Indian Journal of Urology
SYMPOSIUM
Year
: 2014  |  Volume : 30  |  Issue : 2  |  Page : 189--193

Hormonal manipulation of lower urinary tract symptoms secondary to benign prostatic obstruction


Adita Raja1, Satoshi Hori2, James N Armitage1 
1 Department of Urology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
2 Department of Uro-Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

Correspondence Address:
James N Armitage
Department of Urology, University of Cambridge, Addenbrooke«SQ»s Hospital, Cambridge
United Kingdom

Although the etiology of lower urinary tract symptoms (LUTS) is often multifactorial, a significant proportion of men over the age of 50 suffer from benign prostatic obstruction (BPO) secondary to benign prostatic hyperplasia. Prostate, being an androgen responsive organ is dependent on the male sex hormone, testosterone, for growth. Thus, treatment strategies that manipulate the levels of circulating hormones that influence the level of testosterone and/or prostatic growth represent an important potential option for patients suffering with troublesome LUTS due to BPO. Despite this, the only hormonal treatment that is currently used in daily clinical practice is the 5-alpha reductase inhibitor. In this article, we review the current evidence on the use of the 5-alpha reductase inhibitors finasteride and dutasteride. We also discuss new emerging hormonal manipulation strategies for patients with LUTS secondary to BPO.


How to cite this article:
Raja A, Hori S, Armitage JN. Hormonal manipulation of lower urinary tract symptoms secondary to benign prostatic obstruction.Indian J Urol 2014;30:189-193


How to cite this URL:
Raja A, Hori S, Armitage JN. Hormonal manipulation of lower urinary tract symptoms secondary to benign prostatic obstruction. Indian J Urol [serial online] 2014 [cited 2020 Aug 13 ];30:189-193
Available from: http://www.indianjurol.com/article.asp?issn=0970-1591;year=2014;volume=30;issue=2;spage=189;epage=193;aulast=Raja;type=0