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CASE REPORT
Year : 2012  |  Volume : 28  |  Issue : 4  |  Page : 442-444
 

Management of a renal calculus larger than 4 cm in a patient with tuberous sclerosis complex-associated angiomyolipoma


Department of Urology, Toyama City Hospital, Toyama, Japan

Date of Web Publication10-Jan-2013

Correspondence Address:
Koichi Kodama
Department of Urology, Toyama City Hospital, 2-1Imaizumi-hokubucho, Toyama 939-8511
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.105770

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   Abstract 

Renal calculi in patients with renal angiomyolipomas are difficult to treat because of the hemorrhagic potential of these tumors. We describe the case of a 65-year-old man having tuberous sclerosis complex-associated multifocal renal angiomyolipomas with a large renal calculus. The patient presented with left flank dullness and a previous history of spontaneous angiomyolipoma rupture. Intravenous pyelography revealed a 43 × 16 mm calculus in the pelvis and lower calyx of the left kidney. The calculus was successfully removed by retrograde flexible ureterorenoscopy and holmium-YAG lithotripsy. Flexible ureterorenoscopy is an effective, minimally invasive therapy for patients at high risk of renal hemorrhage.


Keywords: Angiomyolipoma, flexible ureterorenoscopy, nephrolithiasis, tuberous sclerosis complex


How to cite this article:
Kodama K, Takase Y, Motoi I. Management of a renal calculus larger than 4 cm in a patient with tuberous sclerosis complex-associated angiomyolipoma. Indian J Urol 2012;28:442-4

How to cite this URL:
Kodama K, Takase Y, Motoi I. Management of a renal calculus larger than 4 cm in a patient with tuberous sclerosis complex-associated angiomyolipoma. Indian J Urol [serial online] 2012 [cited 2019 Nov 18];28:442-4. Available from: http://www.indianjurol.com/text.asp?2012/28/4/442/105770



   Introduction Top


Tuberous sclerosis complex (TSC) is a genetic disorder that can affect almost all organ systems. Renal manifestations occur with high frequency, the most prevalent being angiomyolipoma (AML). TSC-associated AMLs tend to be larger, more numerous, and more likely to cause spontaneous hemorrhage compared with sporadic AMLs. Removal of renal calculi from kidneys with AMLs is particularly difficult because these tumors increase the potential for hemorrhage. We report the case of a 65-year-old man with TSC-associated AML and a renal calculus greater than 4 cm in his left kidney. The calculus was successfully removed by retrograde flexible ureterorenoscopy (F-URS) with holmium laser lithotripsy.


   Case Report Top


A 65-year-old man was admitted to our department with left flank dullness. He was previously diagnosed with TSC after being identified with the typical features, such as dermatological lesions (facial angiofibroma, ungual fibromas, and hypomelanotic macules on the toes), subependymal nodules, and multiple AMLs in both kidneys. While there was no family history of TSC, the patient had childhood epilepsy. He also experienced two episodes of hypovolemic shock concomitant with extensive retroperitoneal hemorrhage caused by spontaneous AML rupture, once in each kidney. Following the second episode, which occurred in the left kidney, he developed sepsis caused by Staphylococcus aureus, which was isolated from both venous blood and urine. He received conservative therapy without blood transfusion for both episodes of rupture.

Abdominal palpation revealed bilateral kidney enlargement without tenderness. Blood counts were within normal limits except for a low red blood cell count (331 × 10 4 /mm; normal, 430 × 10 4 -570 × 10 4 /mm), low hemoglobin (9.5 g/dl; normal, 13.5-17.0 g/dl), and a low hematocrit value (30.4%; normal, 40%-50%). Serum creatinine level was 1.0 mg/dl (normal, 0.6-1.1 mg/dl). Urinalysis demonstrated sterile pyuria with a negative urine culture. Kidney-ureter-bladder (KUB) radiography revealed a 43 × 16 mm renal calculus in the left kidney [Figure 1]a. Intravenous pyelography revealed that the calculus filled the pelvis and lower calyx, causing dilatation of the upper calyx [Figure 1]b. Abdominal enhanced computed tomography (CT) demonstrated a significant bilateral renal AML burden in addition to the renal calculus in the left kidney [Figure 2]. We decided to remove the renal calculus for several reasons, including the present clinical symptoms and a previous history of urinary tract infection. Minimally invasive retrograde F-URS with holmium laser lithotripsy was chosen because multiple renal AMLs have hemorrhagic potential.
Figure 1: (a) KUB radiography reveals a lower pole renal calculus in the left kidney. (b) Intravenous pyelography shows the calculus causing dilatation of the upper calyx

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Figure 2: Abdominal enhanced computed tomography demonstrates significant bilateral renal AML burden and a large renal calculus in the left kidney

