|Year : 2014 | Volume
| Issue : 3 | Page : 318-325
Teresa L Danforth, Monish Aron, David A Ginsberg
Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
|Date of Web Publication||1-Jul-2014|
Teresa L Danforth
Department of Urology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, California 90089-9178
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Pelvic organ prolapse (POP) is a prevalent condition with 1 in 9 women seeking surgical treatment by the age of 80 years. Goals of treatment are relief and prevention of symptoms, and restoration of pelvic floor support. The gold standard for surgical treatment of POP has been abdominal sacrocolpopexy (ASC). However, emerging technologies have allowed for more minimally invasive approach including the use of laparoscopic assisted sacrocolpopexy and robotic assisted sacrocolpopexy (RASC). We performed a PubMed literature search for sacrocolpopexy, "robotic sacrocolpopexy" and "RASC" and reviewed all retrospective, prospective and randomized controlled trials. The techniques, objective and subjective outcomes and complications are discussed. The most frequent technique involves a polypropylene Y mesh attached to the anterior and posterior walls of the vagina with the single arm attached to the sacrum. Multiple concomitant procedures have been described including hysterectomy, anti-incontinence procedures and concomitant vaginal prolapse repairs. There are few studies comparing RASC to ASC, with the longest follow-up data showing no difference in subjective and objective outcomes. Anatomic success rates have been reported at 79-100% with up to 9% of patients requiring successive surgery for recurrence. Subjective success is poorly defi ned, but has been reported at 88-97%. Most common complications are urinary retention, urinary tract infection, bladder injury and vaginal mucosal injury. Mesh exposure is reported in up to 10% of patients. RASC allows for a minimally invasive approach to treatment of POP with comparable outcomes and low complication rates.
Keywords: Pelvic organ prolapse, robotic, sacrocolpopexy
|How to cite this article:|
Danforth TL, Aron M, Ginsberg DA. Robotic sacrocolpopexy. Indian J Urol 2014;30:318-25
| Introduction|| |
Pelvic organ prolapse (POP) is a common condition among aging women with one in nine women estimated to undergo surgical repair by the age of 80 years and one-third of these women requiring a subsequent surgery for recurrence or treatment of new symptoms like stress urinary incontinence.  There are multiple approaches, surgical and non-surgical to treat POP. The goals of treatment should be aimed at relief of symptoms, restoring pelvic floor support, prevention of new symptoms and management of concomitant urinary, bowel and sexual dysfunction.
| Anatomy and indications|| |
The pelvic floor is divided into three levels of support, which include structures such as bone, muscles, ligaments and fascia.  The first level of support is at the apex of the vagina where the paracolpium suspends the uterus [Figure 1]. Level II support is along the lateral vagina and consists of the arcus tendineus fascia pelvis. Level III support is the most distal where the vagina fuses to the urogenital diaphragm. Loss of Level I or apical support is what generally leads to POP, which can be in combination with the loss of Level II support. Loss of Level III support is what leads to urethral hypermobility.
The most common symptom associated with POP is a vaginal bulge in 94-100% of patients.  Other symptoms include pelvic pain or pressure, back pain, dyspareunia, urgency, frequency, incontinence and bowel symptoms. It is important to take a good history from patients and fully examine for prolapse in all compartments (anterior, apical and posterior) as well as examination for occult stress incontinence. This will then allow the surgeon to appropriately plan for concomitant procedures and counsel patient as to their expectations.
|Figure 1: Vaginal and visceral supportive structures as defi ned by DeLancey Level I support spreads vertically and posteriorly via the paracolpium suspending the uterus. Level II support supplies the mid-vagina to the arcus tendineus fascia pelvis. Level III support fuses directly into the urogenital diaphragm (adapted from DeLancey Anatomic aspects of vaginal eversion after hysterectomy)|
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POP can be staged or graded using the Baden-Walker Classification or the POP-quantification (POP-Q) classification.  POP-Q is defined as follows:
- Stage O: No prolapse
- Stage I: Distal prolapse > 1 cm proximal to hymen
- Stage II:Distal prolapse within 1 cm of hymen, either proximal or distal
- Stage III: Distal prolapse >1 cm below hymen without complete eversion
- Stage IV: Complete vaginal eversion.
