Indian Journal of Urology Users online:2451  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
  Table of Contents 
SURGICAL CRAFT
Year : 2012  |  Volume : 28  |  Issue : 3  |  Page : 362-365
 

Laparoscopic en bloc kidney transplantation


Smt. G R Doshi and Smt. K M Mehta Institute of Kidney Diseases and Research Centre, Dr H L Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India

Date of Web Publication19-Oct-2012

Correspondence Address:
Pranjal Modi
Professor of Urology and Transplantation Surgery, Smt. G R Doshi and Smt. K M Mehta Institute of Kidney Diseases and Research Centre, Dr H L Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad - 380 016, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.102731

Rights and Permissions

 
   Abstract 

Laparoscopic donor nephrectomy is well establish procedure and having advantages over open donor nephrectomy in terms of having less pain, early ambulation and rapid post operative recovery. To extend the advantages of laparoscopic surgery to the recipient, recently we have performed laparoscopic kidney transplantations when kidney was procured from deceased donors. As a further extension of the procedure, here we present a case of laparoscopic en bloc kidney transplantation in obese diabetic recipient who received kidneys from 70 year old non-heart beating donor.


Keywords: Expanded criteria donor, en bloc, kidney transplantation, laparoscopy


How to cite this article:
Modi P, Thyagaraj K, Rizvi SJ, Vyas J, Padhi S, Shah K, Patel R. Laparoscopic en bloc kidney transplantation. Indian J Urol 2012;28:362-5

How to cite this URL:
Modi P, Thyagaraj K, Rizvi SJ, Vyas J, Padhi S, Shah K, Patel R. Laparoscopic en bloc kidney transplantation. Indian J Urol [serial online] 2012 [cited 2019 Nov 14];28:362-5. Available from: http://www.indianjurol.com/text.asp?2012/28/3/362/102731



   Introduction Top


Laparoscopic surgery has distinct advantages over open surgery in terms of less pain, early ambulation, rapid convalescence and better cosmesis. These advantages are present both for upper abdominal surgery like donor nephrectomy and also for lower abdominal surgery like hernia repair. [1],[2],[3],[4],[5] In the scenario of kidney transplantation, the recipient operation is performed by open surgery. Recently, we have described the feasibility and safety of laparoscopic kidney transplantation when graft was obtained from deceased donor. [6] In this series of four patients, in comparison to open surgical approach, the incision size was much smaller and overall outcome in terms of creatinine clearance was the same as open kidney transplantation procedure performed from the same deceased donor.

Due to scarcity of the organs available for kidney transplantation many centers have started accepting kidney from expanded criteria brain dead deceased donors and donation after cardiac death (DCD). Transplantation of two kidneys in one recipient from expanded criteria deceased donor has a better outcome compared to when kidney was transplanted individually in two different recipients. [7],[8],[9] Both kidneys are transplanted in either monolateral or bilateral iliac fossa. [10],[11] A single large incision or two different incisions in the lower abdomen are usually required for performing such an operation. Incision-related morbidity, especially in the setup of transplantation is well known. To avoid such morbidity we report a case of laparoscopic en bloc transplantation from a non-heart-beating deceased donor.


   Materials and Methods Top


An en bloc kidney graft was obtained from a 70-year-old non-hypertensive, non-diabetic female donor after her cardiac death (Maastricht Category III). Her terminal serum creatinine value was 1.5 mg/dl. Rapid procurement technique was used and in situ perfusion carried out with Histidine-tryptophane-ketoglucarate fluid. Kidneys were removed en bloc; both kidneys had small multiple cysts. There was no extensive atherosclerosis in the aorta and renal vessels. On bench, the suprarenal aorta and vena cava were closed by polypropylene suture material and openings of lumbar vessels were closed. The cold ischemia time was 11 h. The recipient was a 55-year-old female with diabetic nephropathy and on thrice a week maintenance hemodialysis for one and a half years. Her body mass index was 30.1 kg/m 2 . She had two abdominal scars; one paramedian 20-cm long scar for emergency appendicectomy performed 35 years back and, another midline vertical scar from symphysis pubis to umbilicus for purpose of cesarean section performed 27 years back. Gray scale ultrasound and color Doppler study of external iliac vessels showed normal flow pattern and no calcification in the arterial wall.