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A 6.9-Fr F-URS, a 10-Fr ureteral access sheath, and a 200-μ holmium: YAG laser fibers were used for treatment. We attempted to vaporize the stone by "painting" the laser fiber over the stone surface. A 1.9-Fr nitinol basket, which minimizes the loss of deflection during F-URS, was used to extract large fragments and reposition them from the lower pole calyx into a position more readily accessible by the laser fiber, such as the renal pelvis or upper pole calyx. Complete stone fragmentation was achieved and a 4.8-Fr double pigtail stent was inserted. Total surgical duration was 195 minutes. The stone was composed of calcium phosphate. No evidence of greater than 2-mm residual stones was observed before removal of the ureteral stent in postoperative KUB radiography. On postoperative day 5, the stent was retrieved using the tether suture. Postoperative course was uneventful with gradual disappearance of clinical symptoms. Three months after surgery, KUB radiography confirmed the absence of any residual stones [Figure 3], and urinalysis was also revealed normal findings.
Figure 3: Three months after flexible ureterorenoscopy, follow-up KUB radiography confirms the absence of any residual stones

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   Discussion Top


Renal manifestations occur frequently in TSC. Rakowski et al. reported renal lesions in 57.5% TSC patients; of these, AML was present in 85.4%, cysts in 44.8%, and renal cell carcinoma in 4.2%. [1] TSC-associated AML is more likely to cause spontaneous hemorrhage compared with its sporadic counterpart, with a hemorrhagic risk of 25% to 50%.

TSC patients are also predisposed to nephrolithiasis because of both the disease and its treatments. For example, drugs like topiramate have proven to be effective for some forms of TSC-associated epilepsy; however, they also increase the risk of nephrolithiasis. Patients are also at higher risk for renal cystic disease because disruption of distal tubular function by a significant cyst burden leads to hypocitraturia. Our patient was not undergoing any treatment for epilepsy, and CT demonstrated no evidence of renal cystic lesions.

Traditional surgical treatment of renal calculi, including minimally invasive procedures like percutaneous nephrolithotomy (PNL) or extracorporeal shockwave lithotripsy (ESWL), may lead to bleeding in patients with renal AMLs. PNL remains a milestone technique with a high success rate and with a low percentage of major complications; however, the blood transfusion rate reported varies from 11.2% to 17.5%. [2] PNL involves puncture and dilation of the renal collecting system via the renal parenchyma and poses an unacceptable risk of hemorrhage in kidneys with AML, although there are two reported cases of PNL performed directly through a renal AML. [3],[4] On the other hand, ESWL requires large numbers of shock waves, which can lead to capillary damage with parenchymal or subcapsular hemorrhage; ESWL-induced retroperitoneal bleeding has been reported in a patient with renal AML. [5]

Recent studies have evaluated F-URS as an alternative treatment for patients with contraindications to PNL or ESWL, such as pregnant woman, obese patients, or those with coagulopathy. Indeed, F-URS using pulsed laser energy can fragment stones with less risk of hemorrhage. Furthermore, F-URS is a minimally invasive procedure that can treat <2-cm renal calculi with a low morbidity and high success rate. Our case and other reported cases indicate that F-URS can also safely treat larger stones. [6] However, the management of lower pole renal calculi with F-URS remains debatable because of limited access and poor clearance of stone fragments. [7] By the current literature, PNL should be considered the first line of treatment for greater than 2-cm lower pole renal calculi. [8] Further advances in endoscopic technology and techniques are required to resolve the limitations of F-URS, including the technical difficulty in removing large stones, intrarenal influx with infected stones, and prolonged surgical duration.

In conclusion, retrograde F-URS with holmium laser lithotripsy is an effective, minimally invasive therapy for patients at high risk of renal hemorrhage.

 
   References Top

1.Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA. Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors. Kidney Int 2006;70:1777-82.  Back to cited text no. 1
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2.Michel MS, Trojan L, Rassweiler JJ. Complications in percutaneous nephrolithotomy. Eur Urol 2007;51:899-906.  Back to cited text no. 2
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3.Kropp BP, Dabagia MD, Scott JW, Lingeman JE. Percutaneous nephrolithotomy directly through an angiomyolipoma. Urology 1994;44:915-7.  Back to cited text no. 3
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4.Eiley DM, Ozsvath B, Siegel DN, Smith AD. Percutaneous nephrolithotomy with renal angiomyolipomas: A rare challenge. J Endourol 1999;13:27- 30.  Back to cited text no. 4
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5.Gupta R, Dholaria P, Modi P, Rizvi J. Extracorporeal shock wave lithotripsy-induced retroperitoneal hemorrhage in a case of upper ureteral calculus with angiomyolipoma. Urol J 2011;8:72-4.  Back to cited text no. 5
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6.Mariani AJ. Combined electrohydraulic and holmium: YAG laser ureteroscopic nephrolithotripsy of large (greater than 4 cm) renal calculi. J Urol 2007;177:168-73.  Back to cited text no. 6
[PUBMED]    
7.Preminger GM. Management of lower pole renal calculi: Shock wave lithotripsy versus percutaneous nephrolithotomy versus flexible ureteroscopy. Urol Res 2006;34:108-11.  Back to cited text no. 7
[PUBMED]    
8.Pardalidis NP, Andriopoulos NA, Sountoulidis P, Kosmaoglou EV. Should percutaneous nephrolithotripsy be considered the primary therapy for lower pole stones? J Endourol 2010;24:219-22.  Back to cited text no. 8
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    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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