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Year : 1999  |  Volume : 15  |  Issue : 2  |  Page : 130-132

Significance and follow-up of prostatic intraepithelial neoplasia (PIN)


Dept. of Urology, Safdarjang Hospital, New Delhi, India

Correspondence Address:
N K Mohanty
Dept. of Urology, Safdarjang Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


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The importance of prostatic intraepithelial neoplasia (PIN) lies in its potential relationship with early prostatic cancer particularly high grade PIN. We reviewed our experience and recent data from the literature on ths topic. Total number of BPH patients undergoing TURP in our centre between july '94-july '98, was 450, out of which 90 patients had BPH with PIN in their histopathology report with serum PSA between 4-10 ng/ml. These patients were meticulously followed up by periodic serum PSA, needle biopsy, TRUS & DRE. On follow-up 27 patients (30 percent) out of the 90 patients progressed subsequently to carcinoma prostate and were treated accordingly. DRE. On follow-up 27 patients (30 percent) out of the 90 patients progressed subsequently to carcinoma prostate and were treated accordingly. DRE & TRUS were not much help in detection of subsequent malignancy. WE conclude that all bph with PIn particularly high grade should be followed up every six months by PSA and needle biopsy for two years and then annually, for detecting early malignancy as they are vulnerable to develop invasive cancer subsequently.


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