|Year : 2006 | Volume
| Issue : 4 | Page : 322-325
Does estimation of prostate volume by abdominal ultrasonography vary with bladder volume: A prospective study with transrectal ultrasonography as a reference
Shivadeo S Bapat, Satyajeet S Purnapatre, Ketan V Pai, Pushkaraj Yadav, Abhijit Padhye, YG Bodhe
Department of Urology, Maharashtra Medical Foundationís, Ratna Memorial Hospital, 986 Senapati Bapat Road, Pune - 411 004, India
Shivadeo S Bapat
Janhavi 797/4, Bhandarkar Institute Road, Pune - 411 004
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Objectives: Ultrasonography (USG) is the commonest modality for ascertaining prostate volume. Urologists commonly encounter a discrepancy between prostate volume on USG and actual volume of prostate, whereas transrectal ultrasonography (TRUS) gives near correct prostate volume. We undertook a prospective study to compare the relationship between changing bladder volumes to the volume of prostate. Materials and Methods: After approval of the Institutional Ethics Committee and informed consent, 25 patients (age group: 52-78 years) with lower urinary tract symptoms were assessed for prostate volume by USG at different bladder volumes and final comparison was done with TRUS in one setting. Each USG and TRUS was done by one urology resident under the guidance of one qualified radiologist with experience of over 15 years in this field. Equipment used was SIEMENS SONNOLINE ADARA with 3.5 MHz probe for USG and 7.5 MHz Endo p-2 (biplaner) probe for TRUS. First, patients were asked to empty their bladder and post void residual urine was measured along with prostate volume. Patients were given oral fluids and USG was repeated serially at three intervals with bladder volume of 100-200 ml, 200-300 ml and > 300 ml. Finally uroflowmetry was carried out followed by TRUS. Results were recorded in a tabulated form on 'Excel spread sheet'. Results: 1. Measurement of prostate volume increases with increase in bladder volume. 2. Calculated prostate volume at minimal bladder capacity (100-200 ml) was found to be the closest to the volume calculated by TRUS. Conclusion: Minimal bladder volume (100-200 ml) is essential for near correct estimation of prostate volume by USG. With increasing bladder volume, the volume of prostate increases disproportionate to its actual volume.
Keywords: Abdominal ultrasonography, transrectal ultrasonography, volume of bladder, volume of prostate
|How to cite this article:|
Bapat SS, Purnapatre SS, Pai KV, Yadav P, Padhye A, Bodhe Y G. Does estimation of prostate volume by abdominal ultrasonography vary with bladder volume: A prospective study with transrectal ultrasonography as a reference. Indian J Urol 2006;22:322-5
|How to cite this URL:|
Bapat SS, Purnapatre SS, Pai KV, Yadav P, Padhye A, Bodhe Y G. Does estimation of prostate volume by abdominal ultrasonography vary with bladder volume: A prospective study with transrectal ultrasonography as a reference. Indian J Urol [serial online] 2006 [cited 2020 Jul 12];22:322-5. Available from: http://www.indianjurol.com/text.asp?2006/22/4/322/29114
Abdominal ultrasonography (USG) is the commonest modality for ascertaining prostate volume. It is commonly observed that there is a discrepancy in the volume of prostate measured by USG and actual volume of prostate. We also encountered discrepancy in the USG report of prostate volume calculated by the same sonologist on the same patient with one machine but performed at two different times. We undertook this study to ascertain whether increasing bladder volume affects measurements of prostate volume since bladder acts as a window through which prostate is visualized. Transrectal ultrasonography (TRUS) gives near correct prostate volume, with which we compared our results. A study of a large number of patients is required to come to a definite conclusion. This is an ongoing study and we herewith present our initial data of 25 patients.
| Materials and Methods|| |
After approval of the Institutional Ethics Committee and informed consent, 25 male patients in the age group of 52 to 78 years with lower urinary tract symptoms were assessed for prostate volume at different bladder volumes by USG. These results were compared with TRUS. All the tests were carried out in a single setting. Every USG and TRUS was performed by one urology resident under the guidance on one qualified radiologist with experience of over 15 years in this field. Equipment used was SIEMENS SONNOLINE ADARA with 3.5 MHz probe for USG and 7.5 MHz Endo p-2 (biplaner) probe for TRUS. Patients were first asked to empty the bladder and post void residual urine was measured along with prostate volume. Planimetric technique was used for calculating prostate volume as well as bladder volume. The following formula was used to calculate prostate as well as bladder volume: A-P Length x Cranio Caudal Length x Transverse Length x 0.52 (P/6) in cubic cm. Patients were given oral fluids and USG was repeated serially at three intervals with bladder volume of 100-200 ml, 200-300 ml and > 300 ml. Each time the prostate volume was measured. Finally uroflowmetry was carried out followed by TRUS to measure near correct prostate volume with planimetric technique. Results were recorded in tabulated forms on 'Excel spread sheet'. For each patient a division factor was calculated for all three bladder volumes by dividing USG-calculated prostate volume by TRUS-calculated prostate volume. Finally a mean division factor was calculated for each bladder volume.
