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Year : 2001  |  Volume : 17  |  Issue : 2  |  Page : 172-173

Giant renal tumour: Leiomyosarcoma

Departments of Urology & Histopathology, Christian Medical College & Hospital, Vellore, India

Correspondence Address:
Nitin S Kekre
Department of Urology, Christian Medical College & Hospital, Vellore (Tamil Nadu) - 632 004
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Source of Support: None, Conflict of Interest: None

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We report a case of a young adult with an enormous mass lesion arising from the left kidney. His performance status was good despite severe constitutional symptoms. Radical nephrectomy was performed and histopathologi­cally it turned out to be an leiomyosarcoma. He made a good recovery. Surgical extirpation should be carried out to palliate the symptoms specially in young patients even though the prognosis is poor provided the patient has good performance status.

Keywords: Renal Tumours; Sarcoma; Leiomyosarcoma

How to cite this article:
Gupta GG, Singh DR, Korula A, Mehrotra S, Kekre NS. Giant renal tumour: Leiomyosarcoma. Indian J Urol 2001;17:172-3

How to cite this URL:
Gupta GG, Singh DR, Korula A, Mehrotra S, Kekre NS. Giant renal tumour: Leiomyosarcoma. Indian J Urol [serial online] 2001 [cited 2021 Oct 24];17:172-3. Available from:

   Case Report Top

A 44-year-old male presented with gradually increasing abdominal mass of 6-months' duration associated with se­vere constitutional symptoms in the form of significant loss of weight, appetite, breathlessness and difficulty in sitting and walking due to marked distention of abdomen. There was no history of haematuria or flank pain. Physical exami­nation revealed moderate pallor and bilateral pedal oedema. Abdominal examination showed a huge non-tender, firm mass occupying all the quadrants of the abdomen - more on left side. Renal parameters were normal. CT scan showed 27 x 22 X 27 ems heterogenously enhancing mass from left kid­ney [Figure - 1] with areas of calcification involving left renal vein adherent to left colon and hilar lymphadenopathy. Meta­static work-up was negative. Decision of surgical interven­tion was taken to palliate his symptoms. After adequate preoperative preparation, radical nephrectomy with left hemi­colectomy was performed. Postoperative period was unevent­ful. Biopsy revealed high grade leiomyosarcoma of the kidney [Figure - 2] involving hilar lymphnodes. Tumour weighed 7 kgs. Immunocytochemistry for smooth muscle actin and vimentin showed strong cytoplasmic and membrane reactivity but was negative for cytokeratin. Patient is doing well at 6 months' follow-up.

   Comment Top

Renal leiomyosarcoma are rare tumours of the kidney, first reported by Berry. [1] Till 1997 11 cases have been re­ported in English literature. [2] These tumours originate from renal capsule or smooth muscle fibres of renal pelvis or vessels. Common age of onset is 5 th to 8 th decade. Com­monest symptoms are flank pain, haematuria, abdominal mass and other constitutional symptoms may or may not be present. Ultrasound and CT scan reveal solid mass in the kidney not distinguishable from renal cell carcinoma. Patho­logically this tumour mimics sarcomatoid variety of Renal Cell Carcinoma. Immunohistochemical staining helps in dif­ferentiation. Surgery in the form of radical nephrectomy remains the treatment of choice. Pre- and post-operative radio and chemotherapy do not effect the overall survival. [3],[4] These patients have poor prognosis and rarely survive longer than one year.

This case is reported due to its rare occurrence and to highlight the role of surgical intervention in improving the quality of life even in those patients with large and locally advanced but resectable tumours.

   References Top

1.Berry FB. Report of three cases of combined tumours of the kidney in adults. J Med Res 1919: 40: 459.  Back to cited text no. 1    
2.Chen JH, Lee SK. Renal leiomyosarcoma mimicking transitional cell carcinoma. AJR 1997: 169: 312-313.  Back to cited text no. 2    
3.Thirurnavalavan VS. Kennedy CL, Alrufaie HK. Leiomyosarcoma of kidney. Br J Urol 1991: 68: 659-660.  Back to cited text no. 3    
4.Vogelzang NJ, Fremgen AM, Guinan PD. Primary renal sarcomas in adults. Cancer 1993: 71: 804-810.  Back to cited text no. 4    


  [Figure - 1], [Figure - 2]


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