|Year : 2017 | Volume
| Issue : 2 | Page : 99-100
Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India
|Date of Web Publication||30-Mar-2017|
Department of Urology, Christian Medical College, Vellore, Tamil Nadu
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Panda A. What's inside. Indian J Urol 2017;33:99-100
| Multiparametric Magnetic Resonance Imaging: Transrectal Ultrasound-guided Fusion Biopsy|| |
Prostate cancer in India presents late and remains an important cause of death in men. Bansal et al. present data regarding the use of multiparametric-magnetic resonance imaging transrectal ultrasound fusion biopsy in an Indian cohort of patients. Prostate cancer in India may have a different presentation compared to the West, and Indian data can help us further refine our management protocols.
| Penile Urethral Strictures|| |
Strictures of the penile urethra are difficult to manage. Skin flaps to grafts have all been used with varying degrees of success. Joshi et al. present a composite two-stage urethroplasty for complex penile strictures without balanitis xerotica obliterans (BXO). The buccal mucosal graft (BMG) was applied in the second stage and immediately tubularized. This is distinct from the commonly performed technique of applying the BMG in the first stage. Despite excluding BXO strictures, the patients included both failed hypospadias repair and other causes of urethral strictures. Residual chordee in the former group will present a challenge, but the concept that immediate tubularization will aid take of the graft due to a moist environment has merit and can improve results.
| Prognosticating and Novel Therapy for Bladder Cancer: the Role of Micro-rnas|| |
Recurrent bladder cancer is hypothesized to be a result of field change in the transitional epithelium of the urinary tract. Markers for progression and invasiveness can help us offer management options that are tailored to the individual patient. Mitash et al. review the role of cellular metabolic regulatory molecules, such as micro-RNA, which can be used as biomarkers to prognosticate or as targeted therapy for bladder cancer.
| An Incontinence Activity Participation Scale for Spinal Cord Injury|| |
Walia and Kaur  present a novel scale to measure the involvement of spinal cord injured (SCI) patients in life situations. Incontinence is a major barrier for increased participation in activities outside their homes. The scale should help urologists quantify the problems of SCI patients and follow up on the success of therapy.
| Extended - Spectrum Beta-lactamase - Producing, Carbapenem-resistant Uropathogens May Be Fosfomycin Sensitive|| |
Carbapenem-resistant pathogens have rapidly spread to almost all hospital settings. They remain perhaps the greatest threat to our attempts to control serious nosocomial infections. Banerjee et al. discuss the role of fosfomycin in the treatment of such isolates. However, the translation of in vitro sensitivity into in vivo success and clinical usefulness of this drug remains to be seen.
| Does the Indication for Partial Nephrectomy Affect the Complication and Outcomes?|| |
Venkatramani et al. reviewed data to see if the preoperative indications for partial nephrectomy (elective, relative, and absolute) affected the perioperative complications and outcome. The results point to fewer complications in the elective arm.
| Can Sterile Water Irrigation Be a Substitute for Single-dose Mitomycin-c After Transurethral Resection of Bladder Tumors?|| |
The use of intravesical mitomycin-C immediately after transurethral resection of bladder tumor is common in an attempt to prevent tumor cell re-implantation and consequent recurrence. In a randomized controlled trial, Bijalwan et al. compared continuous irrigation with sterile water to a single intravesical mitomycin C instillation and detected no significant difference.
| Bladder Cancer: What the Future Holds?|| |
While radical cystectomy remains the primary surgery for muscle invasive bladder cancer, the therapy is multimodal. The treatment of advanced bladder cancer has changed over the years with newer chemotherapeutic agents and molecular subtyping of the cancer. This issue has a symposium on muscle invasive bladder cancer guest edited by Kamat  which discusses the newer trends in therapy.
| Surgical Management of Muscle Invasive Bladder Cancer|| |
Treatment of muscle invasive bladder cancer continues to evolve with ongoing discussions on the use of neoadjuvant chemotherapy, extent of pelvic lymph node dissection, and an attempt on organ preservation. Kukreja and Shah  discuss the advances in its surgical management.
| Bladder Preservation in Selected Cases of Muscle Invasive Cancer|| |
Radical cystectomy is the gold standard for muscle invasive bladder cancer. Wade-Smelser et al. review the role of bladder preservation in selected cases, indications, and oncological outcomes. The quality of life after such therapy is also discussed.
| Systemic Therapy in Bladder Cancer|| |
Neoadjuvant therapy for muscle invasive disease has achieved better survival rates than primary surgery. All patients who may benefit from therapy, however, do not receive it. Pinto  discusses the agents used in neoadjuvant and adjuvant settings in muscle invasive disease. The role of second-line immunotherapy is also discussed.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Bansal S, Gupta NP, Yadav R, Khera R, Ahlawat K, Gautam D, et al
. Multiparametric magnetic resonance imaging-transrectal ultrasound fusion prostate biopsy: A prospective, single centre study. Indian J Urol 2017;33:134-9. [Full text]
Mitash N, Tiwari S, Agnihotri S, Mandhani A. Bladder cancer: Micro RNAs as biomolecules for prognostication and surveillance. Indian J Urol 2017;33:127-3. [Full text]
Joshi PM, Barbagli G, Batra V, Surana S, Hamouda A, Sansalone S, et al
. Composite two-stage urethroplasty for complex penile strictures: A multicenter experience. Indian J Urol 2017;33:155-8. [Full text]
Walia P, Kaur J. Development and validation of incontinence-Activity participation scale (I-APS) for spinal cord injury. Indian J Urol 2017;33159-64.
Banerjee S, Sengupta M, Sarker TK. Fosfomycin susceptibility among multidrug resistant, ESBL producing, and carbapenem resistant uropathogens. Indian J Urol 2017;33:149-54. [Full text]
Venkatramani V, Kumar S, Chandrasingh J, Devasia A, Kekre NS. Perioperative complications and postoperative outcomes of partial nephrectomy for renal cell carcinoma: Does indication matter? Indian J Urol 2017;33:140-3. [Full text]
Bijalwan P, Pooleri GK, Thomas A. comparison of sterile water irrigation vs. intravesical mitomycin C in preventing the recurrence of non-muscle invasive bladder cancer after transurethral resection. Indian J Urol 2017;33:144-8. [Full text]
Kamat A. Bladder Cancer: 2017 and beyond. Indian J Urol 2017;33:104-5. [Full text]
Kukreja JB, Shah JB. Advances in surgical management of muscle invasive bladder cancer. Indian J Urol 2017;33:106-10. [Full text]
Smelser WW, Austenfeld MA, Holzbeierlein JM, Lee EK. Where are we with bladder preservation for muscle-invasive bladder cancer in 2016? Indian J Urol 2017;33:111-7. [Full text]
Pinto IG. Systemic therapy in bladder cancer. Indian J Urol 2017;33:118-26. [Full text]