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ORIGINAL ARTICLE
Year : 2015  |  Volume : 31  |  Issue : 2  |  Page : 116-119

Does varicocelectomy affect DNA fragmentation in infertile patients?


1 Department of Urology, Ankara University, School of Medicine, Antalya, Turkey
2 Ankara Training and Research Hospital, Clinic of Urology, Antalya, Turkey
3 Department of Biostatistics and Medical Informatics, Akdeniz University, School of Medicine, Antalya, Turkey

Correspondence Address:
Dr. Onur Telli
Department of Urology, Ankara University, School of Medicine, Sihhiye/Ankara
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.152811

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Introduction: The aims of this study were to investigate the effect of varicocelectomy on DNA fragmentation index and semen parameters in infertile patients before and after surgical repair of varicocele. Materials and Methods: In this prospective study, 72 men with at least 1-year history of infertility, varicocele and oligospermia were examined. Varicocele sperm samples were classified as normal or pathological according to the 2010 World Health Organization guidelines. The acridine orange test was used to assess the DNA fragmentation index (DFI) preoperatively and postoperatively. Results: DFI decreased significantly after varicocelectomy from 34.5% to 28.2% (P = 0.024). In addition all sperm parameters such as mean sperm count, sperm concentration, progressive motility and sperm morphology significantly increased from 19.5 × 10 6 to 30.7 × 10 6 , 5.4 × 10 6 /ml to 14.3 × 10 6 /ml, and 19.9% to 31.2% (P < 0.001) and 2.6% to 3.1% (P = 0.017). The study was limited by the loss to follow-up of some patients and unrecorded pregnancy outcome due to short follow-up. Conclusion: Varicocele causes DNA-damage in spermatozoa. We suggest that varicocelectomy improves sperm parameters and decreases DFI.


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