| Results|| |
Measurement of prostate volume increases with increase in bladder volume. This type of linear accelerating relationship was found in all patients. In three patients residual urinary volume could not be calculated as they had perurethral catheter passed earlier for retention of urine. Their bladders were filled artificially with normal saline. Prostate volume was underestimated on USG than TRUS in nine cases (36%) at 100-200 ml bladder volume, three cases (12%) at 200-300 ml bladder volume and none (0%) at bladder volume > 300 ml. To know the exact relationship between the volumes calculated by two different modalities (TRUS and USG), a division factor was calculated. By dividing USG prostate volume by TRUS prostate volume, a division factor was calculated for each bladder volume. Finally a mean division factor was calculated for three different bladder volumes [Table - 1][Table - 2]. Calculated prostate volume by USG at minimal bladder capacity (100-200 ml) was found to be closest to the volume calculated by TRUS since it had lowest division factor.
| Discussion|| |
Digital rectal examination although a standard modality to assess prostate volume is unreliable and subjective especially if performed by different examiners., In an effort to accurately determine prostate volume, radiographic techniques have been utilized. However it has proved extremely difficult to obtain satisfactory images of the prostate gland, owing to its location deep in the pelvis behind the pubis and the inability of the prostate to retain contrast agent., ultrasonography has provided relatively accurate measurements of prostate size., However, visualization of the prostate may be obscured by the pubic bone or by small capacity bladder. It is a well established fact that TRUS provides precise images of the prostate, seminal vesicles and adjacent structures. In TRUS as the distance from the transducer to the prostate is minimal, the internal prostatic echo graphic pattern is superior to that obtained by means of USG.
Currently two techniques are employed to determine prostatic volume by TRUS: ellipsoid and plenimetric., The application of TRUS and the principle of planimetry for volume determination were originally described by Watanabe and coworkers,, and are now considered as the gold standard., The specific gravity of the prostate has been calculated to be 1.05 gm /cubic cm; hence, the weight of the prostate is essentially equal to its estimated volume. For USG the ellipsoid formula is used to calculate prostate volume.
Linear accelerating relationship between prostate volume and bladder volume observed in our study was considered for bladder volume up to 400 ml. In the present pilot project we did not investigate any patient with large bladder capacity (>400 ml). Prostate volume was underestimated on USG than TRUS in nine cases (36%) at 100-200 ml bladder volume, three cases (12%) at 200-300 ml bladder volume and none (0%) at bladder volume > 300 ml. Blanc et al have reported similar findings in their study. Yuen et al have noted that with increasing bladder volume the median lobe protrusion decreases. However, the study was restricted only to the visualization of the median lobe. In our study the entire prostate gland was considered and not just median lobe protrusion. No special effort was made to study the transitional zone as it is only visualized on TRUS and not on USG.
After analyzing our results we have suggested a division factor for USG prostate volume at different bladder volumes that can be used in our day-to-day practice. Resultant values are very close to the near correct TRUS prostate volume.
The formula is
Near correct prostate volume = prostate volume on USG for particular bladder volume ų division factor for that particular bladder volume. Working example for this is given in [Table - 3][Table - 4].
In many centers the facility for TRUS is not available. Hence the above-mentioned formula could prove very useful.
The possible explanation for the discrepancy in the estimation of the prostate volume with changing bladder volumes is as follows. Put a coin on the table and over the coin place a transparent glass beaker filled with water. The coin will appear larger when it is viewed through the medium of water. The mass of water will act as a magnifying lens. A similar mechanism may be operating during the visualization of the prostate through water medium within the bladder. Thus, larger the bladder volume, larger will be the volume of prostate as perceived by the USG probe.
