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EVIDENCE BASED UROLOGY
Year : 2010  |  Volume : 26  |  Issue : 1  |  Page : 133-138

Maximal androgen blockade for advanced prostate cancer


Department of Urology, Christian Medical College Vellore, Vellore - 632 004, India

Correspondence Address:
Rajiv Paul Mukha
Department of Urology, Christian Medical College Vellore, Vellore - 632 004
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.60463

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Prostate cancer has now become one of the leading types of cancer in urban India. It is now the third most common cancer in Delhi. As we advance in health care with the resultant increase in longevity, we will be seeing more of advanced carcinoma prostate. Since the early 1980.s, there have been many trials on MAB. However, the question remains whether these agents actually make a difference? The role of MAB is probably limited to the prevention of the ß are reaction in patients on LHRH agonists. The non steroidal antiandrogens have a marginal benefit of increased overall survival by approximately 3% to 5% at 5 ve years. There may be a role for MAB in patients with metastatic carcinoma of prostate, low volume metastases, patients with M 1 disease with absence of metastases in the skull, ribs, long bones, and soft tissues excluding lymph nodes.


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