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SYMPOSIUM
Year : 2014  |  Volume : 30  |  Issue : 4  |  Page : 423-428

Significance and management of positive surgical margins at the time of radical prostatectomy


1 Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA
2 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, N, USA

Correspondence Address:
Jonathan L. Silberstein
Chief Section of Urologic Oncology, Tulane University School of Medicine, 1430 Tulane Ave, SL-42 New Orleans, LA 70112
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.134240

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Positive surgical margins (PSM) at the time of radical prostatectomy (RP) result in an increased risk of biochemical recurrence (BCR) and secondary treatment. We review current literature with a focus on stratifying the characteristics of the PSM that may define its significance, the impact of modern imaging and surgical approaches in avoidance of PSM, and management strategies when PSM do occur. We performed a review of the available literature to identify factors associated with PSM and their management. PSM have been repeatedly demonstrated to be associated with an increased risk of BCR following RP. The specific characteristics (size, number, location, Gleason score at the margin) of the PSM may influence the risk of recurrence. Novel imaging and surgical approaches are being investigated and may allow for reductions of PSM in the future. The use of adjuvant treatment for a PSM remains controversial and should be decided on an individual basis after a discussion about the risks and benefits. The goal of RP is complete resection of the tumor. PSM are associated with increased risk of BCR and secondary treatments. Of the risk factors associated with BCR after RP, a PSM is directly influenced by surgical technique.


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