Indian Journal of Urology Users online:839  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
  Table of Contents 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 26  |  Issue : 4  |  Page : 490-493
 

Prospective analysis of psychological distress in men being investigated for prostate cancer


Department of Urology, Amrita Insititute of Medical Sciences and Research Center, Kochi, Kerala, India

Date of Web Publication31-Dec-2010

Correspondence Address:
Santosh A Jadhav
Department of Urology, Amrita Institute of Medical Sciences, Kochi, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.74436

Rights and Permissions

 
   Abstract 

Objectives : To determine the level and prevalence of anxiety and depression in men being investigated for prostate cancer (CaP) and also to identify those aspects of the diagnostic pathway that induces the most stress.
Materials and Methods : All patients undergoing transrectal ultrasound-guided biopsy (TRUS-B) of the prostate for suspected CaP at our institute between June 2008 and April 2009 were enrolled in this prospective study. All patients completed two questionnaires, prior to their biopsy (HADS1) and before receiving results (HADS2), containing the Hospital Anxiety and Depression Scale (HADS). The data were analyzed and the differences in HADS were compared.
Results : A total of 112 men were included in the trial. Two patients could not complete the second part of HADS (HADS2) and were excluded from the study. Prevalence of anxiety among the 110 patients was 43/110 (39.1%). Mean score for anxiety in these 43 patients before biopsy (HADS A1) was 10.74 and score just before receiving the biopsy report (HADS A2) was 11.55. Prevalence of depression before TRUSB (HADS D1) was 21/110 (19.1%) with a mean score of 10.59. Prevalence of depression while awaiting the biopsy report (HADS D2) was 22/110 (20%) with mean score of 10.62.
Conclusion : There was a high prevalence of anxiety and depression in our study population and waiting for biopsy results was the most stressful event. Questionnaires such as HADS can identify patients with psychological distress. Minimizing the stress while waiting for a diagnosis should help optimize patient care.


Keywords: Anxiety, depression, prostate cancer, transrectal ultrasound guided prostate biopsy


How to cite this article:
Jadhav SA, Sukumar S, Kumar G, Bhat SH. Prospective analysis of psychological distress in men being investigated for prostate cancer. Indian J Urol 2010;26:490-3

How to cite this URL:
Jadhav SA, Sukumar S, Kumar G, Bhat SH. Prospective analysis of psychological distress in men being investigated for prostate cancer. Indian J Urol [serial online] 2010 [cited 2019 Sep 15];26:490-3. Available from: http://www.indianjurol.com/text.asp?2010/26/4/490/74436



   Introduction Top


The high prevalence of anxiety in patients with cancers is well recognized, [1],[2] but studies on the prevalence of anxiety and depression in patients who specifically have or are at risk for prostate carcinoma (CAP) are limited. [3]

One neglected area of our current understanding for health-related quality of life and decision-making in CAP is the role of patient anxiety, and our current knowledge remains fragmentary; this work is an attempt to understand it for the betterment of patients. To assess the psychological distress in patients being evaluated for CAP, we studied the levels of anxiety and depression in individuals being evaluated with serum prostate specific antigen (PSA) levels and transrectal ultrasound-guided biopsy (TRUSB).


   Materials and Methods Top


All male patients above the age of 50 years have a digital rectal examination (DRE) and serum PSA estimation at our outpatient clinic; those with an abnormal DRE and/or elevated PSA (>4 ng/ml) are then advised to undergo TRUSB. All such patients undergoing TRUSB for suspected CAP between June 2008 and August 2009 were enrolled in this prospective study.

Patients with bleeding diathesis, anticoagulation therapy, painful perianal conditions or lidocaine allergy, as well as those who could not complete the questionnaires were excluded from the study.

