Indian J Med Microbiol Close
 

A. Synaptic cleft 5 HT and 5-HT neurotransmission are regulated by somatodendritic 5 HT1A autoreceptors, presynaptic 5 HT1B / 1D autoreceptors and a 5 HT transporter re uptake system. As 5-HT is released into the synaptic cleft from presynaptic axonal vesicles, 5 HT transporters again take up and remove 5 HT from the synaptic cleft, preventing overstimulation of the postsynaptic receptors. B. After blockage of 5 HT transporters by acute administration of selective serotonin re-uptake inhibitor class drugs: SSRIs;, synaptic cleft 5 HT increases but is counteracted by activation of 5 HT1A autoreceptors which inhibit further 5 HT release. C. Chronic administration of SSRIs results in greatly enhanced 5-HT neurotransmission due to several adaptive processes which may include presynaptic 5-HT1A and 5-HT1B / 1D receptor desensitisation[35]

A. Synaptic cleft 5 HT and 5-HT neurotransmission are regulated
by somatodendritic 5 HT1A autoreceptors, presynaptic 5 HT1B / 1D autoreceptors and a 5 HT transporter re uptake system. As 5-HT is released into the synaptic cleft from presynaptic axonal vesicles, 5 HT transporters again take up and remove 5 HT from the synaptic cleft, preventing overstimulation of the postsynaptic receptors. B. After blockage of 5 HT transporters by acute administration of selective serotonin re-uptake inhibitor class drugs: SSRIs;, synaptic cleft 5 HT increases but is counteracted by activation of 5 HT1A autoreceptors which inhibit further 5 HT release. C. Chronic administration of SSRIs results in greatly enhanced 5-HT neurotransmission due to several adaptive processes which may include presynaptic 5-HT1A and 5-HT1B / 1D receptor desensitisation[35]