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Year : 2001  |  Volume : 18  |  Issue : 1  |  Page : 62-64

Cross-resistance between trimethoprim-sulfamethoxazole and other common antibiotics among urinary isolates of escherichia coli - an in-vitro retrospective analysis

Department of Microbiology, M.S. Rainaiah Medical College (MSRMC) and Teaching Hospital, Bangalore, India

Correspondence Address:
B V Navaneeth
Department of Microbiology, M.S. Ramaiah Medical College and Hospital, Gokula Extension, Bangalore - 560 054
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Source of Support: None, Conflict of Interest: None

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472 non-repetitive urinary isolates of E.coli (349 resistant and 123 sensitive to trimethoprim-sulfametho.xazole) from patients with culture documented UTI were isolated between January 1998-December 1999. Data on antibiograrn of these isolates were fed into WHONET computer program. The relationship between trimethoprim-sulfamethoxazole (T-S) resistance and resistance to other common antimicrobials among E. coli was statistically analyzed by comparing T-S resistant with T-S sensitive isolates against other antimicrobial agents. T-S resistant E.coli were more likely to be resistant to ampicillin, augmentin, cejazolin and norfloxacin (P<0.001) but not for gentanicin and nitrofurantoin (P>0.05). T-S resistance among urinary isolates of E.coli may be a risk fatctor that would likely be associated with resistance to other antimicrobial agents used to treat UTI.

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