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ORIGINAL ARTICLE
Year : 2014  |  Volume : 30  |  Issue : 4  |  Page : 374-377
 

Continence outcomes following robotic radical prostatectomy: Our experience from 150 consecutive patients


Department of Urology, Institute of Kidney and Urology, Medanta-The Medicity, Sector 38, Gurgaon, Haryana, India

Date of Web Publication1-Oct-2014

Correspondence Address:
Rajiv Yadav
Institute of Kidney and Urology, Medanta-The Medicity, Sector 38, Gurgaon, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.139575

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   Abstract 

Introduction: Urinary continence is an important outcome parameter after robot assisted radical prostatectomy (RARP). We evaluated the continence outcomes following RARP using a double-layered urethrovesical reconstruction.
Materials and Methods: One hundred fifty consecutive patients undergoing RARP and double-layered urethrovesical reconstruction were prospectively studied for preoperative, intraoperative and post operative parameters. Key points followed during surgery were: Minimal dissection of sphincteric complex, preservation of puboprostatic ligament, selective ligation of deep venous complex and both posterior and anterior reconstruction using the Von Velthoven stitch. Intraoperative bladder fill test was done at the end of anastomosis to rule out urine leak. Check cystogram was done prior to catheter removal in the outpatient department. Patients were subsequently followed at regular intervals regarding the status of urinary continence. All patients irrespective of adjuvant therapy were included in the analysis.
Results: The mean age was 64 years (standard deviation ± 6.88), and mean serum PSA was 20.2 ng/ml. The mean BMI was 25.6 (SD: ±3.84). The mean prostate weight was 44.09 gm (range 18-103 gm, SD: ±15.59). Median days to catheter removal after surgery was 7 (range 4-14 days) days. Cystographically determined urinary leaks were seen in two patients. Urine leak was managed by delaying catheter removal for 1 week. Minimum 6 month follow up was available in 126 patients. 'No pad' status at 1 week, 1 month, 3 months, 6 months and 1 year was 15.1%, 54.9%, 78%, 90.5% and 94.1%, respectively.
Conclusion: Excellent continence outcomes are observed in patients undergoing double-layered urethrovesical reconstruction.


Keywords: Prostate cancer, Robotic surgery, Continence, Robotic prostatectomy, double-layered urethrovesical reconstruction


How to cite this article:
Gupta NP, Yadav R, Akpo EE. Continence outcomes following robotic radical prostatectomy: Our experience from 150 consecutive patients. Indian J Urol 2014;30:374-7

How to cite this URL:
Gupta NP, Yadav R, Akpo EE. Continence outcomes following robotic radical prostatectomy: Our experience from 150 consecutive patients. Indian J Urol [serial online] 2014 [cited 2019 Sep 17];30:374-7. Available from: http://www.indianjurol.com/text.asp?2014/30/4/374/139575



   Introduction Top


Prostate cancer is the most common cancer diagnosed in men and the second most common cause of death from cancer in industrialized countries. In India, the incidence of prostate cancer is second among all the cancers in men and a rising mean annual percentage change of 0.14-8.6. [1] More Indian men with prostate cancer are being diagnosed with a localized prostate cancer as a result of awareness, screening and improved diagnostic armamentaria. Robot-assisted radical prostatectomy (RARP) has become the most preferred surgical modality for the treatment of localized prostate cancer. [2] However, postoperative urinary incontinence remains one of the most bothersome complications with reported incidence of 7-40%. [3] Significant improvement in continence results following RARP has been reported in recent series. Several technical modifications proposed and put into practice over the years have contributed to improved overall continence rates as well as faster return to continence. The underlying basic concept of all these techniques is to maintain normal anatomical and functional structures in the pelvis or to restore the anatomy to the best possible extent. Some of the surgical modifications to improve early continence outcomes described in the literature include (but not limited to): Sparing of the puboprostatic ligaments, [4],[5],[6] bladder neck preservation, [7],[8],[9] posterior reconstruction of Denonvilliers' musculofascial plate, [10],[11],[12],[13] restoration of the puboprostatic collar, [14] and complete reconstruction of the periurethral supportive tissues. [15],[16] However, the technique of RARP is a evolutionary continuum and improved continence result is the additive effect of all the individual steps. We performed double-layered urethrovesical anastomosis using two, monofilament Van Velthoven stitches in 150 consecutive patients. The aim of this study is to evaluate continence outcomes in our patients.