POP-Q uses reference points within the vagina to better characterize the location and level of prolapse [Figure 2]. 
|Figure 2: Pelvic organ prolapse-quantifi cation adapted from Bump et al. Six sites (points Aa, Ba, C, D, Bp, Ap) as well as the genital hiatus, total vaginal length and perineal body are all used for quantifi cation of POP (adapted from Bump et al., The standardization of terminology of female POP and pelvic floor dysfunction)|
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| Treatment options|| |
The first line treatment for POP is observation. Active treatment is only necessary when patient is bothered enough by her symptoms to desire therapy. A pessary is a non-surgical treatment option for patients wishing to avoid any surgery or for those who wish to see if restoration of support relieves their symptoms prior to considering surgical repair. Surgical options are focused on obliterative versus restorative techniques. The obliterative option is a colpocleisis and reserved for patients who do not wish to maintain any sexual function or want to avoid a more complex repair. Restorative options include transvaginal primary repair with or without mesh, abdominal sacrocolpopexy (ASC), laparoscopic assisted sacrocolpopexy (LASC) and robotic assisted sacrocolpopexy (RASC). 
Transvaginal repairs can be performed primarily or with the use of mesh. The vaginal approach uses the sacrospinous ligaments, uterosacral ligaments or iliococcygeus muscles to regain support of the apex. McCall culdoplasty, first described in 1957, allows for correction of enterocele as well as providing apical support at the level of the uterosacral ligaments with permanent sutures.  Sacrospinous ligament suspension can be performed with or without mesh, unilaterally or bilaterally. The apex of the vagina is suspended to the sacrospinous ligament, medially to the ischial spine. Various instruments have been developed to aid in the passage of suture through the sacrospinous ligament, including the Deschamps ligature, Miya hook, Capio™ suture capturing device or the Nichols-Veronikis ligature carrier.
It is important to address all compartments at the time of transvaginal repair. Often when suspending the apex, there is involvement of the anterior and posterior compartments. These compartments often should be addressed at the same time of apical repair.
The gold standard for the treatment of apical POP has traditionally been ASC. The initial reports of ASC were published by Lane in 1962 where he described using graft material to suspend the vagina from the sacrum.  The procedure has been revised to include the attachment of the graft along the full vaginal wall to decrease detachment from the apex of the vagina.  Mesh erosions have promoted reduction in the amount of mesh used. The polypropylene Y mesh is the most common configuration now used, allowing for differential tension anteriorly and posteriorly. ASC has been used to treat vaginal vault prolapse as well as perineal descent by extending the posterior arm of the mesh to the level of the perineal body. 
Concomitant procedures have become very common during ASC. Culdoplasty is often used to prevent enterocele and there are reports of concomitant posterior repair by those who do not think they can adequately repair the defect abdominally.  Concurrent hysterectomy has been performed with the known increased risk of mesh extrusion at the vaginal cuff. Supracervical hysterectomy can be performed to decrease this risk. The use of concomitant anti-incontinence procedures is discussed later.
Emerging technologies have allowed for more minimally invasive techniques including laparoscopic and RASC. In this article we will focus on reviewing the literature of treatment of POP with RASC, comparing it to outcomes of ASC and transvaginal repair.
| Materials and Methods|| |
A PubMed literature search was performed using the words "sacrocolpopexy" "robotic sacrocolpopexy" "RASC". Retrospective, prospective and randomized controlled trials in English were reviewed. Meta-analysis criteria could not be applied, as the studies were heterogeneous in their outcomes reporting and length of follow-up. All studies were included regardless of the number of patients.
The use of the daVinci robot in urogynecologic surgery has multiple advantages over laparoscopy since its approval in 2005. This system allows for multiple degrees of freedom to improve manual dexterity and essentially eliminates tremors. It also allows for better visualization with a three-dimensional imaging system. All of these factors allow for a faster learning curve for those already doing laparoscopy and desiring to switch to robotics and for those in training. Multiple studies have looked at the learning curve for RASC. ,,,, Akl et al. showed a significant decrease in operative time by 25% after the first ten robotic cases.  Geller et al. looked at specific steps to the procedure and found that after the first 20 cases, there was significant improvements in times to completion of multiple steps of the procedure. 
There are multiple variations to the technique of RASC described, but the general principals remain the same. ,,,,,,,,,,,,,,, The patient is placed in the dorsal lithotomy position and pneumoperitoneum is obtained. A 12 mm camera port is placed periumbilically followed by two to three 8 mm robotic ports and one to two assistant ports. The configuration has been described most commonly as a "W" configuration ,, with two robotic ports lateral to the rectus but inferior to the camera port, one 12 mm assistant port subcostally on the right and one 8 mm robotic port subcostally on the left. Regardless of the port configuration it is critical to keep at least 8-10 cm between ports to prevent collision of the robotic arms. After the ports are placed, patient is placed in steep Trendelenburg position and the robot is docked between the legs at the foot of the bed.
