolent neoplasm. Correct identification of this sarcomatous component is essential as further management differs. Herein, we report a case of young male with SS with rapid increase in size of the tumor. Histopathology revealed a rhabdomyosarcomatous component infiltrating the rete-testis and epididymis along with a well-circumscribed SS.

Keywords: Rhabdomyosarcomatous differentiation, spermatocytic seminoma, testis

How to cite this article:
Narang V, Gupta K, Gupta A, Kumar S. Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. Indian J Urol 2012;28:430-3

How to cite this URL:
Narang V, Gupta K, Gupta A, Kumar S. Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. Indian J Urol [serial online] 2012 [cited 2022 Oct 1];28:430-3. Available from:

   Introduction Top

Spermatocytic seminoma (SS) is an uncommon testicular germ cell neoplasm with distinct histopathological features. It usually occurs in older men with mean age of 53.6 years (range 19-72 years). [1] It bears an excellent prognosis but tends to behave aggressively and renders a poor prognosis if associated with sarcomatous transformation. Patients with sarcomatous transformation at the time of presentation already have metastatic disease and this is almost fatal. [2],[3] The sarcoma component may present as rhabdomyosarcoma, angiosarcoma, leiomyosarcoma, myxoid liposarcoma or undifferentiated sarcoma. [4] The identification and diagnosis of the sarcomatous component is pertinent for planning further management. We describe a case of a young man with SS developing rhabdomyosarcomatous transformation.

Clinical findings

A 38-year-old man presented with long standing history of swelling in right hemiscrotum. He underwent right testicular biopsy in a local medical college, which was diagnosed as seminoma. The patient was referred to our institute for further evaluation. On examination, he gave a history of sudden increase in size of the mass. There was a right testicular mass measuring 10 × 10 cm, with scrotal violation and left testis was normal. His general physical examination was normal. The serum tumor markers i.e., alfa-fetoprotein (AFP) and beta HCG were within normal. Hematological and biochemical parameters were normal. Chest X-ray, CECT abdomen and pelvis were normal. He underwent right high inguinal orchidectomy and hemiscrotectomy in view of scrotal violation. Retroperitoneal lymph node dissection (RPLND) was not performed as radiologically there was no lymphadenopathy. In addition to local and abdominal radiotherapy, chemotherapy (with vincristine, actinomycin D and cyclophosphamide) was given. Two months postoperatively, the patient is on follow-up and doing well.

Pathological Findings

The right high inguinal orchidectomy specimen measured 7 × 6 × 4 cm with attached vas deferens and scrotal skin. The testicular shape was maintained. On cut surface, a tumor measuring 6 × 6 cm was seen replacing the entire testicular parenchyma. The tumor was yellow, soft, and homogenous with a lobulated appearance. Most of the nodules were gelatinous with some appearing darker in color and firm in consistency than the rest [Figure 1]a. Microscopically, the spermatocytic component consisted of polymorphic cell population with large cells having characteristic 'spermine' chromatin; intermediate-sized cells and small lymphocyte-like cells [Figure 1]b. The mitotic activity was very brisk [Figure 1]c. At places, the cells were clustered around the vessels. The cells were immunopositive with c-kit (CD117) [Figure 1]d but were negative with PLAP (placental-like alkaline phosphatase).The other component of the tumor consisted of fascicles of spindle shaped cells with fusiform nuclei [Figure 2]a and b. The sarcomatous component was seen destroying the epididymis and rete testis. Admixed with both the components were many multinucleated and bizarre tumor giant cells with hyperchromatic nuclei. Few strap cells and globoid cells were identified within the fascicles of spindle cells [Figure 2]c. No morphologic transition between the two cell types was apparent. No areas of intratubular germ cell neoplasia (ITGCN) or other associated germ cell components were identified. The tunica albuginea was, however, not infiltrated by the tumor. No lymphovascular emboli were seen. Immunohistochemically, the spermatcocytic component was negative for placental alkaline phosphatase (PLAP), CD30, smooth muscle-actin, and the spindle cells were strongly positive for desmin [Figure 2]d and weakly for myoglobin.
Figure 1: (a) Lobulated, soft and homegenous cut surface of the tumor with few nodules appearing form and dark in color (arrow). (b) Spermatocytic seminoma with three types of cells (small, intermediate and large) with fine fibrovascular septa traversing between them (H&E ×400). (c) Brisk mitotic activity within the seminomatous component (H&E ×400). (d) Spermatocytic seminoma cells show cytoplasmic positivity with c-kit (immunoperoxidase ×400)