Once selected to undergo TRUSB, patients were counseled and prepared as per a protocol that had been approved by the institute ethics committee. All patients were counseled regarding the need for biopsy, nature of the procedure, and possible outcomes of biopsy. An informed consent was obtained prior to biopsy and the Hospital Anxiety and Depression Scale (HADS1) questionnaire [Table 1] in the local language was completed. Transrectal ultrasound guided ten-core biopsies were taken under local anesthesia as per the hospital protocol. All patients returned home after a brief period of observation and were reviewed after 1 week. Prior to receiving the biopsy report, they once again completed the questionnaire containing the Hospital Anxiety and Depression Scale (HADS2).
Table 1 :Anxiety and depression scoring sheet


Click here to view


HADS has two subscales: HADS-anxiety subscale and HADS-depression subscale. Seven questions relate to symptoms of depression and seven to anxiety over the previous week; response to each question is graded as 0-3. The maximum score is 21 on the anxiety and depression subscales. The thresholds for case identification are defined as 8-10 (mild), 11-14 (moderate), 15-21 (severe).

After completing the HADS2 questionnaires, biopsy report was disclosed to patients. Patients with histological evidence of CAP were planned for definitive treatment based on other clinicopathological factors while those with a noncancer diagnosis were counseled accordingly.

A single surgeon (SJ) was involved in counselling patients, performing the biopsy and informing the results. The data were reviewed and statistical analysis done using SPSS 11 software.


   Results Top


Here 112 consecutive men satisfying the criteria for undergoing a TRUSB were included in this study. However, only 110 patients completed both questionnaires. Two patients could not complete the HADS2 due to heightened anxiety and were thus excluded from the study after being informed of the biopsy report over telephone. Data from the remaining 110 patients was studied [Table 2]. Mean age of patients was 64.62 (range: 39-81) years. The time gap between biopsy and disclosure of report was 7 days in all patients.
Table 2 :Anxiety and depression scores in 110 patients assessed before biopsy and before informing report


Click here to view


Prevalence of anxiety before TRUSB (HADS A1) was 43/110 (39.1%) and while awaiting the biopsy report (HADS A2) was 60/110 (54.5%). Mean score for anxiety in these 43 patients before biopsy (HADS A1) was 10.74 and score just before receiving the biopsy report (HADS A2) was 11.55; this rise in score while awaiting biopsy results was statistically significant (P value 0.002).

Prevalence of depression before TRUSB (HADS D1) was 21/110 (19.1%). Mean score in these men was 10.59. Prevalence of depression while awaiting the biopsy report (HADS D2) was 22/110 (20 %) with mean score of 10.62. This rise in score was not statistically significant.


   Discussion Top


Psychological distress after a diagnosis of any cancer is well recognized. In a study of newly diagnosed breast cancer, even psychiatric disorders were found in 34-46% of patients. [1] In another study of 117 outpatients aged 21-75 years with various forms of newly diagnosed cancer, over a quarter had significant psychological distress with anxiety (26%) being more common than depression (7%). [2] Other similar studies have confirmed relatively high levels of psychopathology in a wide range of patients with cancer. [4],[5]

Four validated scales for measuring anxiety have been used in studies of patients with CAP during various stages of evaluation including screening: [6] State-Trait Anxiety Inventory (STAI), [7] Hospital Anxiety and Depression Scale (HADS), [8] Impact of Event Scale (IES), [9],[10] and the Memorial Anxiety Scale for Prostate Cancer (MAX-PC). [11] The HADS [8],[12] is a 14-item scale specifically designed for patients with medical illnesses as it excludes somatic items and relies only on emotional symptoms of depression and anxiety. It has been extensively validated in cancer populations. [13],[14]

Our analysis shows significant stress levels in patients with suspected CAP who are being investigated to confirm or eliminate the diagnosis. The levels of depression were slightly less than the anxiety levels and remained constant during both stages of the assessment. The anxiety levels vary during the clinical timeline from a positive rectal examination and/or an elevated PSA level. Our observation showed an increase in the number of anxious subjects during the wait for the results of TRUSB; also there was a significant increase in the severity of the anxiety levels during the same period. This heightened anxiety while awaiting the results of TRUSB has been previously described in a similar population of men being screened for CAP. [3] This variation has been thought to be a response to the uncertainty of diagnosis. [6]

