Indian Journal of Urology Users online:625  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
  Table of Contents 
CASE REPORT
Year : 2011  |  Volume : 27  |  Issue : 1  |  Page : 135-136
 

Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure


Smt. G. R. Doshi and Smt. K. M. Mehta Institute of Kidney Disease and Research Centre and Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, India

Date of Web Publication29-Mar-2011

Correspondence Address:
Pranjal R Modi
Department of Urology and Transplantation Surgery, Smt G. R Doshi and Smt. K. M. Mehta Institute of Kidney Disease and Research Centre and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad - 380 016
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.78421

Rights and Permissions

 
   Abstract 

Breast carcinoma is the most common nondermatologic cancer diagnosis in women. Common metastatic sites include lymph nodes, lung, liver, and bone. Breast carcinoma metastatic to the bladder has been reported only sporadically. Most patients were symptomatic breast cancer with evidence of disseminated disease at the time of diagnosis. Metastasis usually occurred many years after diagnosis, and the prognosis was poor. We report a case of breast caricinoma metastasizing to the urinary bladder and retroperitoneum, which presented initially with acute renal failure. Patient was treated with bilateral per cuteneous nephrostomies and chemotherapy. Starting from this clinical case we review the available literature on this issue. Patients with breast cancer presenting with urinary symptoms should be examined for possible bladder metastasis.


Keywords: Acute renal failure, breast cancer, metastasis, reteroperitoneum, urinary bladder


How to cite this article:
Shah KG, Modi PR, Rizvi J. Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure. Indian J Urol 2011;27:135-6

How to cite this URL:
Shah KG, Modi PR, Rizvi J. Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure. Indian J Urol [serial online] 2011 [cited 2020 Oct 25];27:135-6. Available from: https://www.indianjurol.com/text.asp?2011/27/1/135/78421



   Introduction Top


Urinary bladder metastasis from solid tumors is rare and represents 2% of all bladder neoplasms. [1] Direct extension from the cervix, prostate and colon is not unusual but metastasis from a distant organ is extremely rare. Breast cancer represents as a primary site in about 2.5% cases of all metastatic bladder cancer. [1] Breast cancer commonly metastasizes to the lung, bone, liver, lymph nodes and skin; less frequently it involves the brain, adrenal glands, ovary, spleen, pancreas, kidney, thyroid and heart. [2] There are reports on unusual sites of breast cancer metastases; the urinary bladder and retroperitoneum is considered one of these unusual sites.


   Case Report Top


A 45-year-old premenopausal female patient presented with two months history of recurrent high-grade fever with chills, bilateral pedal edema and oliguria.

On examination bilateral pitting pedal edema was present. Blood investigation revealed serum creatinine of 8.76 mg% and total count was 19,000/cumm. Ultrasonography (USG) showed bilateral hydronephrosis and upper hydroureter. Patient was initially treated with bilateral Double J (DJ )stenting elsewhere. But due to persistent urinary tract infection and renal failure we removed DJ stents and bilateral nephrostomies were kept. Patient's nadir serum creatinine was 1.65 mg%.

Contrast enhanced computerized tomography (CECT ) was suggestive of irregular circumferential moderately enhancing thickening of urinary bladder with hypodense mass lesion in the retroperitoneum with bilateral hydroureteronephrosis [Figure 1]. Cystoscopy showed thick irregular bladder wall with no definitive mass lesion, so random bladder wall biopsies were taken. Biopsy was suggestive of undifferentiated adenocarcinoma [Figure 2].
Figure 1: Contrast enhanced computerized tomography suggestive of irregular circumferential moderately enhancing thickening of urinary bladder

Click here to view
Figure 2: Histopathological examination of bladder biopsy (H and E, x 100) shows metastatic undifferentiated adenocarcinoma, arrow shows tumor cells

Click here to view
Immunohistochemistry was positive for cytokeratin, CK 7 and ER and negative for CK 20 and PR.

Subsequently, during a search for primary site of bladder metastasis, we found patient having right breast mass. True-cut biopsy from right breast mass was suggestive of invasive lobular carcinoma of breast (Nuclear Grade II).

Patient underwent chemotherapy in form of paclitexol and carboplatin. After two cycles of chemotherapy patient started passing urine per urethra and nephrostomy output decreased. So we clamped both the tubes for 48 h and removed both the nephrostomies. After nephrostomy removal patient's serum creatinine remained static at 1.6 mg% and USG showed no hydronephrosis. Patient died after six months due to metastatic disease.


