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Year : 1986  |  Volume : 3  |  Issue : 1  |  Page : 21-25

Alteration on circadian rhythmicity of serum protection in adult male patients awaiting elective urological surgery.


Department of Urology, PGIMER, Chandigarh

Correspondence Address:
T P Mohapatra
Department of Urology, PGIMER, Chandigarh

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Source of Support: None, Conflict of Interest: None


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Serum prolactin exhibits a circadian rhythm with a stable acrophase located at 0444 hr. The nadir is reached within 1-3 hours of awakening. Circadian biology of serum prolactin was investigated in 11 male adult patients in the age group of 20-30 years who were awaiting major urological surgery. Blood samples were taken at 4 hourly intervals beginning from 0000 hour. Prolactin was estimated by specific double antibody homologous radioimmunoassay. The data were analysed by cosinor rhythmometry. The acrophase was located at 0134 hour and the nadir of serum prolactin was located around 1330 hour in this group of patients who were waiting to undergo a surgical procedure. Such alteration in circadian biology could affect the periodicity of other physiological systems e.g. immunological status, susceptibility to surgical infection etc. It may be desirable to achieve euchronism by altering exogenous environmental pace makers (Zeitgebers) in the hospital wards which include noise level, light etc., and by ensuring prehospital home schedule with respect to meal patterns, social cues, slee-wake cycle, etc. during pre-operative period.


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