| CASE REPORT |
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| Year : 2009 | Volume
: 25
| Issue : 1 | Page : 129-131 |
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Epstein-Barr virus positive B-cell lymphoproliferative disorder/polymorphous B-cell lymphoma of the urinary bladder: A case report with review of literature
Sandhya Sundaram1, Kai Zhang2
1 Sri Ramachandra University, Porur, Chennai India & Fellow, Weis Center for Research, USA
2 Geisinger Medical laboratory, Danville, Pennsylvania, USA
Correspondence Address:
Sandhya Sundaram
Department of Pathology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai -116, India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-1591.45552
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We report an unusual case of a localized Epstein-Barr virus (EBV)-positive B cell lymphoproliferative disorder (LPD)/polymorphous B cell lymphoma of the urinary bladder in a 67 years old female patient. She had no known predisposing immunodeficiencies and presented with recent onset of hematuria. The CT and cystoscopic examination revealed a localized 2.5 cm polypoid or plaque-like mucosal mass on the right posterior and lateral wall of the bladder. The biopsy sample showed a diffuse and densely polymorphous atypical lymphoid infiltrate admixed with numerous small lymphocytes, histiocytes and occasional plasma cells and neutrophils. The large atypical cells were CD20+, CD79a+, CD30+, CD43+ and they were strongly positive for EBV by in situ hybridization using anti-EBER-1 probe. Polymerase chain reaction (PCR) for immunoglobulin heavy chain gene rearrangement study showed a clonal gene rearrangement. The findings indicated EBV+LPD of the bladder. Primary lymphoma of bladder is rare and primary EBV+LPD of the bladder has not been previously described. Potential misdiagnosis of poorly differentiated urothelial carcinoma can occur and accurate diagnosis depends on comprehensive immunohistochemical and molecular workups. |
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