The colon can be reflected laterally using a bowel retraction suture on the left abdominal wall as described by Burgess and Elliott  The sacral promontory is then exposed with care taken to avoid the middle sacral artery. A vaginal sizer is used to provide counter-traction on the vagina while dissecting the peritoneum off the posterior vaginal wall and peritoneum and bladder off of the anterior vaginal wall. It is important to carry the anterior dissection as distally as possible to allow for mesh placement to provide maximal support.
Different types of mesh and mesh configurations have been used including Marlex, silastic and polyester. Polypropylene Y mesh is the most common type of mesh used. The mesh is brought in through the assistant port and the short arms of the Y mesh are sutured to the anterior and/or posterior vaginal wall with a non-absorbable suture such as Gor-Tex® or a long lasting absorbable suture.
The peritoneal incision can be carried out to the level of the sacral promontory or the mesh can be tunneled underneath the peritoneum to allow for less area of potential mesh exposure. The long arm of the Y mesh is then attached to the sacral promontory with non-absorbable suture. Most of the authors describe closure of the peritoneum to avoid exposure of mesh to the bowel. ,,[17-23],,,
Concomitant procedures have been described in many series of RASC and range from 0% to 87.5%. ,,, Few series of RASC purposely excluded patients with concomitant surgeries to focus on the outcomes of RASC alone. ,, When included, these procedures are generally divided into three categories: Hysterectomy, anti-incontinence procedures and vaginal prolapse repairs.
Hysterectomy is the most common procedure associated with RASC with up to 92.5% of patients undergoing concomitant hysterectomy.  Many times the hysterectomy is supracervical to avoid exposure of the mesh at the vaginal cuff. ,,,,,, On the contrary, Mourik et al. described the technique of uterine sparing RASC in a series 40 patients to emphasize that for those wishing to keep their uterus, success rates remain high. 
Following hysterectomy, anti-incontinence procedures are the next most common concomitant procedure with RASC. The biggest challenge is determining, which patients will need an anti-incontinence procedure if they do not complain of baseline stress urinary incontinence (SUI). Multiple methods have been used to reduce prolapse in attempts to adequately predict the chance of developing de novo SUI; however, none of these methods have been validated. Brubaker et al. described the use of prophylactic Burch procedures during an ASC and its improvement in SUI rates at 2 years using data from the CARE trial. This advantage was noted both for patients with and without evidence of occult SUI during the pre-operative evaluation.  No such trials have been performed with RASC and most series do not report their indication for anti-incontinence procedures- i.e. prophylactic versus symptomatic versus occult SUI. Anti-incontinence procedures described include Burch, mid-urethral prolene tape slings (trans-obturator and retropubic) and autologous fascial slings. Mid-urethral slings are the most common procedure and are performed in up to 70% of patients at the time of RASC.  Porta et al. recently retrospectively reviewed 152 patients who underwent ASC with a concomitant bladder neck sling, retropubic mid-urethral sling or a transobturator sling and found no significant difference in outcome in patients with overt or occult SUI.  There is no data at this point to help surgeons decide, which (if any) incontinence procedure should be performed at the time of RASC.
A few studies report the use of concomitant transvaginal prolapse repair at the time of RASC. Matthews et al. describe assessment of patient's vault immediately after the robotic repair is performed to evaluate if there is any significant persistent distal defects or need to reapproximate the genital hiatus.  When indicated, the most common concomitant vaginal prolapse repair procedure is a posterior repair, with or without perineorrhaphy in 26% of patients followed by anterior repairs in 8.7% of patients. , At this point, concomitant vaginal prolapse repair is generally left up to the surgeon and patient preference.
