Indian Journal of Urology Users online:633  
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size

Year : 2007  |  Volume : 23  |  Issue : 4  |  Page : 390-402

Recent advances in pediatric uroradiology

Division of Pediatric Urology, Surgical Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA

Correspondence Address:
Pramod P Reddy
Division of Pediatric Urology (MC -5037) Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave Cincinnati, Ohio 45229
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.36713

Rights and Permissions


Pediatric Urology is a surgical subspecialty that is very dependent upon radiographic imaging as the majority of the genitourinary (GU) tract is internally located. Technological advances in various imaging modalities (e.g. ultrasonography, nuclear medicine, CT and MRI) have aided in our ability to visualize and evaluate the functionality of the GU tract, enabling the diagnosis of various disease processes that affect the genitourinary system. Collectively the advances in uro-radiology have improved our understanding of the natural history of many conditions that involve the GU tract. As a result of these newer imaging modalities, some of the more traditional techniques have assumed a limited role in the diagnostic evaluation of the pediatric GU patient (e.g. intravenous urography).
The purpose of this article is to review the advances in radiographic imaging, in particular the cross-sectional imaging modalities and discuss their utility (appropriate indications and application) in Pediatric Urology, so that the reader can maximize the diagnostic yield of these studies. For a thorough review of any of the imaging modalities discussed in this article and their utility in the practice of pediatric urology, I would direct the readers to articles in the radiological literature that are specific to that technology. Besides the obvious technological advances in imaging modalities, this review also discusses the attention to radiation safety for the pediatric patient that every physician who orders a diagnostic imaging study in a child should be aware of.

Keywords: Imaging, pediatric, uroradiology

How to cite this article:
Reddy PP. Recent advances in pediatric uroradiology. Indian J Urol 2007;23:390-402

How to cite this URL:
Reddy PP. Recent advances in pediatric uroradiology. Indian J Urol [serial online] 2007 [cited 2021 Aug 6];23:390-402. Available from:

The field of radiology has evolved immensely over the course of the last 112 years since Wilhelm R φntgen took the first radiographic image of his wife's hand. The exploding field of diagnostic imaging is one of the most rapid and remarkable examples of translational research; bench to bedside research. There are now multiple modalities available to image the human body in great detail, which we as surgeons can use to improve the outcomes for the patients that we have the privilege of treating. The indications for diagnostic imaging usually depend upon the clinical presentation and the age of the patient. Frequently more than one imaging technique is required to fully evaluate the anatomy and physiology of the genitourinary (GU) tract. At the end of this article I will provide a pictorial review of the imaging modalities discussed along with the clinical history of the patients whose radiographic results are presented.

The various imaging modalities utilized in the field of Pediatric Urology include:

  • Plain radiography
  • Contrast studies (with fluoroscopy)
  • Ultrasound (US)
  • Computerized tomography (CT scans)
  • Nuclear medicine imaging
  • Magnetic resonance imaging (MRI)
  • Rotational fluoroscopic tomography (RFT)
  • Positron emitted tomography (PET scan)

   Plain Radiography Top

Plain radiographs utilize the difference in radiographic density of the various body parts to create an image or a radiograph. Traditionally these images were captured on X-ray film, however, nowadays, most institutions have implemented film-less digital imaging systems. The advantages of this shift in technology are the improved resolution of the images and the ability to instantly and remotely share access to these images using a picture archiving and communication system (PACS). One of the main advances of this imaging modality has been an increased awareness of the danger of cumulative radiation exposure in the pediatric patient (especially in children with chronic health conditions that require long-term follow-up and repeated imaging). The risk of developing a lethal cancer from radiation exposure in children is theorized to be two to four times higher than for adults per dose unit. [1],[2] While the exact reasons for the significant differences in the risk of developing neoplasms based on age are unclear, it is thought to be due to a combination of the following facts:

  • Children have greater cell proliferation rates, especially during physiological growth spurts and are therefore much more radiosensitive than adults.
  • Children have longer life expectancy from the time of the radiation exposure, allowing for radiation-induced chromosomal mutations to become clinically relevant.
  • For any given radiographic procedure, the effective radiation dose is larger in a small infant than in an adult.

In the USA. numerous national societies have mandated new guidelines for the dosimetry in pediatric patients, with the introduction of the 'ALARA' principle, which mandates that doses should be As Low As Reasonably Achievable. [3] The reduced dosimetry balances the risk of radiation exposure to the patient with the need for adequate imaging quality. Finally, I should state that in cases where diagnostic study is positively indicated, the risk of the procedure is far outweighed by the potential health benefit of appropriate diagnosis and treatment and no child should be denied appropriate diagnostic evaluation.

