| SYMPOSIUM |
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| Year : 2011 | Volume
: 27
| Issue : 1 | Page : 110-120 |
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Genetic and epigenetic factors: Role in male infertility
MB Shamsi, K Kumar, R Dada
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
Correspondence Address:
R Dada
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi-29
India
DOI: 10.4103/0970-1591.78436 PMID: 21716934
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Genetic factors contribute upto 15%-30% cases of male infertility. Formation of spermatozoa occurs in a sequential manner with mitotic, meiotic, and postmeiotic differentiation phases each of which is controlled by an intricate genetic program. Genes control a variety of physiologic processes, such as hypothalamus-pituitary-gonadal axis, germ cell development, and differentiation. In the era of assisted reproduction technology, it is important to understand the genetic basis of infertility to provide maximum adapted therapeutics and counseling to the couple. |
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