Click here to view
Figure 2: (a) Long fascicles of spindle cells (H&E ×200). (b) Sarcomatous component in close apposition with the seminomatous component (HXE ×200). (c) Desmin immunostain highlighting the strap cells (immunoperoxidase ×400). (d) Sarcomatous component immunopositive with desmin (immunoperoxidase ×400)

Click here to view

   Discussion Top

SS is a relatively rare, well-defined pathological entity first described by Masson [5] comprising 3-7% of all seminomas. [3] It is an indolent neoplasm with long duration of symptoms, early stage at presentation, absence of metastasis and bears an excellent prognosis. [6] However, dedifferentiation or transformation to a sarcoma which occurs in approximately 6% of cases renders a poor prognosis with a metastatic potential. [7] Literature review cites small series [3] and a few case reports [8],[9],[10] of occurrence of sarcomatous differentiation in SS. The occurrence of rhabdomyosarcomatous differentiation is rare and has been described in the literature in eight previous case reports [Table 1]. [6],[8],[9],[11] In the present case, the sarcomatous transformation occurred at a much early age of 38 years compared to the previous cases. The sudden increase in size should always suggest emergence of a sarcomatous component. Light microscopic findings are usually diagnostic after one appreciates the two components distinctly. However, it is important to be aware of misinterpreting the focal areas of atypical stromal overgrowth within conventional germ cell tumor. True sarcomatous component can be distinguished by its expansile growth pattern, infiltration into the surrounding elements and characteristic morphology of the distinct sarcomatous components. [4] Immunohistochemistry helps in highlighting and further categorizing the sarcomatous element.
Table 1: Review of reported cases of spermatocytic seminoma with rhabdomyosarcomatous differentiation

Click here to view

The seminomatous component was well circumscribed but the rhabdomyosarcomatous component was seen infiltrating and destroying the rete testis and epididymis. Identification of epithelial structures of rete testis is important as these may be mistaken for epithelial component of a mixed nonseminomatous germ cell tumor.

The origin of the sarcomatous elements of these tumors and the relation to the spermatocytic component is uncertain. Few have implied [12],[13] this sarcoma component to be a teratomatous element of a mixed germ cell tumor as the occasional occurrence of sarcomatous elements (chiefly rhabdomyosarcoma, angiosarcoma, and leiomyosarcoma) in gonadal and extragonadal germ cell tumors is well known. The serum elevation of alpha-fetoprotein and beta-HCG favors this hypothesis. The serum tumor markers were not elevated in the present case. However, other authors view the sarcomatous component as an 'anaplastic transformation' or 'dedifferentiation' occurring within the well-differentiated neoplasm which seems most plausible. [3] The development of this tumor, first with slow enlargement of the testis followed by rapid increase in size tends to favor the explanation of sarcomatous differentiation occurring in SS.

The treatment of choice in SS is orchidectomy, followed by surveillance to detect tumor in the contralateral testis. However, in the presence of sarcomatous differentiation, adjuvant chemotherapy or radiotherapy is beneficial. As the risk of metastases if remarkably increased with this transformation, a close follow-up is essential; however, prognosis is dismal despite aggressive multimodality approach. [3],[6]

In conclusion, this case describes the rare sarcomatous differentiation occurring in SS heralded by a rapid increase in size, which portends a poor prognosis to this indolent neoplasm. Accurate and timely diagnosis is pertinent for planning further management of the patient.