The primary indications for plain radiographic imaging in pediatric urology are:

  • Two-positional abdominal plain film or KUB (Kidney-Ureter-Bladder) [Figure - 1] to visualize any radio-opaque objects in the GU tract or in the abdomen.

    . Evaluate the structure of the spine

    . Evaluate retroperitoneal air and fat-fascial planes (abscess, infection, perforation)

    . Detect air in the GU tract or free air in the abdomen

    . Impacted feces (constipation)

    . Calcifications (urolithiasis)

    . Detect retained foreign bodies

    . Evaluate the position of stents or drains

  • Plain film X-ray of the pelvis

    . To evaluate the bony pelvis and the terminal spine

    . Evaluate for any calcifications or foreign body within/adjacent to the urinary bladder or urethra

   Contrast Studies Top

Diagnostic imaging modalities that employ contrast agents, permit visualization of the structural details of internal organs that would not otherwise be demonstrable. There have been several advances in this aspect of diagnostic imaging, including improved contrast agents and improvements in the fluoroscopy equipment used in this modality (low dosimetry, digital equipment and rotational fluoroscopy). Modern contrast agents contain as much as 2,000 times the iodine as the total physiological body content, but these agents are rapidly and safely cleared from the body without any adverse effects to the patient, in most instances. Contrast agents are categorized according to their chemical structure and relative osmolality, into high and low osmolality agents. These contrast agents are further subdivided into ionic and nonionic agents. The high-osmolality agents are associated with a higher risk of adverse events (nephrotoxicity, idiosyncratic reactions), while the low-osmolality are better tolerated with less discomfort and fewer cardiovascular and anaphylactic-type reactions, however, they are much more expensive. [4]

The common studies employed in pediatric urology that require the administration of contrast agents include:

  • Intravenous urography (IVU)
  • Voiding cystography (VCUG - Voiding cystourethrogram, MCUG - Micturating cystourethrogram)
  • Retrograde urethrogram (RUG)
  • Cystogram
  • Whitaker test
  • Angiography
  • Computed tomography
  • Interventional radiological studies (Antegrade pyelography)

   Intravenous Urography or Intravenous Pyelography Top

Intravenous urography (IVU) (aka IVP) or excretory urography is one of the oldest uroradiologic imaging modalities. Until the advent of MR urography and CT urography, this was the only means by which to evaluate both the morphology and the function of the upper urinary tract. However, due to concerns of radiation exposure in children and the advent of the newer modalities, the indications for IVU have evolved and it should be tailored to answer the individual patient's clinical query. [5],[6]

The current indications for IVU in a pediatric patient are:

  • Hematuria associated with renal colic (although a non-contrast CT scan [stone protocol] is deemed to have higher diagnostic accuracy in these cases).
  • Symptomatalogy suggesting specific congenital anomalies (e.g. constant dribbling of urine in a girl - ? ectopic ureter ).
  • Abnormal findings on a renal ultrasound that warrant further evaluation (e.g. calyceal diverticula).
  • History of papillary necrosis, tuberculosis of the GU tract, medullary sponge kidney.

   Voiding Cystourethrography Top

Voiding cystourethrography (VCUG or MCUG) remains the mainstay of uroradiology in children and should be performed after a thorough sonographic evaluation of the kidneys and bladder. The 'ALARA' principle for reducing radiation exposure has led to the use of digital fluoroscopes optimized for use in children that are capable of pulsed fluoroscopy but maintain diagnostic image quality. [7],[8] The primary indications for performing a VCUG are a history of a febrile urinary tract infection (UTI) or prenatally detected hydronephrosis. The VCUG is the only diagnostic imaging modality that can reliably directly demonstrate posterior urethral valves. An adequately performed VCUG provides anatomic and functional information about the urinary bladder (bladder capacity, vesico-ureteral reflux (VUR), trabeculations, diverticula or ureteroceles) [Figure - 2]d and the urethra (valves, strictures, incomplete relaxation of the sphincter or prostatic utricle).

The selection of contrast media is critical to the quality of the study obtained; the medium must be radiopaque, sufficiently viscous to demonstrate bladder and urethral anatomy. It must also be well tolerated by the urothelium and harmless in case it does gain intravascular access. The VCUG in addition to detecting VUR, also aids in the grading and classification of the VUR [Figure - 2]d and e. [9] Additionally, in the presence of VUR, the VCUG can assess for the presence of intrarenal reflux (reflux of contrast into the collecting ducts or ducts of Bellini, this finding automatically raises the grade of VUR to grade 5/5) [Figure - 3]a and for drainage of the refluxed material to exclude concomitant uretero-vesical junction (UVJ) or uretero-pelvic junction (UPJ) obstruction, especially in the high grades of VUR.

