Indian Journal of Urology Users online:2228  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
EXPERT'S COMMENTS
Year : 2006  |  Volume : 22  |  Issue : 2  |  Page : 134
 

Expert comments


Associate Professor of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

Correspondence Address:
Anil Mandhani
Associate Professor of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.26568

Rights and Permissions

 

How to cite this article:
Mandhani A. Expert comments. Indian J Urol 2006;22:134

How to cite this URL:
Mandhani A. Expert comments. Indian J Urol [serial online] 2006 [cited 2019 May 20];22:134. Available from: http://www.indianjurol.com/text.asp?2006/22/2/134/26568


Though Dutasteride has been demonstrated to be safe and effective, no published trial in a peer reviewed literature has shown clinicallysignificant differences between Dutasteride and finasteride.[1] Clinical trials, sponsored primarily by the pharmaceutical companies who are manufacturing this drug, have shown Dutasteride to be an effective treatment of BPH compared with placebo and to likely possess efficacy similar to that of finasteride.[1] 12 month study by Glaxo smith Kline protocol AR 140001 quoted by authors also has shown that Dutasteride compared with Finasteride produced numerically, but not statistically significant greater improvement in urinary flow rate and symptoms scores after 1 year of treatment.[2] Authors in present study have reported through another pharmaceutical sponsored trial, a better result with Dutasteride than Finasteride at 6 months. They have compared the efficacy, safety and tolerability of Dutasteride (group B) with Finasteride (group A) in a fixed dose combination with a uro-selective -blocker Tamsulosin in management of symptomatic BPH, associated with LUTS. Authors have found that combination of Tamsulosin with Dutasteride results in early symptomatic relief and low post void residue than seen with Tamsulosin and Finasteride combination.

Both the groups were followed up at the end of 2nd, 4th, 8th, 12th and 24th week for clinical assessment using IPSS and other parameters.

Both the groups showed significant improvement in IPSS score, average uroflow and reduction in post void residue at 12th and 24th week but 88% of patients in Group-B experienced improvement in symptom score, urine flow and overall well being as compared to 74% in Group-A at the end of this study. Contrary to this, authors have highlighted that group B had an early improvement (10-14 days) based on subjective findings on recall basis which could be because of placebo effect. Moreover when IPSS was measured at 2, 4, 8 weeks then authors might not have found the difference in improvement in IPSS in both the groups as far as an early or late improvement in symptoms is concerned because results were analyzed at 12 and 24 weeks. Therefore, this article though provides data on better efficacy of Dutasteride in comparison to Finasteride combined with Tamsulosin, significance of difference in time to improvement in symptoms should be construed with caution.

 
   References Top

1.Dolder CR. Dutasteride: A dual 5-alpha reductase inhibitor for thetreatment of symptomatic benign Prostatic hyperplasia. Ann Pharmacother 2006;40:658-65.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Andriole GL, Kirby R. Safety and tolerability of the dual 5-reductase inhibitor Dutasteride in the treatment of Benign Prostatic Hyperplasia. Eur Urol 2003;44:82-8.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]




 

Top
Print this article  Email this article
Previous article Next article

    

 
   Search
 
   Next article
   Previous article 
   Table of Contents
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (77 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed1992    
    Printed74    
    Emailed1    
    PDF Downloaded80    
    Comments [Add]    

Recommend this journal

HEALTHWARE INDIA