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ORIGINAL ARTICLE
Year : 2001  |  Volume : 17  |  Issue : 2  |  Page : 127-131

Ten years' experience with adjuvant intravesical immunotherapy in management of superficial transitional cell carcinoma of urinary bladder - a review


Department of Urology and Institute of Pathology, Safdarjang Hospital, New Delhi, India

Correspondence Address:
N K Mohanty
D-II/87, West Kidwai Nagar, New Delhi - 110 023
India
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Source of Support: None, Conflict of Interest: None


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The incidence of Transitional Cell Carcinoma (TCC) of urinary bladder is increasing worldwide. Patients with superficial TCC of urinary bladder can have a survival period of 10 years if they are detected at an early stage and appropriate intravesical adjuvant immunotherapy is instilled in time. A total number of 440 patients of superficial TCC were instilled intravesically BCG & Interferon a-2b as single drug or in combination and followed up. BCG though was most efficient, had high toxic rate while Interferon α-2b was expensive, whereas a low dose combination therapy of both showed excellent result in reducing tumor recurrences & prolonging disease pro­gression free interval. The author reviews his experience of 10 years in man­agement of these malignancies with intravesical immu­notherapy and concludes that a low dose BCG (60mg) with Interferon α-2b (5 million IU) has shown to be very effective in reducing tumor recurrences, prolonging dis­ease-progression-free interval with a very low toxicity in such patients. To achieve this a periodic maintenance dose therapy is absolutely necessary.


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