   Materials and methods Top


Between April 2010 and August 2013, clinical and pathologic data were prospectively recorded of all cases who underwent RARP and total anatomical reconstruction. All the patients underwent RARP through transperitoneal approach using 4 arm da Vinci surgical system. Key points followed during prostatic dissection were: Minimal dissection of sphincteric complex with preservation of puboprostatic ligament, nerve sparing surgery whenever indicated, selective ligation of deep venous complex, preservation of maximal urethral length. Reconstruction consisted of double-layered anastomosis done by reapproximation of Denonvillier's fascia and posterior rhabdosphincter, as well as reapproximation of the puboprostatic ligaments to the anterior pubovesical collar. [15] Two, 3-0 double-armed monofilament sutures were used. The first suture was started at 5'0 clock position for posterior reconstruction and creation of posterior plate by approximating posterior rhabdosphincter (on urethral side) to posterior layer of Denonvilliers fascia (on bladder side). Using the second suture, the urethrovesical anastomosis (inner layer) was then completed all around by performing mucosa to mucosa approximation. Finally, the outer layer was completed by approximating the puboprostatic ligament to the anterior pubovesical collar. Bladder fill test with 120 ml saline was done after completion of anastomosis. Any significant leak noted during bladder fill test was repaired by interrupted sutures. Indwelling Foley catheter was kept in all the cases. Check cystogram was done prior to catheter removal in the outpatient department on Day 7 of surgery. Catheter removal was done if no leak was noted on cystogram. Patients were instructed to perform 'Kegel exercises' starting 3 days after catheter removal.

Follow up: Demographic, operative and follow-up data were retrieved from the electronic database in the hospital's electronic medical records. Patients were followed at regular intervals (at 1 week, 4 weeks, 3 months, 6 months and 12 months post catheter removal) in the outpatient clinic or contacted on phone/email regarding the status of urinary continence and number of pad used. Continence was defined as using 'no pad' or just a security liner. All patients irrespective of adjuvant therapy were included in the analysis.

Data collection and follow-up correspondence were conducted in accordance with the hospital's ethical guidelines.


   Results Top


From April 2010 to August 2013, 153 patients underwent RALP by the two surgeons in a single institution. Of these patients three international patients were excluded from analysis due to non-availability of follow up data. Clinical and pathologic characteristics of the patients are shown in [Table 1]. The mean age was 64 years (standard deviation ± 6.88), and the mean serum PSA was 20.2 ng/ml. The mean BMI was 25.6 (SD: ±3.84), and the mean prostate weight (on final specimen) was 44.09 gm (range 18-103 gm, SD: ±15.59). Median postoperative hospital stay was 3 days. Median days to catheter removal after surgery were 7 (range 4-14 days) days. Cystographically determined urinary leaks were seen in two patients. Urine leak was managed by delaying the catheter removal for another 1 week. At least 6 month follow up was available in 126 patients. 'No pad' status at 0 week, 1 month, 3 months, 6 months and 1 year was 15.1%, 54.9%, 78%, 90.5% and 94.1%, respectively [Table 2] and [Figure 1]. No significant correlation was found on multivariate logistic regression analysis in rate of continence and prostate size, nerve sparing status or age of patient. However, trend toward early continence was noted in younger patients.
Table 1: Clinical and pathologic characteristics of the study population

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Table 2: Status of urinary continence on follow up

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Figure 1: Graph showing percentage of patients achieving continence during follow up

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   Discussion Top


The focus of treatment for localized prostate cancer is not only better cancer control but also to maintain the quality of life. Postoperative urinary incontinence (UI) following radical prostatectomy (RP) remains a bothersome issue. Large contemporary series have reported continence rates ranging from 84% to 97% at 1 year. [17] Thus, even though most of the patients regain their continence at 1 year, patients do suffer the psychological trauma of UI for varying period in the post operative phase. Over the years, several technical modifications and collective experience of open and conventional laparoscopic RP have contributed to the improvement seen in early and overall continence rates. Both posterior [10] and anterior reconstructions [14] have been independently shown to be helpful in improving early continence. In our patient we have taken advantage of both the approaches and noted that approximately 55% of our patients are fully continent just after 1 month of surgery. By 6 months 90% of our cohort regained continence. The results are comparable to other large series who have taken the similar reconstructive approach. [17],[18],[19],[20]

