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Figure 2: Small cell carcinoma (a) has tumor cells with scant cytoplasm, fi nely granular chromatin with inconspicuous nucleoli, high mitotic rate and tumor necrosis. Large cell neuroendocrine carcinoma (b) has a solid growth pattern, large zone necrosis, large cell size, low nuclear to cytoplasmic ratio, vesicular chromatin, and frequent mitosis

Figure 2: Small cell carcinoma (a) has tumor cells with scant cytoplasm, fi nely granular chromatin with inconspicuous nucleoli, high mitotic rate and tumor necrosis. Large cell neuroendocrine carcinoma (b) has a solid growth pattern, large zone necrosis, large cell size, low nuclear to cytoplasmic ratio, vesicular chromatin, and frequent mitosis