Operative procedure

Patient was placed in supine position and with right arm extended and left arm placed to the side of the patient. General anesthesia with endotracheal intubation was performed and radial artery on right side was cannulated for blood pressure measurement and for blood gas analysis during operative procedure. Four ports were placed as described previously. [6] Division of a few intra-abdominal adhesions was carried out. In 20-degree Trendlenberg position, bowel loops were retracted upwards and iliac vessels dissected. A midline suprapubic 5-cm incision was placed and en bloc kidney allograft was placed into the peritoneal cavity. Wound was closed and pneumoperitoneum was reestablished. End to side anastomosis between the infrarenal vena cava and external iliac vein and aorta and external iliac artery was carried out using 5/0 polypropylene suture material [Figure 1],[Figure 2],[Figure 3] and [Figure 4]. Both ureters were reimplanted separately by the Lich-Gregoir method in bladder without stents [Figure 5]. One kidney was placed over the psoas muscle and was retroperitonealized while the other was placed in the peritoneal cavity and its capsule was sutured to the posterior peritoneum.
Figure 1: Dissected external iliac artery and vein laparoscopically. Both kidneys are lying in the peritoneal cavity

Click here to view
Figure 2: Infra-renal vena cava anastomoses to the external iliac vein. Posterior wall anastomosis is completed and anterior wall anastomosis is in progress. Vessel loop and hem o lok clips controlling the distal part of the external iliac vein are seen

Click here to view
Figure 3: External iliac arteriotomy length extended to the diameter of the infra-renal aorta

Click here to view
Figure 4: Completed anastomosis between the inferior vena cava and external iliac vein and, aorta and external iliac artery in end to side fashion

Click here to view
Figure 5: Both ureters reimplanted into bladder separately

Click here to view


Drain tube was placed through lower 5-mm port site and port site wounds were closed.

Patient received rabbit-antithymocyte globulin as induction immunosuppressant and subsequently, tacrolimus, mycophenolic acid and prednisolone-based therapy was given.


   Results Top


Vascular anastomosis time was 50 min and there was no significant leak. Both kidneys became pink; turgidity was assessed by pressing kidneys with suction cannula and was found to be satisfactory. Urine output was present from both kidneys. Estimated blood loss was 100 ml and operative time was 3 h and 40 min.

Postoperatively, patient had right-side pneumonia and required intensive care unit admission for five days. There was no analgesic drug required and her visual analogue score remained between 0-1 for the first 72 h. She had delayed graft function for eight days and required hemodialysis four times. At the end of one month her serum creatinine value was 1.38 mg/dL and Diethyl Trimethyl Penta Acetic Acid renal scan showed 39.25 ml/min/1.73 m 2 glomerular filtration rate [Figure 6]. At six months of follow-up serum creatinine value is 1.39 mg/dL and color Doppler study shows normal perfusion of both kidneys.
Figure 6: DTPA renal scan is showing perfusion of both kidneys

Click here to view



   Discussion Top


Laparoscopic surgery has its established role for living donor nephrectomy in the scenario of kidney transplantation. Several prospective randomized trials have proved that patients undergoing laparoscopic donor nephrectomy have less pain, early ambulation, rapid convalescence and better cosmesis compared to open-donor nephrectomy.

Open kidney transplantation procedure is a well-established procedure and usually performed in one of the iliac fossa. Various incisions are described to have optimum exposure of the iliac vessels and urinary bladder for technically successful transplantation. The risk factors related to wound complications are well described in general surgery; transplant recipients have additional risk factors in terms of immunosuppressants.