Technical modifications allowing rapid return of urinary continence after surgery relies on maintaining anatomical and functional structures in the pelvis to the greatest possible extent. [21] The major components of the pelvic supporting system in males are Denonvilliers' fascia, puboprostatic ligament, endopelvic fascia, levator ani muscle and arcus tendineus fascia pelvis. Thus, not only preservation, but also reconstruction of these structures play a potential role in improving the recovery of urinary incontinence. [21] Based on this concept, three steps have been advocated intra-operatively to preserve post-prostatectomy continence: (1) Preservation of bladder neck, nerves, puboprostatic ligament, pubovesical complex and urethral length; (2) reconstruction of the rhabdosphincter posteriorly, anterior retropubic suspension, reattachment of the arcus tendineus to the bladder neck and total reconstruction of the vesicourethral junction and (3) reinforcement of the bladder neck by plication and bladder neck sling suspension. [21]

In our patients we made no special attempt to preserve the bladder neck as the majority of cases were high risk with large volume of tumor. However, we did attempt to preserve the puboprostatic ligament and preserve maximal urethral length. During reconstruction, posterior reconstruction helps in restoring the anatomic and functional length of the rhabdosphincter and by providing posterior support to the urethra. [10] Although the delayed continence rate achieved at 1 year may be the same in patients with or without posterior reconstruction, several authors have reported achievement of faster continence (early continence) with this method. [10],[11],[12],[15] We observed that more than 90% of our patients achieve continence by 6 months. Another potential advantage is that along with anterior reconstruction, it also takes away the tension from the actual urethrovesical anastomosis and makes it easier to perform (especially in difficult cases). Sammon et al. [20] have also reported significantly lower rates of cystographically determined anastomotic leak rate with double-layer anastomosis (none versus 10% when compared to single layered anastomosis). We have also noted a very low leak rate (<1%) in our patients.

We realize that our study has certain shortcomings, chiefly being the non-objective way of defining continence leak based upon usage of number of pads and not the urine leakage weight. However, the effect on results is minimal as our definition of continence was use of either 'no pad' or just a 'security liner'. No health-related quality of life score assessment was done during the study which could have added another parameter to the analysis. Also, all our patients underwent double-layered urethrovesical anastomosis therefore it is not possible for us to gauge the difference in outcomes between single-layered versus double-layered anastomosis (if at all).

In conclusion, double-layered urethrovesical anastomosis combines the benefits of both posterior and anterior reconstructions and provides excellent continence outcomes.

 
   References Top

1.Raina V, Tyagi BB, Manoharan N, Rath GK. Cancer incidence and mortality in Delhi UT Urban 2006. New Delhi: Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences; 2006.  Back to cited text no. 1
    
2.Ali A, Nguyen DP, Tewari A. Robot assisted laparoscopic prostatectomy in 2013. Minerva Chir 2013;68:499-512.  Back to cited text no. 2
    
3.Ficarra V, Novara G, Artibani W, Cestari A, Galfano A, Graefen M, et al. Retropubic, laparoscopic, and robot-assisted radical prostatectomy: A systematic review and cumulative analysis of comparative studies. Eur Urol 2009;55:1037-63.  Back to cited text no. 3
    
4.Poore RE, McCullough DL, Jarow JP.Puboprostatic ligament sparing improves urinary continence after radical retropubic prostatectomy. Urology 1998;51:67-72.  Back to cited text no. 4
    
5.Jarow JP. Puboprostatic ligament sparing radical retropubic prostatectomy. Semin Urol Oncol 2000;18:28-32.  Back to cited text no. 5
[PUBMED]    
6.Stolzenburg JU, Liatsikos EN, Rabenalt R, Do M, Sakelaropoulos G, Horn LC, et al. Nerve sparing endoscopic extraperitoneal radical prostatectomy-effect of puboprostatic ligament preservation on early continence and positive margins. Eur Urol 2006;49:103-12.  Back to cited text no. 6
    