The scout film of the VCUG also aids in the diagnosis of constipation, that should raise the suspicion of dysfunctional elimination syndrome or any bony abnormalities that might suggest spinal cord anomalies (tethered spinal cord or occult myelomeningocele. [10] The post-void films of the VCUG are useful in demonstrating 'vaginal voiding', incomplete emptying of the urinary bladder suggesting some anatomic or functional obstruction of the bladder neck or urethra (e.g. detrusor sphincteric dysfunction) and also reflux of contrast into the prostatic or ejaculatory ducts suggesting high-pressure voiding [Figure - 3]b. It has been shown that there is a diagnostic advantage to infusing warmed contrast medium versus room temperature contrast medium. [11]

Frequently, children referred for VCUG are already on treatment with antibiotics (either treatment or prophylactic doses), however, children with a prosthetic heart valve, a valvular lesion, a septal defect or patent ductus should receive prophylactic antibiotics to prevent endocarditis.

In order to increase the diagnostic yield of detecting VUR, the radiologist should, in children with a high degree of clinical suspicion of having VUR, perform a cyclical VCUG. This involves multiple cycles of bladder filling and emptying. However, one must keep in mind that each cycle incrementally increases the radiation exposure of the child. [12],[13] Typically the VCUG is obtained several weeks after a febrile UTI, however it can also be safely performed during an active UTI under the protection of intravenous antibiotics. In fact there is a subset of patients that only develop secondary VUR when actively infected.

   Retrograde Urethrogram and Cystogram Top

These diagnostic studies are mainly indicated in the evaluation of GU trauma, however due to the rapid acquisition of images by a spiral CT scan, the utility of these studies has been significantly reduced. Most cystograms in trauma patients are now CT cystograms. To ensure an adequate study in an adult patient a minimum of 300 ml of contrast should be instilled in the bladder, for the pediatric patient the bladder should be filled to the age appropriate expected bladder capacity [(age in years + 2) x 30 mL]. [14]

Retrograde urethrograms (RUGs) are also useful in defining the extent and nature of urethral stricture disease in conjunction with a cystogram. In cases of patients with a history of multiple urethroplasties for a hypospadiac urethra, an RUG can delineate the existing urethral anatomy prior to reconstructive surgery. We usually perform elective cystograms utilizing the three-dimensional rotational fluoroscopic technique (described in detail later in this article). This technique offers a significant enhancement of the anatomic detail obtained from the cystogram and aids in the diagnosis and preoperative surgical plan.

   Whitaker Test (Antegrade Perfusion Pressure Flow Test) Top

The Whitaker test is an invasive test performed to evaluate the dynamics of either a UPJ obstruction or a UVJ obstruction. This study involves percutaneous access into the pelvicalyceal system. Contrast medium is instilled into the collecting system while monitoring the intrarenal and intravesical pressure. The opening pressure of the renal pelvis or the ureter is evaluated and can aid in the diagnosis of obstruction at these sites. The Whitaker test has limited applicability in the pediatric age group (due to the development of the noninvasive diuretic renogram), however it can be useful in instances of recurrent UPJ obstruction after a pyeloplasty or when the diuretic renogram is non-diagnostic in a symptomatic patient in whom a UPJ obstruction is clinically suspected. [15],[16]

   Angiography Top

Due to the invasive nature of this imaging modality it has very limited application in pediatric uroradiology. The main indications include:

  • Diagnosis of arterio-venous malformations in instances of gross hematuria (post-traumatic, congenital or after renal biopsy)
  • It can be both diagnostic and therapeutic (permitting selective embolization of injured vessels) in certain instances of renal trauma with segmental artery bleeding
  • Evaluation of reno-vascular hypertension
  • Evaluation of pseudo-aneurysm in renal transplants

   Ultrasound Top

Medical ultrasonography (US) was introduced after the Second World War and is now the imaging modality of choice in pediatric uroradiology due to its noninvasive nature. It is mainly used as the primary screening diagnostic modality that then dictates further imaging strategies. Due to its noninvasive and non-ionizing nature it can be used for repeated follow-up imaging of the GU tract. The current generation of US equipment has benefited immensely from the advances in microchip technology and electronic miniaturization, allowing unprecedented image quality at greater tissue depths and resolution.