| Outcomes|| |
When examining the outcomes for prolapse surgery; it is important to differentiate anatomical (i.e. objective outcomes) and subjective outcomes. Anatomic outcomes are generally reported using the Baden-Walker scale or POP-Q with the definition of a successful repair defined as Grade 0-1 or Stage 0-1 prolapse at the time of follow-up. Many times the definition of a successful outcome is not defined. Subjective success is even less well-defined than anatomic success. Multiple series have used validated questionnaires to assess patient's symptoms including Pelvic Floor Distress Inventory-20, POP Incontinence Sexual Questionnaire-12, Pelvic Floor Impact Questionnaire-7, Urinary Distress Inventory-6, IIQ-7, EuroQoL questionnaire-5 Dimensions and the Shona Symptom Questionnaire-8. ,,,,,[33-36] Other series simply define subjective success as resolution of prolapse symptoms, which could include bladder, bowel and sexual symptoms. ,,,,
Transvaginal repair in sexually active women is usually performed with native tissue, which most often includes the sacrospinous fixation (SSF) and uterosacral suspension. Due to the increasing concerns over the use of transvaginal mesh, transvaginal repair with mesh has fallen out of favor and generally reserved for non-sexually active patients. A Cochrane review of surgical treatments for POP revealed that treatment of the anterior compartment with native tissue has a higher risk of recurrence than with the use of mesh with a relative risk (RR:2.0).  Compared with SSF, ASC has a lower rate of recurrence (RR:0.23) as well as lower rates of dyspareunia (RR:0.39); however, there was no significant difference in reoperation rates between ASC and transvaginal repair.
Maher et al. did a prospective randomized trial of 95 women who underwent ASC or vaginal sacrospinous colpopexy (without mesh) looking at 2 years outcomes.  Results revealed that subjective success (as defined by no symptoms of prolapse) were similar 94% versus 91% respectively. Objective success defined as no vaginal prolapse beyond the halfway point of the vagina during a Valsalva maneuver, were not significant at 76% and 69%, respectively. Another comparative trial by Lo and Wang looked at 138 patients also did not show a difference in objective outcomes.  This is compared with a prospective randomized trial by Benson et al. who found that patients who underwent ASC had higher optimal results defined as symptom free and no prolapse beyond the hymen.  There are no RCT of RASC compared to transvaginal repair.
The anatomic success rates of ASC, as defined by lack of apical prolapse, has been reported ranging from 78% to 100% with follow-up ranging from 6 months to 3 years.  If one defines success as no apical prolapse, the rates range from 58% to 100%. It is important to understand that these rates are specifically looking at apical prolapse and not the entire vaginal vault. Some surgeons do not address the anterior and posterior compartments at the time of ASC, thus these compartments could potentially have residual prolapse. Anatomic success rates based on patient satisfaction are much more difficult to assess due to inconsistent methods of reporting. The most recent data published by Nygaard et al. reported on the long-term outcomes of ASC from the CARE trial.  After a median of 7 years of follow-up, the probability of anatomic failure was 0.22-0.27 and the probability of symptomatic failure was 0.24-0.29.
There is limited data on post-operative bowel function after ASC as many times it is not reported and when reported the data is inconsistent. Cundiff et al. report when attaching mesh down to the level of the perineal body, about 67% of women had relief of bowel symptoms.  Others have shown increased rates of constipation post-operatively from 29% to 52%  as well as de novo constipation ranging from 16% to 26%. , The data on sexual function is also limited and inconsistent with some showing improvement and some showing worsening of symptoms. , This data is difficult to assess as there are very few patients in these studies.
There are 18 series that describe anatomical outcomes for RASC [Table 1]. Follow-up is anywhere from 6 weeks to 44.2 months. A few series defined anatomic success on POPQ or Baden-Walker; however, criterion of success were poorly defined in many of these papers. ,,,,,,, Success rates have been reported at anywhere from 79% to 100%. 2-10% of patients require a concomitant surgery for recurrent prolapse, which can occur anteriorly, apically or posteriorly. , Furthermore, 1-9% of patients subsequently required an additional procedure for recurrence of POP. ,,,,,,,,,
Subjective success and patient satisfaction has been reported to a range between 88% and 97%. It is difficult to compare subjective outcomes with such variability in the use of validated outcomes measures.
There are few studies comparing outcomes of RASC to the gold standard ASC. Geller et al. reported the longest comparative outcomes data on RASC versus ASC at 44 months.  There was no difference in subjective or objective outcomes in these patients. Siddiqui looked at data from the CARE trial and compared these patients with RASC at 1 year and found no difference in symptomatic or anatomic outcomes. 
