| CASE REPORT |
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| Year : 2008 | Volume
: 24
| Issue : 4 | Page : 555-557 |
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Severe acute tumor lysis syndrome in patients with germ-cell tumors
Guilherme Alvarenga Feres1, Jorge Ibrain Figueira Salluh1, Carlos Gil Ferreira2, Marcio Soares1
1 Intensive Care Unit, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil
2 Department of Clinical Research, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil
Correspondence Address:
Marcio Soares
Intensive Care Unit, Instituto Nacional de Câncer (INCA), 10o Andar, Praça Cruz Vermelha, 23-10o Andar, Rio de Janeiro, RJ 20230-130
Brazil
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-1591.44267
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Germ-cell tumors are a high-proliferative type of cancer that may evolve to significant bulky disease. Tumor lysis syndrome is rarely reported in this setting. The reports of three patients with germ-cell tumors who developed severe acute tumor lysis syndrome following the start of their anticancer therapy are presented. All patients developed renal dysfunction and multiorgan failure. Patients with extensive germ-cell tumors should be kept on close clinical and laboratory monitoring. Physicians should be aware of this uncommon but severe complication and consider early admission to the intensive care unit for the institution of measures to prevent acute renal failure. |
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