Indications for US evaluations include:

  • Prenatal imaging (the GU tract can be imaged as early as 14-16 weeks post-conception, with renal parenchymal differentiation seen by 20 weeks of gestation) [17]
  • Screening of the GU tract for congenital anomalies in neonates with a history of an abnormal prenatal US (or a sibling with VUR)
  • Anatomic survey of the retro-peritoneum in a child presenting with an abdominal mass (evaluate the kidney and adrenal gland for tumors or cystic masses)
  • Evaluation of a febrile UTI (color Doppler imaging to detect pyelonephritis or hematuria [18]
  • Evaluation of renal colic (presence of ureteral jets suggests insignificant obstruction if any)
  • Follow-up evaluation of known GU tract anomalies (e.g. renal cyst, renal duplication, renal dysplasia, hydronephrosis, hydroureter, ureterocele, urachal remnants) [Figure - 2]abc, & [Figure - 5]ab
  • Evaluation of blood flow patterns of the kidney with color Doppler (to detect pyelonephritis, renal vein thrombosis and to ensure renal transplant viability - calculate the resistive index)
  • Post void residual evaluation in patients with dysfunctional voiding
  • Evaluation of the internal genitalia (in cases of intersex/ambiguous genitalia); in female neonates, the endocrinological stimulation by the maternal hormones causes the uterus to be visualized as a bulbous enlarged organ with a prominent endometrial stripe
  • Evaluation of testes (structure and blood flow patterns - torsion, tumors) [Figure - 8]b, c, d
  • Evaluation of urethral disease (transperineal US to evaluate for PUV or urethral stricture disease) [19]
  • Evaluation of constipation [20]
  • Evaluation of the spinal cord in cases of suspected tethered cord (up to six months - after that the vertebral bodies are calcified and an MRI is required) [21]
  • Intraoperative localization of soft tissue lesions (testicular, adrenal or renal lesions)

The differential diagnosis of a renal mass in the neonatal patient, that warrants an evaluation with ultrasonography includes:

  • Urinary tract obstruction
  • Uretero-pelvic junction (UPJ) obstruction
  • Uretero-vesical junction (UVJ)obstruction
  • Posterior Urethral valves (PUV)
  • Urogenital sinus
  • Cloacal anomalies
  • Reflux with hydronephrosis
  • Multicystic dysplastic kidney (MCDK)
  • Congenital mesoblastic nephroma
  • Nonpolycystic nephromegaly
  • Neuroblastic nephroma
  • Renal cystic disease

There has been a significant push to obviate the need for invasive ionizing radiographic studies (VCUG or nuclear cystograms) for the detection of VUR by using contrast enhanced US (cystosonography with echocontrast). [22],[23] While there have been many studies that have demonstrated a proof of concept, this modality has not yet attained widespread clinical applicability.

   Computerized Tomography Scans Top

Computerized tomography (CT) has limited application in the evaluation of the GU tract of neonates due to the lack of significant amounts of intraperitoneal and retroperitoneal fat; this necessitates the administration of contrast to visualize solid organs and vessels. However, CT imaging has become vital in the diagnostic evaluation of urolithiasis (non-contrast CT scan - stone protocol) and in cases of abdominal trauma [Figure - 6]b and c. The urinary tract is the second most commonly injured organ system in children (the central nervous system is the most commonly injured organ in blunt trauma). Up to 5% of all trauma-related fatalities in the pediatric age group in the US are secondary to significant GU trauma. Preexisting GU abnormalities predispose children to renal injuries from blunt trauma, these include hydronephrosis, tumors or compensatory hypertrophy.

Computerized tomographic imaging is a procedure that involves a high radiation dose.

[Table - 1] demonstrates that one abdominal CT scan involves an effective radiation dose equal to 500 chest radiographs and is the equivalent of the average national (in the US) background environmental radiation received over a period of more than three years.

Effectively, a single abdominal CT scan has the equivalent radiation exposure as 500 chest X-rays. [25] The importance of reducing the radiation dose in pediatric patients has already been discussed. As a rule of thumb, the lifetime cancer mortality risk attributable to the radiation exposure from a single abdominal CT examination in a one-year-old child is of the order of one in a 1000; it can be significantly reduced if every effort is made by the radiologist to reduce the radiation dose by adjusting the mAs and the kVp to the size of the patient. [26] The advent of helical CT scanners has allowed for cross-sectional imaging in children, with a very short exposure time that decreases the overall radiation exposure to the patient and obviates the need for sedation. The latest generation of multidetector CT scanners (MDCT) allow for rapid and complete imaging of the abdominal cavity with accurate definition of the retroperitoneum. When contrast is required oral contrast should be ideally given two to five hours prior to scanning while intravenous contrast is administered during the actual image acquisition. The MDCT scanners acquire tomograms in thicker slices than prior generations of scanners, thereby exposing the patient to less radiation per scan and permitting the reconstruction of thin slices with fine detail.