Despite the above possible explanation, there is no scientific reasoning to support our hypothesis. But our observations have been supported by similar observations by Blanc et al and Yuen et al .
| Conclusion|| |
Prostate volume measurement on USG does vary with changes in bladder volume. Bladder capacity of 100-200 ml is sufficient to know near correct prostate volume on USG. One can get near correct prostate volume on USG by using a formula as suggested in this study.
| Acknowledgement|| |
Authors wish to express their gratitude to the Trustees of the Maharashtra Medical Foundation's, Ratna Memorial Hospital, 986 Senapati Bapat Road, Pune - 411004, India for the purchase of the expensive TRUS equipment and greatly subsidizing the charges for the patients.
| References|| |
|1.||Huang Foen Chung JW, de Vries SH, Raaijmakers R, Postma R, Bosch JL, van Mastrigt R. Prostate volume ultrasonography: The influence of transabdominal versus transrectal approach, device type and operator. Eur Urol 2004;46:352-6. [PUBMED] [FULLTEXT]|
|2.||Watanabe H, Kaiho H, Tanaka M, Terasawa Y. Diagnostic application of ultrasonotomography to the prostate. Invest Urol 1971;8:548-59. [PUBMED] |
|3.||Nordling J, Abrams P, Ameda K, Andersen JT, Donovan J, Griffiths D, et al . Outcome measures for research in treatment of adult males with symptoms of lower urinary tract dysfunction. Neurourol Urodyn 1998;17:263-71. |
|4.||Meyhoff HH, Hald T. Are doctors able to assess prostatic size? Scand J Urol Nephrol 1978;12:219-21. [PUBMED] |
|5.||Spigelman SS, Mcneal JE, Freiha FS, Stamey TA. Rectal examination in volume determination of carcinoma of prostate: Clinical and anatomical correlations. J Urol 1986;136:1228-30. [PUBMED] |
|6.||Prostatic Ultrasonography. BC Decker publication: Resnik; 1990. |
|7.||Boyce WH, Mckinney WM, Resnick ML, Willard JW. Ultrasonography as an aid in diagnosis and management of surgical disease of pelvis: Special emphasis on Genitourinary system. Ann Surg 1976;184:477-89. |
|8.||Wittingham TA, Bishop R. Ultrasonic estimation of the volume of enlarged prostate. Br J Radiol 1973;46:68-70. |
|9.||Henneberry M, Carter MF, Neiman HL. Estimation of prostate size by suprapubic ultrasonography. J Urol 1979;121:615-6. [PUBMED] |
|10.||Waterhouse RL, Rasnick MI. The use of transrectal prostatic ultrasonography in the evaluation of patients with prostatic carcinoma. J Urol 1989;141:233-9. |
|11.||Bruel and Kjaer: Operation Manual, Ultrasound scanner type. 1984. p. 59-65. |
|12.||Proscan Ultrasound imaging system Operator's Guide. Teknar Inc: St. Louis; 1988. p. 4-6. |
|13.||Watannabe H, Igari D, Tanahashi Y, Harada K, Saitoh M. Measurement of size and weight of prostate by means of transrectal ultrasonography. Tohoku J Exp Med 1994;114:277. |
|14.||Jones DR, Roberts EE, Griffiths GJ, Parkinson MC, Evans KT, Peeling WB. Assessment of volume measurement of the prostate using per-rectal ultrasonography. Br J Urol 1989;64:493-5. [PUBMED] |
|15.||Nordling J, Abrams P, Ameda K, Andersen JT, Donovan J, Griffiths D, et al . Outcome measures for research in treatment of adult males with symptoms of lower urinary tract dysfunction. Neurourol Urodyn 1998;17:263-71. |
|16.||Terris MK, Stammey TA. Determination of prostate volume by transrectal ultrasonography. J Urol 1991;145:984-7. |
|17.||Blanc M, Sacrini A, Avogadro A, Gattamorta M, Lazzerini F, Gattoni F, et al . Prostatic volume: Suprapubic versus transrectal ultrasonography in the control of benign prostatic hyperplasia. Radiol Med 1998;95:182-7. |
|18.||Yuen JS, Ngiap JT, Cheng CW, Foo KT. Effects of bladder volume on transabdominal ultrasound measurements of intravesical prostatic protrusion and volume. Int J Urol 2002;9:225-9. [PUBMED] [FULLTEXT]|
[Table - 1], [Table - 2], [Table - 3], [Table - 4]
|This article has been cited by|
||Assessment of in vivo calculation with ultrasonography compared to physical sections in vitro: a stereological study of prostate volumes
| ||Niyazi Acer, Mustafa Sofikerim, Tolga Ertekin, Erdoğan Unur, Mahmut «ay, Figen ÷ztŁrk |
| ||Anatomical Science International. 2010; |
|[VIEW] | [DOI]|