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Year : 1985  |  Volume : 1  |  Issue : 2  |  Page : 59-70

An overview of evolving drug therapy for disorders of micturition and its clonical implication.


Division of Urology, Hahnemann University, Philadelphia, U.S.A

Correspondence Address:
O P Khanna
Division of Urology, Hahnemann University, Philadelphia, U.S.A

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Source of Support: None, Conflict of Interest: None


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Current experimental evidence suggests that the peripheral innervation of vesicourethral smooth muscle is complex and diversified. The following peripheral nerves affect urethral and vesical functions: Cholinergic, adrenergic, purinergic, peptidergic and histaminergic neurons. Prostaglandins, 5-hydroxytryptamine (5-HT) and sex hormones may also influence urethral and vesical functions. Formerly, detrusor activity was increased or decreased using cholinergic or anticholinergic agents. Now, more complex patterns of chemical manipulation are suggested, with the aim of directly affecting multiple site such as the autonomic ganglia, peripheral neurons, end-organ receptors and even the smooth muscle itself. Based on his clinical experience and knowledge of the effects of various drugs on the vesicourethral smooth muscle, the author recommends drug therapy for micturition disorders.


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