   References Top

1.Talerman A. Spermatocytic seminoma: A clinicopathological study of 22 cases. Cancer 1980; 45: 2169-76.  Back to cited text no. 1
2.Ebele JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Tumors of testis and paratesticular region. IARC publishers; 2004. p. 233-6.  Back to cited text no. 2
3.True LD, Otis CN, Delprado W, Scully RE, Rosai J. Spermatocytic seminoma of the testis with sarcomatous transformation. Am J Surg Pathol 1988;12:75-82.  Back to cited text no. 3
4.Malagon HD, Valdez AMC, Moran CA, Suster S. Germ cell tumors with sarcomatous component. A clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol 2007;31:1356-61.  Back to cited text no. 4
5.Masson P. Etude sur seminome. Revue Canadienne se Biologie 1946; 5:361-87.  Back to cited text no. 5
6.Chelly I, Mekni A, Gargouri MM, Bellil K, Zitouna M, Horchani A, et al. Spermatocytic seminoma with rhabdomyosarcomatous contigent. Prog Urol 2006;16:218-20.  Back to cited text no. 6
7.Chung PW, Bayley AJ, Sweet J, Jewett MA, Tew-George B, Gospodarowicz MK, et al. Spermatocytic seminoma: A review. Eur Urol 2004;45:495-8.  Back to cited text no. 7
8.Matoska J, Talerman A. Spermatocytic seminoma associated with rhabdomyosarcoma. Am J Clin Pathol 1990;94:89-95.  Back to cited text no. 8
9.Menon S, Karpate A, Desai S. Spermatocytic seminoma with rhabdomyosarcomatous differentiation. A case report and a review of literature. J Cancer Res Ther 2009;5:213-5.  Back to cited text no. 9
10.Trivedi P, Pasricha S, Gupta A. Spermatocytic seminoma associated with undifferentiated sarcoma: A rare case report. Indian J Pathol Microbiol 2011;54:138-40.  Back to cited text no. 10
[PUBMED]  Medknow Journal  
11.Robinson A, Bainbridge T, Kollmannsberger C. A spermatocytic seminoma with rhabdomyosarcoma transformation and extensive metastases. Am J Clin Oncol 2007;30:440-1.  Back to cited text no. 11
12.Mostofi FK, Prince EB. Tumors of the male genital system. Atlas of tumor pathology, scond series, Fascicle 8. Washington DC: Armed Forces Institute of Pathology, 1973. p. 70-1.  Back to cited text no. 12
13.Ulbright TM, Clark SA, Einhorn LH. Angiosarcoma associated with germ cell tumors. Hum Pathol 1985;16:268-72.  Back to cited text no. 13


  [Figure 1], [Figure 2]

  [Table 1]

This article has been cited by
1 An Update on Diagnostic Tissue-Based Biomarkers in Testicular Tumors
Stephanie E. Siegmund, Rohit Mehra, Andres M. Acosta
Human Pathology. 2022;
[Pubmed] | [DOI]
2 Sarcomatoid Spermatocytic Tumour: Report of a Rare Case and Literature Review
André Fontes Dias, Eugénia Dvindenko, Filipa Santos, Rafael Cabrera
International Journal of Surgical Pathology. 2022; : 1066896922
[Pubmed] | [DOI]
3 Spermatocytic seminoma of testis associated with undifferentiated sarcoma revealed in metastatic disease: A review and case report analysis
Mehdi Chennoufi, Ibrahim Boukhannous, Mohamed Mokhtari, Anouar El Moudane, Ali Barki
Urology Case Reports. 2021; 38: 101732
[Pubmed] | [DOI]
4 Transformación maligna secundaria de teratomas testiculares: serie de casos y revisión de la literatura
L. García-Labastida,G.S. Gómez-Macías,J.P. Flores-Gutiérrez,M. Ponce-Camacho,J. Ancer-Rodríguez,O. Barboza-Quintana,R. Garza-Guajardo
Actas Urológicas Españolas. 2014;
[Pubmed] | [DOI]
5 Secondary malignant transformation of testicular teratomas: Case series and literature review
L. García-Labastida,G.S. Gómez-Macías,J.P. Flores-Gutiérrez,M. Ponce-Camacho,J. Ancer-Rodríguez,O. Barboza-Quintana,R. Garza-Guajardo
Actas Urológicas Españolas (English Edition). 2014; 38(9): 622
[Pubmed] | [DOI]
6 The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle
Farhana Sharmeen,Michael H. Rosenthal,Stephanie A.H. Howard
Clinical Imaging. 2013;
[Pubmed] | [DOI]
7 A rare case of bilateral sequential spermatocytic seminoma
Ning Xu,Fubiao Li,Runhui Tian,Mingming Shao,Lingyun Liu,Kaimin Guo
World Journal of Surgical Oncology. 2013; 11(1): 175
[Pubmed] | [DOI]


Print this article  Email this article


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (1,710 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded85    
    Comments [Add]    
    Cited by others 7    

Recommend this journal