Computerized tomography imaging without contrast allows the visualization of calcifications within the GU tract (urolithiasis, nephrocalcinosis and metastatic calcifications), whereas contrast enhanced CT imaging enables the demonstration of infections or masses within the GU tract.

Multidetector CT has in most instances replaced IVP as the contrast imaging of choice for the GU tract. When interpreting the pediatric CT scan one should bear in mind that most children have significantly less retroperitoneal fat than adults, this does alter some of findings that are considered pathognomonic for certain conditions (e.g. retroperitoneal streaking in the peri-renal or peri-ureteral region is considered a good indicator of a high-grade obstruction in adults, this is not always evident in children even with complete obstruction). The visualization of the intraperitoneal organs is an additional benefit of the CT scan especially in the evaluation of acute flank pain, as it demonstrates the appendix and the adnexal organs (appendicitis, pelvic inflammatory disease). [27],[28] Sagittal, coronal or three-dimensional reformatting of the two-dimensional tomographic images of a CT scan provides enhanced diagnostic utility of this modality.

   Nuclear Medicine Imaging Top

Diagnostic imaging with radionuclide tracers offers functional information that is not attainable with traditional radiographic imaging, in addition to reduced radiation exposure. Nuclear imaging is usually reserved for the older pediatric patient as it has very limited utility in the neonatal period (due to the inability of these tests to provide adequate anatomical detail). The most common nuclear imaging studies include radionuclide cystography (RNC), cortical renal scintigraphy and diuretic renography (Lasix Renogram).

Radionuclide cystography (RNC) for diagnosing VUR [29] is indicated in instances of:

  • Family screening for vesicoureteral reflux
  • Follow-up of known VUR [Figure - 4]
  • Follow-up of patients after anti-reflux surgery (e.g. ureteral reimplantation or Deflux™ injection)

The benefits of RNC over VCUG are:

  • It has a significantly lower radiation dose
  • It provides continuous monitoring of bladder filling and voiding

The RNC does not provide the same anatomic details that the VCUG is capable of demonstrating, e.g., presence of a para-ureteral diverticulum, bladder trabeculation, spinal anomalies, etc.

Renal cortical scanning is used to identify anomalies of the upper urinary tract that affect renal function e.g. multicystic dysplasia and pyelonephritic scarring. Tubular transport tracers include Technetium [ 99m Tc], Mercaptoacetyltriglycine [MAG-3] and 99m Tc Dimercaptosuccinic acid [DMSA]; these agents identify renal cortical tissue and can localize ectopic renal tissue. The DMSA scan is the most accurate imaging modality for the diagnosis of acute pyelonephritis, the decreased accumulation of the tracer in the renal parenchyma is secondary to inflammatory edema, the resultant deceased blood flow and cellular enzymatic activity. [30] When evaluating a neonate, it is preferable to use the cortical agents as these patients usually have a low glomerular filtration rate.

Diuretic Renography requires the use of glomerular filtration tracers ( 99m Tc Diethylenetriaminepenta-acetic acid [DTPA]) and is mainly used to evaluate hydronephrosis as it can distinguish obstructive conditions from physiological hydronephrosis (secondary to either ureteropelvic junction obstruction or urterovesical junction obstruction). The 'Well Tempered Renogram' is the result of standardization of this study by the Pediatric Imaging Council of the Society of Nuclear Medicine. [31],[32] The procedure protocol calls for very specific hydration parameters and the presence of an indwelling catheter in the bladder. These studies provide information about the differential function of the kidneys and also the drainage time of the collecting system (t 1/2) [Figure - 5]c and d.

   Magnetic Resonance Imaging Top

Magnetic resonance (MR) imaging of the abdomen in the hands of an experienced radiologist can provide images of the GU tract that have exquisite detail. The limitations of MR imaging are:

  • Motion artifact (vascular pulsations, peristalsis, respiration motion)
  • Need for sedation or general anesthesia in children less than seven years of age
  • Expensive equipment and infrastructure (special rooms that don't interfere with the magnetic field of the human body, computer archiving systems to store the imaging data) often limit the accessibility to this imaging modality.

Magnetic resonance imaging is the modality of choice for pelvic imaging (internal genitalia, ectopic ureters) [Figure - 7]. Magnetic resonance urography is a rapidly expanding field of study; due to the absence of radiation exposure to the patient, it is being used to evaluate the presence of ureteropelvic junction obstruction. [33] Imaging of fetal anatomy in-utero while possible with US, is significantly enhanced with fetal MR imaging (FMRI). This is attributable to the fact that the conditions that hinder US imaging i.e. a lack of fluid and patient obesity are almost always present when dealing with in-utero GU pathology. Fetal MR imaging is still considered to be an experimental imaging protocol. At our institution we perform FMRI after the 18th week of gestation and utilize MRI sequences such as 'Single Shot Fast Spin Echo (SSFSE)' with T2 imaging. The image acquisition is very fast, permitting these studies to be performed without the need for maternal sedation. In a review of our institutional series of over 100 studies, FMRI had a 100% accuracy rate compared to a 55% accuracy rate for prenatal US. [34],[35] Fetal MR imaging should be considered as a complementary study for prenatal US and not a replacement [Figure - 10].

