Indian Journal of Urology Users online:869  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 1997  |  Volume : 13  |  Issue : 1  |  Page : 75-76

Efficacy of terazosin, finasteride or both in benign prostatic hyperplasia


Department of Urology, Sri Venkateswara Institute of Medical Science, Tirupati, India

Correspondence Address:
H SGT Rao
Department of Urology, Sri Venkateswara Institute of Medical Science, Tirupati
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Patients with benign prostatic hyperplasia can be treated with alpha-1 adrenergic-antagonist drugs or with 5 alpha-reductase inhibitors. However, the effects of these two classes of pharmacological agents were not compared till the publication of the present multicenter study. This study group compared the safety and efficacy of placebo, 1Omg daily of terazosin, 5 mg daily of finasteride and the combination of both the drugs in 1229 men with benign prostatic hyperplasia. AUA symptom scores and peak urinary-flow rates were determined at base line and periodically for one year. The mean changes from baseline in the symptom scores in the placebo, finasteride, terazosin and combination groups at one year were decreases of 2.6, 3.2, 6.1 and 6.2 points respectively (p less than 0.001 for the comparisons of both terazosin and combination therapy with finasteride and with placebo). The mean alteration at one year in the peak urinary- flow rates were increases of 1.4,1.6, 2.7 and 3.2 ml per second respectively (p less than 0.001 for the comparisons of both terazosin and combination therapy with finasteride and with placebo). Finasteride had no more effect on either measure than placebo. In the placebo group, 1.6 per cent of the men discontinued the study because of adverse effects, as did 4.8 to 7.8 per cent of the men in the other three groups. The authors conclude that in men with benign prostatic hyperplasia, terazosin was effective therapy, whereas finasteride was not and the combination of terazosin and finasteride was no more effective than terazosin alone.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed769    
    Printed43    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 

HEALTHWARE INDIA