7.Presti JC, Jr., Schmidt RA, Narayan PA, Carroll PR, Tanagho EA. Pathophysiology of urinary incontinence after radical prostatectomy. J Urol 1990;143:975-8.  Back to cited text no. 7
    
8.Deliveliotis C, Protogerou V, Alargof E, Varkarakis J. Radical prostatectomy: Bladder neck preservation and puboprostatic ligament sparing-effects on continence and positive margins. Urology 2002;60:855-8.  Back to cited text no. 8
    
9.Freire MP, Weinberg AC, Lei Y, Soukup JR, Lipsitz SR, Prasad SM, et al. Anatomic bladder neck preservation during robotic-assisted laparoscopic radical prostatectomy: Description of technique and outcomes. Eur Urol 2009;56:972-80.  Back to cited text no. 9
    
10.Rocco F, Carmignani L, Acquati P, Gadda F, Dell'Orto P, Rocco B, et al. Restoration of posterior aspect of rhabdosphincter shortens continence time after radical retropubic prostatectomy. J Urol 2006;175:2201-6.  Back to cited text no. 10
    
11.Rocco F, Carmignani L, Acquati P, Gadda F, Dell'Orto P, Rocco B, et al. Early continence recovery after open radical prostatectomy with restoration of the posterior aspect of the rhabdosphincter. Eur Urol 2007;52:376-83.  Back to cited text no. 11
    
12.Nguyen MM, Kamoi K, Stein RJ, Aron M, Hafron JM, Turna B, et al. Early continence outcomes of posterior musculofascial plate reconstruction during robotic and laparoscopic prostatectomy. BJU Int 2008;101:1135-9.  Back to cited text no. 12
    
13.Stein RJ. The case for posterior musculofascial plate reconstruction in robotic prostatectomy. Urology 2009;74:489-91.  Back to cited text no. 13
[PUBMED]    
14.Tewari AK, Bigelow K, Rao S, Takenaka A, El-Tabi N, Te A, et al. Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar: A novel modification to achieve early urinary continence in men undergoing robotic prostatectomy. Urology 2007;69:726-31.  Back to cited text no. 14
    
15.Menon M, Muhletaler F, Campos M, Peabody JO. Assessment of early continence after reconstruction of the periprostatic tissues in patients undergoing computer assisted (robotic) prostatectomy: Results of a 2 group parallel randomized controlled trial. J Urol 2008;180:1018-23.  Back to cited text no. 15
    
16.Tewari A, Jhaveri J, Rao S, Yadav R, Bartsch G, Te A, et al. Total reconstruction of the vesico-urethral junction. BJU Int 2008;101:871-7.  Back to cited text no. 16
    
17.Ficarra V, Novara G, Rosen RC, Artibani W, Carroll PR, Costello A, et al. Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. Eur Urol; 62:405-17.  Back to cited text no. 17
    
18.Ficarra V, Novara G, Fracalanza S, D'Elia C, Secco S, Iafrate M, et al. A prospective, non-randomized trial comparing robot-assisted laparoscopic and retropubic radical prostatectomy in one European institution. BJU Int 2009;104:534-9.  Back to cited text no. 18
    
19.Koliakos N, Mottrie A, Buffi N, De Naeyer G, Willemsen P, Fonteyne E. Posterior and anterior fixation of the urethra during robotic prostatectomy improves early continence rates.Scand J Urol Nephrol 2010;44:5-10.  Back to cited text no. 19
    
20.Sammon JD, Muhletaler F, Peabody JO, Diaz-Insua M, Satyanaryana R, Menon M. Long-term functional urinary outcomes comparing single- vs double-layer urethrovesical anastomosis: Two-year follow-up of a two-group parallel randomized controlled trial. Urology 2010;76:1102-7.  Back to cited text no. 20
    
21.Kojima Y, Takahashi N, Haga N, Nomiya M, Yanagida T, Ishibashi K, et al. Urinary incontinence after robot-assisted radical prostatectomy: Pathophysiology and intraoperative techniques to improve surgical outcome. Int J Urol 2013;20:1052-63.  Back to cited text no. 21
    


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