   Rotational Fluoroscopic Tomography Top

Rotational fluoroscopic tomography (RFT) involves continuous digital image acquisition as a fluoroscopic c-arm rotates around a patient during either intravascular or intraluminal contrast injection. Subsequent three-dimensional (3D) reconstructions can be performed within four minutes of image acquisition. Rotational fluoroscopic tomography technology is a powerful real time tool with diagnostic and therapeutic applications. It provides enhanced spatial orientation, improved diagnostic capability and assists in interventional radiology or surgical planning. At our institution we perform RFT and 3D reconstructions in a Philips Integris Allura™ interventional suite. Studies that can be performed with RFT include antegrade pyelography, evaluation of UPJ or UVJ obstruction. [36],[37] Non-urological applications include percutaneous transhepatic cholangiography, evaluation of recto-urethral fistulae, anal atresia and comminuted fractures. The radiation exposure of an RFT study is one-sixth that of a CT scan [Figure - 6]f and [Figure - 9]b.

   Positron Emitted Tomography Scan Top

Positron emitted tomography (PET) scan is a diagnostic examination that involves the acquisition of physiologic images based on the detection of radiation from the emission of positrons (tiny particles emitted from a radioactive substance, usually a glucose analog 2-deoxy-2-[18F] fluoro-D-glucose (FDG) that is administered to the patient). Positron emitted tomography scans permit the study of organ function by detecting alterations in biochemical processes that suggest disease before changes in anatomy are apparent with other imaging tests, such as CT or MRI. The PET scans are used most often to detect cancer and to examine the effects of cancer therapy by characterizing biochemical changes in the cancer [Figure - 8]. [38] Proper interpretation of FDG PET images requires knowledge of the normal physiologic distribution of the tracer, frequently encountered physiologic variants and benign pathologic causes of FDG uptake that can be confused with a malignant neoplasm. [39] Different colors or degrees of brightness on a PET image represent different levels of tissue or organ function. For example, because healthy tissue uses glucose for energy, it accumulates some of the tagged glucose, which will show up on the PET images. However, cancerous tissue, which uses more glucose than normal tissue, will accumulate more of the substance and appear brighter than normal tissue on the PET images. The PET scans are mainly utilized in the evaluation of retroperitoneal tumors and renal tumors in the pediatric GU patient. Ideally the PET scan is utilized as part of a larger diagnostic work-up, which permits comparison of the PET scan with other imaging studies, such as CT or MRI, enhancing the diagnostic accuracy of the PET scan.

In summary pediatric imaging continues to evolve as technological innovations are incorporated into clinical imaging modalities. A thorough understanding of the contemporary imaging techniques, their indications and limitations will enable the surgeon to tailor the appropriate combination of diagnostic tests for any given patient, bearing in mind the potential problems and costs associated with these imaging modalities. When treating pediatric patients, it is the responsibility of all healthcare professionals to ensure that the 'ALARA' principle is followed whenever radiographic studies are obtained.

