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ORIGINAL ARTICLE
Year : 2001  |  Volume : 18  |  Issue : 1  |  Page : 20-21
 

The left ventricular mass index in adult polycystic kidney disease patients


Departments of Nephrology, Cardiology and Statistics, Sri Satya Sai Institute of Higher Medical Sciences & Sri Satya Sai Institute of Higher Learning, Puttaparthi, India

Correspondence Address:
V Siva Kumar
Department of Nephrology, SSSIHMS., Prasanthi Gram. Ananthapur Dt., Andhra Pradesh - 515 134
India
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Source of Support: None, Conflict of Interest: None


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Keywords: Left Ventricular Mass Index; Adult Polycystic Kidney Disease.


How to cite this article:
Prasad NG, Kumar R S, Rao R P, Kumar V S. The left ventricular mass index in adult polycystic kidney disease patients. Indian J Urol 2001;18:20-1

How to cite this URL:
Prasad NG, Kumar R S, Rao R P, Kumar V S. The left ventricular mass index in adult polycystic kidney disease patients. Indian J Urol [serial online] 2001 [cited 2020 Jul 13];18:20-1. Available from: http://www.indianjurol.com/text.asp?2001/18/1/20/37374


Adult Polycystic Kidney Disease (ADPKD) is associated with increased cardiac morbidity and mortality and one possible mechanism is left ventricular hypertrophy contributing to increased left ventricular mass index (LVMI) leading to premature cardiovascular disease and sudden death.[1], [2,[3] Increased LVMI was observed not only with hypertension but also in normotensive patients of ADPKD, suggesting that in addition to hypertension various other factors make contribution. Increase in hemodynamic load, increased reninangiotensin-aldosterone activity, sympathetic nervous activity and increased cardiac extra cellular matrix probably due to polycystin, were cited in the literature as various mechanisms for increased LVMI in ADPKD.[2],[3],[4],[5] Unlike in essential hypertension, the role of Insulin like Growth Factor-1 and Atrial Natriuritic Peptide for increased LVMI were lacking evidence in ADPKD patients.[3]

We studied 25 subjects of ADPKD with special reference to their LVMI and the results are summarized as follows. There were 17 males and 8 females, age range being 16-60 years. 14 patients had definite history of hypertension; normal serum creatinine (<1.5mg%) was noted in 10 patients. MI was assessed by M-mode echocardiography using American cardiologic society formula.[6] The mean value of LVMI of ADPKD patients was found to be high, when compared with the age matched normal Indian population mean LVMI value[7] The student's "t" test revealed significant difference between the means of ADPKD patients and normal controls (p<0.001) in both sex groups [Table]. Hence it is prudent to include the cardiac evaluation for LVMI in all ADPKD patients because of its importance in the management.

 
   References Top

1.Perrone RD. Extra renal complications of ADPKD. Kidney Int 1997: 51: 2022-2036.  Back to cited text no. 1    
2.Chapman AB, Gabow PA. Hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1997: 52: S61, S71-73.  Back to cited text no. 2    
3.Martinez-Vea A, Valero FA, Bardaji A et al. Left ventricular hypertrophy in hypertensiv e patients with autosomal dominant polycystic kidney disease: Influence of blood pressure and humoral and neuro-hormonal factors. Aln Nephrol 2000: 20: 193-200.  Back to cited text no. 3    
4.Saggar-Malik AK. Missouris CG. Gill JS et al. Left ventricular mass in normotensive subjects with autosomal dominant polycystic kidney disease. Br Med 1994: 309: 1617-1618.  Back to cited text no. 4    
5.Bardaji A. Vea Am, Gutierrez C et al. Left ventricular mass in nonnotensive young adults with autosomal dominant polycystic kidney disease. Am J Kidney Disease 1998: 36: 970-975.  Back to cited text no. 5    
6.Levin A, Singer J. Thompson CR, Ross H. Lewis M. Prevalent left ventricular hypertrophy in the predialysis population: Identifying opportunities for intervention. Am J Kidney Disease 1996: 27: 347-354.  Back to cited text no. 6    
7.Trivedi SK. Gupta OR Jain AP. Left ventricular mass in normal Indian Population. Indian Heart J 1991: 43: 155-159.  Back to cited text no. 7    



 
 
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