The curiosity to know the result of any diagnostic test often produces a certain amount of anxiety. A normal/benign report often provides reassurance and decreases anxiety in this setting. [15] In fact, anxiety levels may even decrease after a diagnosis of cancer, although not to the levels of a noncancer diagnosis. This demonstrates a general anxiety-relief value for biopsy results in men who have elevated PSA, thereby suggesting the anxiolytic role of information receipt, even when the information received is not the preferred outcome! [16],[17]

Before assessing the results of anxiety levels in men who are screened for or have CAP, we need to know the baseline anxiety levels in the population at risk for CAP. Unfortunately, exact prevalence rates of baseline anxiety in this at-risk population in the Indian scenario do not exist. In the United States, 1-year prevalence estimate of anxiety disorders is reported to be 11.4% in population above age of 55 years. [18]

Our study included only patients selected from the general urology outpatient clinics and did not necessarily include those at high risk of harboring CAP. However, existing literature has shown an additional 20% aggravated anxiety in first degree relatives of CAP patients compared to those with no family history of CAP. [19]

Our analysis did not show a significant change in depression levels during the wait. Although intriguing, it is possible that patients receiving an unfavorable result (diagnosis of cancer) may eventually show an increased level of depression; this needs to be evaluated in larger numbers.

The relatively high level of psychopathology suggests that for most men being evaluated for CAP, there is need for good counseling while awaiting biopsy results. Based on our assessment, we have now streamlined our biopsy procedure to include detailed counseling and early disclosure of biopsy results. There is also a need to provide adequate support and information to all patients as part of routine care; for this we now involve the medical social worker and if needed a clinical psychologist also.


   Conclusion Top


There is a high incidence of clinically significant anxiety and depression in men being investigated for prostate cancer. Uncertainty about the future while awaiting biopsy results after TRUSB seem to be the most stressful event in patients' lives and minimizing this wait should help optimize patient care. Questionnaires such as HADS may identify patients with psychological distress who may benefit from early counseling.

 
   References Top

1.Ellman R, Angeli N, Christians A, Moss S, Chamberlain J, Maguire P. Psychiatric morbidity associated with screening of breast cancer. Br J Cancer 1989;60:781-4.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Ford S, Lewis S, Fallowfield L. Psychological morbidity in newly referred patients with cancer. J Psychosomatic Res 1995;39:193-202.  Back to cited text no. 2
    
3.Awsare NS, Green JS, Aldwinckle B, Hanbury DC, Boustead GB, McNichlas TA. The measurement of psychological distress in men being investigated for presence of prostate cancer. Prostate Cancer Prostatic Dis 2008;11:384-9.   Back to cited text no. 3
    
4.Derogatis LR, Morrow GR, Fetting J, Penman D, Piasetsky S, Schmale AA, et al. The prevalence of psychiatric disorders among cancer patients. JAMA 1983;249:751-7.  Back to cited text no. 4
    
5.Hopwood P, Howell A, Maguire P. Psychiatric morbidity in patients with advanced cancer of the breast: prevalence measured by two self-rating questionnaires. Br J Cancer 1991;64:349-52.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Dale W, Bilir P, Han M, Meltzer D. The role of anxiety in prostate carcinoma: a structured review of the literature. Cancer 2005;104:467-78.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  
7.Speilberger CD, Gorschuch RL, Lushene RE. STAI manual for the state-trait anxiety inventory. Palo Alto: Consulting Psychologists Press; 1970.   Back to cited text no. 7
    
8.Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002;52:69-77.  Back to cited text no. 8
[PUBMED]  [FULLTEXT]  
9.Horowitz M, Wilner N, Alvarez W. Impact of Event Scale: a measure of subjective stress. Psychosomatic Medicine 1979;41:209-18.  Back to cited text no. 9
[PUBMED]  [FULLTEXT]  
10.Weiss ES, Marmar CR. The Impact of Event Scale-revised. In, Wilson JP, Keane TM, editors. Assessing psychological trauma in PTSD. New York: Guilford; 1997. P. 399-411.  Back to cited text no. 10
    
