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CORRESPONDENCE SECTION
Year : 2001  |  Volume : 17  |  Issue : 2  |  Page : 194-195
 

Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics


Departments of Uro- Nephrology and Statistics, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Anantapur District, Andhra Pradesh - 515134, India

Correspondence Address:
N K Ganesh Prasad
Departments of Uro- Nephrology and Statistics, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Anantapur District, Andhra Pradesh - 515134
India
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Keywords: Creatinine Clearance; Methods; Hypoalbuminaemics.


How to cite this article:
Ganesh Prasad N K, Rao R P, Sivakumar V. Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics. Indian J Urol 2001;17:194-5

How to cite this URL:
Ganesh Prasad N K, Rao R P, Sivakumar V. Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics. Indian J Urol [serial online] 2001 [cited 2021 Jul 24];17:194-5. Available from: https://www.indianjurol.com/text.asp?2001/17/2/194/20281



   Introduction Top


24-hours' endogenous creatinine clearance estimation is a widely accepted method for assessnent of glomerular filtration in clinical practice. This procedure is time con­suming and requires an accurate 24-hours' collection of urine and hospital stay. Hence several formulae have been in vogue for bedside assessment of creatinine clearance, one of them being Cockcroft-Gault (C-G) formula. [1] In the recent literature, Sanaka et al. cited a serum albumin re­lated formula [2] for estimating creatinine clearance which is comparable with C-G formula. However, they mentioned that serum albumin related formula needs further prospec­tive validation in conditions where serum albumin is af­fected. Hence this prospective study on adult nephrotic hypoalbuminaemic subjects, was taken up to study the com­parability between the measured 24-hours' endogenous cre­atinine clearance and the creatinine clearance estimated by the predictive formulae like C-G formula and albumin related formula. 22 Patients with Hypoalbuminaemia (3 or less then 3G% of albumin) with nephrotic proteinuria, sec­ondary to a glomerular disease were included. Male:Female ratio was 14:8. The age ranged between 20 and 59 years. 24-hours' creatinine clearance was measured in the labo­ratory. Predicted creatinine clearance was calculated bas­ing on C-G formula and serum albumin related formula [Table - 1].

C-G Formula :



Serum albumin related Formula:



The creatinine clearance values obtained by all the 3 meth­ods were subjected to statistical study to assess the compa­rability. Generally ANOVA (Analysis of variance) technique is preferred to compare the results obtained from the 3 meth­ods of creatinine clearance estimation, if one presupposes normal distribution and equality of variance. Wilcoxon­Wilcox [3] - a rank test which is good for non-normally dis­tributed data for multiple comparisons was applied in our study. By using this method the calculated absolute differ­ences obtained were represented in the [Table - 2]. From the data, represented in [Table - 2], it is observed that each differ­ence is significant at 5% level marked with single* while each difference which is significant at 1 % level is marked with two**. On the basis of these results, it was concluded that three methods are significantly different in their values. Hence it is better to use 24-hours' endogenous creatinine clearance for the assessment of glomerular filtration rate in hypoalbuminaemic individuals as it has already been a stand­ ard method. The increased body weight due to fluid reten­tion and hypoalbuminaemia have probably affected the calculation as the body weight and serum albumin are used in the calculation of creatinine clearance in the C-G and Serum albumin related formulae.

 
   References Top

1.Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.   Back to cited text no. 1    
2.Sanaka M, Takano K, Shrimakura K, Koike Y, Mineshita S. Serum albumin for estimating creatinine clearance in the elderly with muscle atrophy. Nephron 1996: 73: 137-144.  Back to cited text no. 2    
3.Lothar Sachs. Applied statistics: Handbook of techniques. Springer­Verlag New York: 1984: 555-558.  Back to cited text no. 3    



 
 
    Tables

  [Table - 1], [Table - 2]



 

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