Indian Journal of Urology
: 2014  |  Volume : 30  |  Issue : 2  |  Page : 181--188

Pharmacology of the lower urinary tract

Martin Hennenberg, Christian G Stief, Christian Gratzke 
 Department of Urology, Ludwig-Maximilans University, Munich, Germany

Correspondence Address:
Christian Gratzke
Urologische Klinik, Marchioninistr 15, 81377 München

Pharmacology of the lower urinary tract provides the basis for medical treatment of lower urinary tract symptoms (LUTS). Therapy of LUTS addresses obstructive symptoms (frequently explained by increased prostate smooth muscle tone and prostate enlargement) in patients with benign prostate hyperplasia (BPH) and storage symptoms in patients with overactive bladder (OAB). Targets for medical treatment include G protein-coupled receptors (α1 -adrenoceptors, muscarinic acetylcholine receptors, β3-adrenoceptors) or intracellular enzymes (5α-reductase; phosphodiesterase-5, PDE5). Established therapies of obstructive symptoms aim to induce prostate smooth muscle relaxation by α1 -blockers or PDE5 inhibitors, or to reduce prostate growth and volume with 5α-reductase inhibitors. Available options for treatment of OAB comprise anitmuscarinics, β3 -adrenoceptor agonists, and botulinum toxin A, which improve storage symptoms by inhibition of bladder smooth muscle contraction. With the recent approval of β3 -antagonists, PDE inhibitors, and silodosin for therapy of LUTS, progress from basic research of lower urinary tract pharmacology was translated into new clinical applications. Further targets are in preclinical stages of examination, including modulators of the endocannabinoid system and transient receptor potential (TRP) channels.

How to cite this article:
Hennenberg M, Stief CG, Gratzke C. Pharmacology of the lower urinary tract.Indian J Urol 2014;30:181-188

How to cite this URL:
Hennenberg M, Stief CG, Gratzke C. Pharmacology of the lower urinary tract. Indian J Urol [serial online] 2014 [cited 2020 Aug 14 ];30:181-188
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