11.Roth AJ, Rosenfeld B, Kornblith AB, Gibson C, Scher HI, Curley-Smart T, et al. The Memorial Anxiety Scale for Prostate Cancer: validation of a new scale to measure anxiety in men with prostate cancer. Cancer 2003;97:2910-8.   Back to cited text no. 11
[PUBMED]  [FULLTEXT]  
12.Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-70.   Back to cited text no. 12
[PUBMED]    
13.Morasso G. Screening adjustment disorders related to mastectomy and its treatment. New Trends Exp Clin Psychiatry 1997;13:90-3.  Back to cited text no. 13
    
14.Razavi D, Delvaux N, Bredart A, Paesmans M, Debusscher L, Bron D, et al. Screening for psychiatric disorders in a lymphoma out patient population. Eur J Cancer 1992;28:1869-72.  Back to cited text no. 14
    
15.Essink-Bot ML, Koning HJ, Hijs HG, Kirkels WJ, Van der Maas PJ, Schroder FH. Short-term effects of population based screening for prostate cancer on health-related quality of life. J Natl Cancer Inst 1998;90:925-31.  Back to cited text no. 15
    
16.Mishel MH. Uncertainty in illness. IMAGE: J Nurs Scholar 1988;20:225-32.  Back to cited text no. 16
    
17.Rainey LC. Effects of preparatory patient education for radiation oncology patients. Cancer 1985;56:1056-61.  Back to cited text no. 17
[PUBMED]    
18.U.S. Department of Health and Human Services. Mental health: a report of the Surgeon General. Rockville: U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, National Institutes of Health, National Institute of Mental Health, 1999.  Back to cited text no. 18
    
19.Cornier L, Valeri A, Azzouzi R. Worry and attitute of men in at risk families for prostate cancer about genitic susceptibility and genetic testing. Prostate 2002;51:276-85.  Back to cited text no. 19
    



 
 
    Tables

  [Table 1], [Table 2]

This article has been cited by
1 Psychological stress assessment of patients suffering from prostate cancer
Seklehner, S. and Hladschik-Kermer, B. and Lusuardi, L. and Schabauer, C. and Riedl, C. and Engelhardt, P.F.
Scandinavian Journal of Urology. 2013; 47(2): 101-107
[Pubmed]
2 Psychological stress assessment of patients suffering from prostate cancer
Stephan Seklehner,Birgit Hladschik-Kermer,Lukas Lusuardi,Christoph Schabauer,Claus Riedl,Paul F. Engelhardt
Scandinavian Journal of Urology. 2013; 47(2): 101
[Pubmed] | [DOI]
3 Prostate biopsy in the left lateral decubitus position is less painful than prostate biopsy in the lithotomy position: A randomized controlled trial
Lodeta, B., Lodeta, M.
Korean Journal of Urology. 2012; 53(2): 87-91
[Pubmed]
4 Development and Validation of a Disease-Specific Scale to Assess Psychosocial Well-Being of Patients Living With Unruptured Intracranial Aneurysm
Fujishima-Hachiya, A. and Inoue, T.
Journal of Neuroscience Nursing. 2012; 44(6): 317-325
[Pubmed]
5 Prostate Biopsy in the Left Lateral Decubitus Position is Less Painful than Prostate Biopsy in the Lithotomy Position: A Randomized Controlled Trial
Branimir Lodeta,Maja Lodeta
Korean Journal of Urology. 2012; 53(2): 87
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
 

    

 
   Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (340 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Introduction
    Materials and Me...
    Results
    Discussion
    Conclusion
    References
    Article Tables

 Article Access Statistics
    Viewed4236    
    Printed126    
    Emailed1    
    PDF Downloaded83    
    Comments [Add]    
    Cited by others 5    

Recommend this journal

HEALTHWARE INDIA