|Year : 2001 | Volume
| Issue : 2 | Page : 194-195
Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics
NK Ganesh Prasad, R Prabhakara Rao, V Sivakumar
Departments of Uro- Nephrology and Statistics, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Anantapur District, Andhra Pradesh - 515134, India
N K Ganesh Prasad
Departments of Uro- Nephrology and Statistics, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Anantapur District, Andhra Pradesh - 515134
Source of Support: None, Conflict of Interest: None
Keywords: Creatinine Clearance; Methods; Hypoalbuminaemics.
|How to cite this article:|
Ganesh Prasad N K, Rao R P, Sivakumar V. Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics. Indian J Urol 2001;17:194-5
|How to cite this URL:|
Ganesh Prasad N K, Rao R P, Sivakumar V. Comparison of creatinine clearance estimation by three different methods in hypoalbuminaemics. Indian J Urol [serial online] 2001 [cited 2023 Feb 1];17:194-5. Available from: https://www.indianjurol.com/text.asp?2001/17/2/194/20281
| Introduction|| |
24-hours' endogenous creatinine clearance estimation is a widely accepted method for assessnent of glomerular filtration in clinical practice. This procedure is time consuming and requires an accurate 24-hours' collection of urine and hospital stay. Hence several formulae have been in vogue for bedside assessment of creatinine clearance, one of them being Cockcroft-Gault (C-G) formula.  In the recent literature, Sanaka et al. cited a serum albumin related formula  for estimating creatinine clearance which is comparable with C-G formula. However, they mentioned that serum albumin related formula needs further prospective validation in conditions where serum albumin is affected. Hence this prospective study on adult nephrotic hypoalbuminaemic subjects, was taken up to study the comparability between the measured 24-hours' endogenous creatinine clearance and the creatinine clearance estimated by the predictive formulae like C-G formula and albumin related formula. 22 Patients with Hypoalbuminaemia (3 or less then 3G% of albumin) with nephrotic proteinuria, secondary to a glomerular disease were included. Male:Female ratio was 14:8. The age ranged between 20 and 59 years. 24-hours' creatinine clearance was measured in the laboratory. Predicted creatinine clearance was calculated basing on C-G formula and serum albumin related formula [Table - 1].
C-G Formula :
Serum albumin related Formula:
The creatinine clearance values obtained by all the 3 methods were subjected to statistical study to assess the comparability. Generally ANOVA (Analysis of variance) technique is preferred to compare the results obtained from the 3 methods of creatinine clearance estimation, if one presupposes normal distribution and equality of variance. WilcoxonWilcox  - a rank test which is good for non-normally distributed data for multiple comparisons was applied in our study. By using this method the calculated absolute differences obtained were represented in the [Table - 2]. From the data, represented in [Table - 2], it is observed that each difference is significant at 5% level marked with single* while each difference which is significant at 1 % level is marked with two**. On the basis of these results, it was concluded that three methods are significantly different in their values. Hence it is better to use 24-hours' endogenous creatinine clearance for the assessment of glomerular filtration rate in hypoalbuminaemic individuals as it has already been a stand ard method. The increased body weight due to fluid retention and hypoalbuminaemia have probably affected the calculation as the body weight and serum albumin are used in the calculation of creatinine clearance in the C-G and Serum albumin related formulae.
| References|| |
|1.||Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41. |
|2.||Sanaka M, Takano K, Shrimakura K, Koike Y, Mineshita S. Serum albumin for estimating creatinine clearance in the elderly with muscle atrophy. Nephron 1996: 73: 137-144. |
|3.||Lothar Sachs. Applied statistics: Handbook of techniques. SpringerVerlag New York: 1984: 555-558. |
[Table - 1], [Table - 2]