   References Top

1.ICRP 60. International Commission on Radiological Protection. 1990 Recommendations of the International Commission on Radiological Protection. Pergamon Press: Oxford; 1990.  Back to cited text no. 1    
2.BEIR-V. Committee on the Biological Effects of Ionizing Radiations. Health effects of exposure to low levels of ionizing radiation. BEIR V report. National Academy Press: Washington; 1990.  Back to cited text no. 2    
3.Willis CE, Slovis TL. The ALARA concept in pediatric CR and DR: Dose reduction in pediatric radiographic exams--a white paper conference executive summary. Pediatr Radiol 2004;34:S162-4.  Back to cited text no. 3    
4.Maddox TG. Adverse reactions to contrast material: Recognition, prevention and treatment. Am Fam Physician 2002;66:1229-34.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Choyke Pl. The urogram: Are rumors of its death premature? Radiology 1992;184:33-4.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Dacher JN. Diagnostic procedures excluding MRI, nuclear medicine and video urodynamics. In : Fotter R, editor. Pediatric uroradiology. Springer: Berlin, Heidelberg, New York: 2001. p. 1-14.  Back to cited text no. 6    
7.O'Connor SJ, Wirt MD, Ruess L. Image capture vs spot radiographic exposures for the detection and grading of vesicoureteral reflux in children with digital fluoroscopy. Pediatr Radiol 2004;34:S50.  Back to cited text no. 7    
8.Cleveland RH, Constantinou C, Blickman JG, Jaramillo D, Webster E. Voiding cystourethrography in children: Value of digital fluoroscopy in reducing radiation dose. AJR Am J Roentgenol 1992;158:137-42.  Back to cited text no. 8    
9.Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-M φbius TE. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol 1985;15:105-9.  Back to cited text no. 9    
10.Koff SA, Wagner TT, Jayanthi VR. The relationship among dysfunctional elimination syndromes, primary vesicoureteral reflux and urinary tract infections in children. J Urol 1998;160:1019-22.  Back to cited text no. 10  [PUBMED]  
11.Goodman TR, Kilborn T, Pearce R. Warm or cold contrast medium in the micturating cystourethrogram (MCUG): Which is best? Clin Radiol 2003;58:551-4.  Back to cited text no. 11  [PUBMED]  [FULLTEXT]
12.Paltiel HJ, Rupich RC, Kiruluta HG. Enhanced detection of vesicoureteral reflux in infants and children with the use of cyclic voiding cystourethrography. Radiology 1992;184:753-5.  Back to cited text no. 12  [PUBMED]  [FULLTEXT]
13.Gelfand MJ, Koch BL, ELgazzar AH, Gylys-Morin VM, Gartside PS, Torgerson CL. Cyclic cystography: Diagnostic yield in selected pediatric populations. Radiology 1999;213:118-20.  Back to cited text no. 13  [PUBMED]  [FULLTEXT]
14.Koff SA. Estimating bladder capacity in children. Urology 1983;21:248.  Back to cited text no. 14  [PUBMED]  
15.Whitaker RH. Methods of assessing obstruction in dilated ureters. Br J Urol 1973;45:15-22.  Back to cited text no. 15  [PUBMED]  
16.Jaffe RB, Middleton AW Jr. Whitaker test: Differentiation of obstructive and non-obstructive uropathy. AJR Am J Roentgenol 1980;134:9-15.  Back to cited text no. 16  [PUBMED]  [FULLTEXT]
17.Garrett WJ, Warren PS, Fisher CC. Ultrasound in the diagnosis and management of urinary tract disorders in the fetus. Ultrasound Med Biol 1984;10:473-83.  Back to cited text no. 17  [PUBMED]  
18.Winter DW. Power doppler sonographic evaluation of acute pyelonephritis in children. J Ultrasound Med 1996;15:91-6.  Back to cited text no. 18    
19.Good CD, Vinnicombe SJ, Minty IL, King AD, Mather SJ, Dicks-Mireaux C. Posterior urethral valves in male infants and newborns: Detection with US of the urethra before and during voiding. Radiology 1996;198:387-91.  Back to cited text no. 19  [PUBMED]  [FULLTEXT]
20.Singh SJ, Gibbons NJ, Vincent MV, Sithole J, Nwokoma NJ, Alagarswami KV. Use of pelvic ultrasound in the diagnosis of megarectum in children with constipation. J Pediatr Surg 2005;40:1941-4.  Back to cited text no. 20  [PUBMED]  [FULLTEXT]
21.Dick EA, Patel K, Owens CM, De Bruyn R. Spinal ultrasound in infants. Br J Radiol 2002;75:384-92.  Back to cited text no. 21  [PUBMED]  [FULLTEXT]
22.Bosio M. Cystosonography with echocontrast: A new imaging modality to detect vesico-ureteric reflux in children. Pediatr Radiol 1998;28:250-5.  Back to cited text no. 22  [PUBMED]  [FULLTEXT]
23.Valentini AL, Salvaggio E, Manzoni C, Rendeli C, Destito C, Summaria V, et al . Contrast-enhanced gray-scale and color Doppler voiding urosonography versus voiding cystourethrography in the diagnosis and grading of vesicoureteral reflux. J Clin Ultrasound 2001;29:65-71.  Back to cited text no. 23  [PUBMED]  