In 2011, Paraiso et al. published the only randomized-controlled trial comparing RASC to LASC. They compared 38 patients who underwent LASC to 40 patients who underwent RASC and found that RASC had longer operative times and increased need for pain medication post-operatively compared to LASC.  The two groups did not differ in terms of functional outcomes at 1 year. In contrast, Awad et al. retrospectively compared RASC to LASC and found that RASC had no difference in operative time or adverse events and less EBL and shorter hospital stay.  In addition, Seror prospectively evaluated these two approaches to sacrocolpopexy and reported less EBL and similar operative time in RASC compared with LASC with no difference in anatomic outcomes at 16 months. 
| Complications|| |
Complications can be divided into perioperative complications and long-term complications. Most of the noted complications can occur with transvaginal repair, ASC or RASC and are not specific to technique.
One unique complication to any minimally invasive surgery is the need to convert to an open procedure, which has been shown to be 1-5%. ,,,,,, Interestingly, Paraiso et al. reported two cases that were converted to LASC due to robot malfunction. 
Most common perioperative complications for RASC are listed in [Table 2]. The most common reported complication was post-operative urinary retention in Bedaiwy et al. series of 41 patients where 15 patients (36%) had urinary retention post-operatively.  Of note 66% of these patients underwent a concomitant sling. Other common complications include urinary tract infection (UTI) in 2-14% ],,,,, vaginal mucosal injury in 1-14%, ,, intraoperative bladder injury in 1-10% ,,,,,,, and port site infection in 2-10%. ,,,,, Kramer et al. and Benson et al. describe bowel obstructions occurring due to small bowel migrating behind the mesh. , This prompted a change in their technique to reperitonealize the mesh. Cardio-pulmonary complications have also been described including pulmonary edema, pulmonary embolization, myocardial infarction, arrhythmia and pneumonia. ,,,,
Specifically looking at the elderly population, Robinson et al. retrospectively reviewed 136 women over 65 and found that women undergoing RASC tend to be younger with less comorbidities, but similar ASA scores than those who underwent transvaginal repair.  Perioperatively the patients who underwent RASC had fewer post-operative complications with similar severity of complications but the overall complication rate was low.
Mesh complications are another concerning complication in prolapse surgery. A Cochrane review reveals that ASC has lower rates of dyspareunia than transvaginal mesh repairs.  The authors also reviewed three articles of transvaginal mesh repairs and found an overall mesh erosion rate of 18%, with 9% of these patients undergoing surgical correction. Erosion or extrusion has been reported in 0-10% of patients undergoing RASC. ,,,,,,,,,,, Most of these patients were treated conservatively with the use of transvaginal hormones as an initial therapy for transvaginal mesh exposure. , However, 1-10% of all patients ultimately required return to the operating room for mesh removal, which was most often performed transvaginally. ,,,,,,
| Cost|| |
Transvaginal techniques for prolapse repair have been utilized for their decreased operative time, decreased morbidity with a faster return to activities and in turn have been shown to decrease the cost.  The Cochrane review determined the procedure time is faster, hospital stays are shorter and the cost is decreased when performing transvaginal repair versus ASC, at the potential burden of poorer outcomes. 
Although minimally invasive techniques may provide comparable outcomes to open techniques, a concern with the use of advancing technology is cost. Judd et al. reported a cost-minimization analysis in 2010 based on data from previously published studies. The cost of RASC is greater than LASC or ASC despite a shorter hospital stay.  The biggest contributing factor was operating room time and cost of disposable equipment for the robot. Similarly, Paraiso et al.. used data from their RCT which showed that RASC has a higher cost than LASC, again driven by operating room costs.  In contrast, a cost-minimization analysis by Elliot et al.. from 2012 showed a 10% cost savings with RwWASC over ASC.  The factors that allowed for cost savings were a significantly shorter hospital stay in a hospital with large volume of cases. Of note, the difference in hospital stay between the two groups was 2.3 days and less patients in the RASC had concomitant procedures (89% vs. 58%). A randomized comparative effectiveness trial comparing costs of LASC and RASC (ACCESS trial) data has yet to be published. 
| Conclusions|| |
The surgical approach to treatment of POP has expanded with the use of minimally invasive surgery. Transvaginal approaches are less invasive, but that may be offset by lower long-term success rates without mesh and significant complication rates if the mesh is used. The gold standard ASC provides excellent durable anatomic outcomes, but with higher morbidity and increased cost compared to transvaginal repair. RASC allows for comparable outcomes with decreased morbidity; however, there is a question of further increased cost. It is important to discuss all options with patients and manage their expectations appropriately for optimal outcomes.
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[Figure 1], [Figure 2]
[Table 1], [Table 2]