Dual kidney transplantation requires either a single large incision when both kidneys are transplanted in the ipsilateral iliac fossa or two incisions in the right and left iliac fossa. A single large incision or multiple incisions give more pain and other wound-related morbidity. This is especially true for obese recipients who have further risk of wound infection. To minimize wound-related complications reduction in size of incision is successfully carried out. [12] However, in obese recipients, small incision for transplantation may lead to excessive traction of the wound and subsequently hematoma of the muscle and more pain. Further, in obese recipients, access to the pelvic vessels and bladder for vascular anastomosis and ureteral reimplantation respectively is challenging through a small incision. Our patient was obese and had previous history of multiple abdominal operations.

Recently, we and others have described the feasibility of laparoscopic kidney transplantation (LKT) or robotic kidney transplantation. [6],[13],[14],[15] As a further extension of the procedure of LKT we have performed en bloc kidney transplantation from DCD donor. A large arteriotomy and venotomy is required to anastomose the aorta and inferior vena cava to the external iliac vessels. Compared to two separate transplantations, en bloc transplantation reduces the number and total time of vascular anastomosis. En bloc kidney transplantation is preferred for pediatric renal allograft. In the absence of significant atherosclerosis of the aorta and renal arteries, en bloc transplantation of kidneys is not a major problem. We do not recommend such transplantation in the presence of severe atherosclerosis. A theoretical risk of ischemia to the ipsilateral lower limb due to "vascular steal" may arise. However, "stealing" of blood supply could also occur in monolateral dual kidney transplantation. We did not find such complications in our previous experience of open dual kidney transplantation. [10] To avoid torsion of the one or both kidneys, one of the kidneys was retroperitonealized and the other was fixed to the posterior peritoneum by taking few tugging sutures through its capsule.

Ureteroneocystostomy is used either by joining both ureters on the bench and making a single lumen to implant into the bladder, or both ureters are implanted separately. We prefer to implant both ureters separately to provide adequate submucosal tunnel and anti-reflux mechanism. [16]

Transplantation from expanded criteria deceased donor as defined by the United Network of Organ Sharing (UNOS) is a well-accepted modality of treatment to reduce the discrepancy between demand and supply of the organs for transplantation. [17] Currently, there are no clear indications for dual kidney transplantation when the kidney is procured from DCD donors. We applied the same criteria laid down by the UNOS for dual kidney transplantation from brain dead patient and accepted graft as DCD- expanded criteria donor.

In conclusion, this is the first case report of laparoscopic en bloc kidney transplantation performed successfully.

 
   References Top

1.Wolf JS, Merion RM, Leichtman AB, Campbell DA Jr, Magee JC, Punch JD, et al. Randomized controlled trial of hand-assisted laproscopic versus open surgical, live donor nephrectomy. Transplantation 2001;72:284-90.  Back to cited text no. 1
    
2.Brook NR, Harper SJ, Bagul A, Elwell R, Nicholson ML. Laparoscopic donor nephrectomy yields kidney with structure and function equivalent to those retrieved by open surgery. Transplant Proc 2005;37:625-6.  Back to cited text no. 2
[PUBMED]    
3.Oyen O, Andersen M, Mathisen L, Kvarstein G, Edwin B, Line PD, et al. Laparoscopic versus open living donor nephrectomy: Experience from a prospective, randomized single-center study focusing on donor safety. Transplantation 2005;79:1236-40.  Back to cited text no. 3
    
4.Andersen MH, Mathisen L, Oyen O, Edwin B, Digernes R, Kvarstein G, et al. Postoperative pain and convalescence in living kidney donors- laparoscopic versus open donor nephrectomy: A randomized study. Am J Transplant 2006;6:1438-43.  Back to cited text no. 4
[PUBMED]    
5.Mc Cormack K, Scott NW, Go PM, Ross S, Grant AM. EU Hernia Trialist Collaboration. Laparoscopic techniques versus open techniques for inguinal hernia repair. Cochrane Database Syst Rev 2003;1:CD001785.  Back to cited text no. 5
    