24.Hall EJ. Lessons we have learned from our children: Cancer risks from diagnostic radiology. Pediatr Radiol 2002;32:700-6.  Back to cited text no. 24  [PUBMED]  [FULLTEXT]
25.Shrimpton PC, Jessen KA, Geleijns J. Reference doses in computed tomography. Radiat Prot Dosimetry 1998;80:55-9.  Back to cited text no. 25    
26.Brenner DJ, Elliston CD, Hall EJ, Berdon W. Estimated risks of radiation induced fatal cancer from pediatric CT. AJR Am J Roentgenol 2001;176:289-96.  Back to cited text no. 26    
27.Miller OF, Kane CJ. Unenhanced helical computed tomography in the evaluation of acute flank pain. Curr Opin Urol 2000;10:123-9.   Back to cited text no. 27  [PUBMED]  [FULLTEXT]
28. Lowe LH, Penney MW, Stein SM, Heller RM, Neblett WW, Shyr Y, et al . Unenhanced limited CT of the abdomen in the diagnosis of appendicitis in children: Comparison with sonography. AJR Am J Roentgenol 2001;176:31-5.  Back to cited text no. 28  [PUBMED]  [FULLTEXT]
29.Conway JJ, King LR, Belman AB, Thorson T Jr. Detection of vesicoureteral reflux with radionuclide cystography: A comparison study with roentgenographic cystography. Am J Roentgenol Radium Ther Nucl Med 1972;115:720-7.  Back to cited text no. 29  [PUBMED]  
30.Rushton HG, Majd M. Dimercaptosuccinic acid renal scintigraphy for the evaluation of pyelonephritis and scarring: A review of experimental and clinical studies. J Urol 1992;148:1726-32.  Back to cited text no. 30  [PUBMED]  
31.Conway JJ. Well-tempered diuresis renography: Its historical development, physiologic and technical pitfalls and standardized technique protocol. Semin Nucl Med 1992;22:74-84.  Back to cited text no. 31  [PUBMED]  
32.Conway JJ, Maizels M. The "well tempered" diuretic renogram: A standard method to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis: A report from combined meetings of The Society for Fetal Urology and members of The Pediatric Nuclear Medicine Council--The Society of Nuclear Medicine. J Nucl Med 1992;33:2047-51.  Back to cited text no. 32  [PUBMED]  [FULLTEXT]
33.Kirsch AJ, McMann LP, Jones RA, Smith EA, Scherz HC, Grattan-Smith JD. Magnetic resonance urography for evaluating outcomes after pediatric pyeloplasty. J Urol 2006;176:1755-61.  Back to cited text no. 33  [PUBMED]  [FULLTEXT]
34.Miller OF, Lashley DB, Mcaleer IM, Kaplan GW. Diagnosis of urethral obstruction with prenatal magnetic resonance imaging. J Urol 2002;168:1158-9.  Back to cited text no. 34  [PUBMED]  [FULLTEXT]
35.Hsieh K, O'Loughlin MT, Ferrer FA. Bladder exstrophy and phenotypic gender determination on fetal magnetic resonance imaging. Urology 2005;65:998-9.  Back to cited text no. 35  [PUBMED]  [FULLTEXT]
36.Hardy JE, Dodds SR, Roberts AD. An objective evaluation of the effectiveness of different methods of displaying three-dimensional information with medical x-ray images. Invest Radiol 1996;31:433-45.  Back to cited text no. 36  [PUBMED]  [FULLTEXT]
37.Law EM, Little AF, Salanitri JC. Non-vascular intervention with real-time CT fluoroscopy. Australas Radiol 2001;45:109-12.  Back to cited text no. 37  [PUBMED]  [FULLTEXT]
38.Kaneta T, Hakamatsuka T, Yamada T, Takase K, Sato A, Higano S, et al . FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature. Ann Nucl Med 2006;20:79-82.  Back to cited text no. 38  [PUBMED]  
39.Abouzied MM, Crawford ES, Nabi HA. 18F-FDG Imaging: Pitfalls and artifacts. J Nucl Med Technol 2005;33:145-55.  Back to cited text no. 39  [PUBMED]  [FULLTEXT]


  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6], [Figure - 7], [Figure - 8], [Figure - 9], [Figure - 10]

  [Table - 1]

This article has been cited by
1 Hormone-secreting large adrenal ganglioneuroma in an adult patient: A case report and review of literature
Cihangir Erem,Mehmet Fidan,Nadim Civan,Umit Cobanoglu,Fevzi Kangul,Irfan Nuhoglu,Etem Alhan
Blood Pressure. 2013; : 1
[Pubmed] | [DOI]
2 Pediatric urolithiasis: Incidence and surgical treatment
Daradka, I.
Jordan Medical Journal. 2011; 45(1): 102-108


Print this article  Email this article
Previous article Next article


   Next article
   Previous article 
   Table of Contents
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (288 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Plain Radiography
    Contrast Studies
    Intravenous Urog...
    Voiding Cystoure...
    Retrograde Ureth...
    Whitaker Test (A...
    Computerized Tom...
    Nuclear Medicine...
    Magnetic Resonan...
    Rotational Fluor...
    Positron Emitted...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded534    
    Comments [Add]    
    Cited by others 2    

Recommend this journal