   Discussion Top


Metastases to urinary bladder are rare, accounting for less than 2% of all bladder tumors, these are mostly found in advanced stages with peritoneal dissemination. [1] Information pertaining to bladder metastases is derived largely from autopsy studies, and known primary sites of origin in descending frequency are gastric cancer, malignant melanoma, breast and lung. [1] Potential mechanisms contributing to the appearance of secondary bladder tumors could be due to minute viable tumor emboli that pass through the pulmonary circulation without establishing a lung metastasis and subsequently reach the urinary bladder by hematogenous transport. Other possible routes are extension from retroperitoneal involvement or dissemination through the lymphatic or arterial circulation. [2]

The relative infrequency of primary adenocarcinoma of the bladder causes the dilemma whether bladder adenocarcinoma represents a primary or secondary process. [1] Mostofi et al, have proposed several guidelines for such differentiation. [3] If the adjacent mucosa contains polypoid formation, Brunn's nests, or glandular or mucous metaplasia, a primary bladder lesion is likely. Immunochemistry staining for various markers is routinely used in diagnosis of undifferentiated tumor. Cytokeratin, CK-7, CK-18, CK-19, CK-20 are useful screening markers for the recognition of epithelial differentiation. Other specific markers that are commonly used are ER/ PR for endometrial and breast carcinoma, CA 19-9 for pancreatobiliary malignancy, prostate specific antigen (PSA) for prostate, thyroglobulin for thyroid, uroplakin III for urothelium, and HepPar I for hepatocellular. [4]

In a retrospective study Bates and Baithun found 282 secondary urinary bladder metastases in a series of 6289 bladder tumors (about 4.5% of all bladder tumors detected). Seven cases of primary breast cancer were found; bladder metastases were detected post-mortem in six of these seven cases and all of them had metastasized widely. [1]

Treatment of metastatic breast cancer is chemotherapy and hormonal therapy. Postobstructive renal failure in breast cancer patients can be treated easily by endoureteral catheterization or percutaneous nephrostomy which allows rapid normalization of renal function in most cases and further administration of effective systemic chemotherapy.

Survival after the onset of distant metastases is relatively short, Poulakis et al. in 2001 reported a patient with breast cancer and urinary bladder involvement still alive at five years from diagnosis. [5] Hence, appropriate treatment and follow-up may improve the prognosis of patients with bladder metastases.

 
   References Top

1.Bates AW, Baithun SI. Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: clinicopathological and histological features of 282 cases. Histopathology 2000;36:32-40.  Back to cited text no. 1
    
2.Pontes JE, Oldford JR. Metastatic breast carcinoma to the bladder. J Urol 1970;104:839-42.  Back to cited text no. 2
    
3.Mostofi FK, Thompson RV, Dean AL Jr. Mucous adenocarcinoma of the urinary bladder. Cancer 1955;8:741-58.  Back to cited text no. 3
    
4.Bahrami A, Truong LD, Ro JY. Undifferentiated tumor: true identity by immunohistochemistry. Arch Pathol Lab Med 2008;132:326-48.  Back to cited text no. 4
    
5.Poulakis V, Witzsch U, De Vries R, Becht E. Metastatic breast carcinoma to the bladder: 5- year followup. J Urol 2001;165:905.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2]

This article has been cited by
1 Asymptomatic Bladder Metastasis from Breast Cancer
Luigi Cormio,Francesca Sanguedolce,Giuseppe Di Fino,Paolo Massenio,Giuseppe Liuzzi,Nicola Ruocco,Pantaleo Bufo,Giuseppe Carrieri
Case Reports in Urology. 2014; 2014: 1
[Pubmed] | [DOI]
2 A Case of Recurrent Breast Cancer with Solitary Metastasis to the Urinary Bladder
Carsten Nieder,Adam Pawinski
Case Reports in Oncological Medicine. 2014; 2014: 1
[Pubmed] | [DOI]
3 Kidney metastasis of invasive ductal breast carcinoma mimicking renal cell carcinoma
Akin, Y. and Basara, I.
Saudi Medical Journal. 2012; 33(12): 1346-1349
[Pubmed]



 

Top
Print this article  Email this article
 

    

 
   Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (803 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Introduction
    Case Report
    Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed4257    
    Printed102    
    Emailed2    
    PDF Downloaded49    
    Comments [Add]    
    Cited by others 3    

Recommend this journal

HEALTHWARE INDIA