6.Modi P, Rizvi SJ, Pal B, Bharadwaj R, Trivedi P, Patel K, et al. Laparoscopic kidney transplantation: An initial experience. Am J Transplant 2011;11:1320-4.   Back to cited text no. 6
    
7.Remuzzi G, Cravedi P, Perna A, Dimitrov BD, Turturro M, Locatelli G, et al. Long-term outcome of renal transplantation from older donors. N Engl J Med 2006;354:344-52.  Back to cited text no. 7
[PUBMED]    
8.Bunnapradist S, Gritsch HA, Peng A, Jordan SC, Cho YW. Dual kidneys from marginal adult donors as a source for cadaveric renal transplantation in the United States. J Am Soc Nephrol 2003;14:1031-6.  Back to cited text no. 8
    
9.Lucarelli G, Bettocchi C, Battaglia M, Impedovo SV, Vavallo A, Grandaliano G, et al. Extended criteria donor kidney transplantation: Comparative outcome analysis between single versus double kidney transplantation at 5 years. Transplant proc 2010;42:1104-7.  Back to cited text no. 9
[PUBMED]    
10.Modi P, Rizvi J, Pal B, Trivedi H, Shah V, Modi M, et al. Dual kidney transplantation from expanded criteria deceased donors: Initial experience from single center. Indian J Urol 2011;27:29-32.  Back to cited text no. 10
    
11.Ekser B, Baldan N, Margani G, Furian L, Frison L, Valente L, et al. Monolateral placement of both kidneys in dual kidney transplantation: Low surgical complication rate and short operating time. Transpl Int 2006;19:485-91.  Back to cited text no. 11
    
12.Oyen O, Scholz T, Hartmann A, Pfeffer P. Minimally invasive laparoscopic transplantation: The first experience. Transplant Proc 2006;38:2798-802.  Back to cited text no. 12
    
13.Rosales A, Salvador JT, Urdaneta G, Patiño D, Montlleó M, Esquena S, et al. Laparoscopic kidney transplantation. Eur Urol 2010;57:164-7.  Back to cited text no. 13
    
14.Giulianotti P, Gorodner V, Sbrana F, Tzvetanove I, Jeon H, Blanco F, et al. Robotic transabdominal kidney transplantation in a morbidly obese patient. Am J Transplant 2010;10:1478-82.  Back to cited text no. 14
    
15.Boggi U, Vistoli F, Signori S, D'lmporzano S, Amorese G, Consani G, et al. Robotic renal transplantation: First European case. Transplant Int 2011;10:2708-11.  Back to cited text no. 15
    
16.Modi P, Gupta R, Rizvi S. Laparoscopic ureteroneocystostomy and psoas hitch for post-hysterectomy ureterovaginal fistula. J Urol 2008;180:615-7.  Back to cited text no. 16
    
17.Moore PS, Farney AC, Sundberg AK, Rohr MS, Hartmann EL, Iskandar SS, et al. Dual kidney transplantation: A case-control comparison with single kidney transplantation from standard and expanded criteria donors. Transplantation 2007;83:1551-6.  Back to cited text no. 17
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]

This article has been cited by
1 Retroperitoneoscopic living-donor nephrectomy and laparoscopic kidney transplantation: Experience of initial 72 cases
Modi, P. and Pal, B. and Modi, J. and Singla, S. and Patel, C. and Patel, R. and Padhy, S. and T, K. and Patel, K. and Rizvi, J. and Sharma, S. and Sharma, V. and Modi, M. and Shah, V.R. and Trivedi, H.L.
Transplantation. 2013; 95(1): 100-105
[Pubmed]



 

Top
Print this article  Email this article
 

    

 
   Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (2,246 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
    Materials and Me...
   Results
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed2862    
    Printed74    
    Emailed0    
    PDF Downloaded97    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

HEALTHWARE INDIA